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Cardiomyopathy, mitochondrial

MedGen UID:
759352
•Concept ID:
C3532239
•
Disease or Syndrome
Synonyms: Maternally inherited cardiomyopathy; Mitochondrial cardiomyopathy disorder
SNOMED CT: Mitochondrial cardiomyopathy (472315005)
 
OMIM®: 590055

Professional guidelines

PubMed

Differential Diagnosis of Thick Myocardium according to Histologic Features Revealed by Multiparametric Cardiac Magnetic Resonance Imaging.
Cha MJ, Kim C, Park CH, Hong YJ, Shin JM, Kim TH, Cha YJ, Park CH
Korean J Radiol 2022 Jun;23(6):581-597. Epub 2022 May 9 doi: 10.3348/kjr.2021.0815. PMID: 35555885Free PMC Article
Advances in Diagnosis and Management of Mitochondrial Cardiomyopathy.
Zhuge R, Zhou R, Ni X
Zhongguo Yi Xue Ke Xue Yuan Xue Bao 2017 Apr 20;39(2):290-295. doi: 10.3881/j.issn.1000-503X.2017.02.021. PMID: 28483032
Mitochondrial cardiomyopathy: pathophysiology, diagnosis, and management.
Meyers DE, Basha HI, Koenig MK
Tex Heart Inst J 2013;40(4):385-94. PMID: 24082366Free PMC Article

Recent clinical studies

Etiology

Pathophysiology and Treatment of Diabetic Cardiomyopathy and Heart Failure in Patients with Diabetes Mellitus.
Nakamura K, Miyoshi T, Yoshida M, Akagi S, Saito Y, Ejiri K, Matsuo N, Ichikawa K, Iwasaki K, Naito T, Namba Y, Yoshida M, Sugiyama H, Ito H
Int J Mol Sci 2022 Mar 25;23(7) doi: 10.3390/ijms23073587. PMID: 35408946Free PMC Article
Obesity cardiomyopathy: evidence, mechanisms, and therapeutic implications.
Ren J, Wu NN, Wang S, Sowers JR, Zhang Y
Physiol Rev 2021 Oct 1;101(4):1745-1807. Epub 2021 May 5 doi: 10.1152/physrev.00030.2020. PMID: 33949876Free PMC Article
Diabetic Cardiomyopathy.
Dillmann WH
Circ Res 2019 Apr 12;124(8):1160-1162. doi: 10.1161/CIRCRESAHA.118.314665. PMID: 30973809Free PMC Article
Heart Failure in Type 2 Diabetes Mellitus.
Kenny HC, Abel ED
Circ Res 2019 Jan 4;124(1):121-141. doi: 10.1161/CIRCRESAHA.118.311371. PMID: 30605420Free PMC Article
Mitochondrial cardiomyopathy: pathophysiology, diagnosis, and management.
Meyers DE, Basha HI, Koenig MK
Tex Heart Inst J 2013;40(4):385-94. PMID: 24082366Free PMC Article

Diagnosis

Altered Cardiac Energetics and Mitochondrial Dysfunction in Hypertrophic Cardiomyopathy.
Ranjbarvaziri S, Kooiker KB, Ellenberger M, Fajardo G, Zhao M, Vander Roest AS, Woldeyes RA, Koyano TT, Fong R, Ma N, Tian L, Traber GM, Chan F, Perrino J, Reddy S, Chiu W, Wu JC, Woo JY, Ruppel KM, Spudich JA, Snyder MP, Contrepois K, Bernstein D
Circulation 2021 Nov 23;144(21):1714-1731. Epub 2021 Oct 21 doi: 10.1161/CIRCULATIONAHA.121.053575. PMID: 34672721Free PMC Article
HIF‑1α in myocardial ischemia‑reperfusion injury (Review).
Zheng J, Chen P, Zhong J, Cheng Y, Chen H, He Y, Chen C
Mol Med Rep 2021 May;23(5) Epub 2021 Mar 24 doi: 10.3892/mmr.2021.11991. PMID: 33760122Free PMC Article
Drug-induced mitochondrial dysfunction and cardiotoxicity.
Varga ZV, Ferdinandy P, Liaudet L, Pacher P
Am J Physiol Heart Circ Physiol 2015 Nov;309(9):H1453-67. Epub 2015 Sep 18 doi: 10.1152/ajpheart.00554.2015. PMID: 26386112Free PMC Article
Left ventricular non-compaction cardiomyopathy.
Towbin JA, Lorts A, Jefferies JL
Lancet 2015 Aug 22;386(9995):813-25. Epub 2015 Apr 9 doi: 10.1016/S0140-6736(14)61282-4. PMID: 25865865
Mitochondrial cardiomyopathy: pathophysiology, diagnosis, and management.
Meyers DE, Basha HI, Koenig MK
Tex Heart Inst J 2013;40(4):385-94. PMID: 24082366Free PMC Article

Therapy

USP28 Serves as a Key Suppressor of Mitochondrial Morphofunctional Defects and Cardiac Dysfunction in the Diabetic Heart.
Xie SY, Liu SQ, Zhang T, Shi WK, Xing Y, Fang WX, Zhang M, Chen MY, Xu SC, Fan MQ, Li LL, Zhang H, Zhao N, Zeng ZX, Chen S, Zeng XF, Deng W, Tang QZ
Circulation 2024 Feb 27;149(9):684-706. Epub 2023 Nov 23 doi: 10.1161/CIRCULATIONAHA.123.065603. PMID: 37994595
Mitochondrial Determinants of Doxorubicin-Induced Cardiomyopathy.
Wallace KB, Sardão VA, Oliveira PJ
Circ Res 2020 Mar 27;126(7):926-941. Epub 2020 Mar 26 doi: 10.1161/CIRCRESAHA.119.314681. PMID: 32213135Free PMC Article
Diabetic Cardiomyopathy.
Dillmann WH
Circ Res 2019 Apr 12;124(8):1160-1162. doi: 10.1161/CIRCRESAHA.118.314665. PMID: 30973809Free PMC Article
Heart Failure in Type 2 Diabetes Mellitus.
Kenny HC, Abel ED
Circ Res 2019 Jan 4;124(1):121-141. doi: 10.1161/CIRCRESAHA.118.311371. PMID: 30605420Free PMC Article
Drug-induced mitochondrial dysfunction and cardiotoxicity.
Varga ZV, Ferdinandy P, Liaudet L, Pacher P
Am J Physiol Heart Circ Physiol 2015 Nov;309(9):H1453-67. Epub 2015 Sep 18 doi: 10.1152/ajpheart.00554.2015. PMID: 26386112Free PMC Article

Prognosis

Septic Cardiomyopathy: From Basics to Management Choices.
Ravikumar N, Sayed MA, Poonsuph CJ, Sehgal R, Shirke MM, Harky A
Curr Probl Cardiol 2021 Apr;46(4):100767. Epub 2020 Dec 11 doi: 10.1016/j.cpcardiol.2020.100767. PMID: 33388489
Basic Mechanisms of Diabetic Heart Disease.
Ritchie RH, Abel ED
Circ Res 2020 May 22;126(11):1501-1525. Epub 2020 May 21 doi: 10.1161/CIRCRESAHA.120.315913. PMID: 32437308Free PMC Article
Mitochondrial ROS in myocardial ischemia reperfusion and remodeling.
Bugger H, Pfeil K
Biochim Biophys Acta Mol Basis Dis 2020 Jul 1;1866(7):165768. Epub 2020 Mar 12 doi: 10.1016/j.bbadis.2020.165768. PMID: 32173461
Heart Failure in Type 2 Diabetes Mellitus.
Kenny HC, Abel ED
Circ Res 2019 Jan 4;124(1):121-141. doi: 10.1161/CIRCRESAHA.118.311371. PMID: 30605420Free PMC Article
Mitochondrial cardiomyopathy: pathophysiology, diagnosis, and management.
Meyers DE, Basha HI, Koenig MK
Tex Heart Inst J 2013;40(4):385-94. PMID: 24082366Free PMC Article

Clinical prediction guides

Cardiac lipid metabolism, mitochondrial function, and heart failure.
Da Dalt L, Cabodevilla AG, Goldberg IJ, Norata GD
Cardiovasc Res 2023 Aug 19;119(10):1905-1914. doi: 10.1093/cvr/cvad100. PMID: 37392421Free PMC Article
Proteasomal Degradation of TRAF2 Mediates Mitochondrial Dysfunction in Doxorubicin-Cardiomyopathy.
Dhingra R, Rabinovich-Nikitin I, Rothman S, Guberman M, Gang H, Margulets V, Jassal DS, Alagarsamy KN, Dhingra S, Valenzuela Ripoll C, Billia F, Diwan A, Javaheri A, Kirshenbaum LA
Circulation 2022 Sep 20;146(12):934-954. Epub 2022 Aug 19 doi: 10.1161/CIRCULATIONAHA.121.058411. PMID: 35983756Free PMC Article
Pathophysiology and Treatment of Diabetic Cardiomyopathy and Heart Failure in Patients with Diabetes Mellitus.
Nakamura K, Miyoshi T, Yoshida M, Akagi S, Saito Y, Ejiri K, Matsuo N, Ichikawa K, Iwasaki K, Naito T, Namba Y, Yoshida M, Sugiyama H, Ito H
Int J Mol Sci 2022 Mar 25;23(7) doi: 10.3390/ijms23073587. PMID: 35408946Free PMC Article
Insulin resistance and hyperinsulinaemia in diabetic cardiomyopathy.
Jia G, DeMarco VG, Sowers JR
Nat Rev Endocrinol 2016 Mar;12(3):144-53. Epub 2015 Dec 18 doi: 10.1038/nrendo.2015.216. PMID: 26678809Free PMC Article
Mitochondrial cardiomyopathy: pathophysiology, diagnosis, and management.
Meyers DE, Basha HI, Koenig MK
Tex Heart Inst J 2013;40(4):385-94. PMID: 24082366Free PMC Article

Recent systematic reviews

The cellular mechanism of antipsychotic-induced myocarditis: A systematic review.
Vaziri N, Marques D, Greenway SC, Bousman CA
Schizophr Res 2023 Nov;261:206-215. Epub 2023 Oct 3 doi: 10.1016/j.schres.2023.09.039. PMID: 37797362
Electrolyte Disorders in Mitochondrial Cytopathies: A Systematic Review.
Viering DHHM, Vermeltfoort L, Bindels RJM, Deinum J, de Baaij JHF
J Am Soc Nephrol 2023 Nov 1;34(11):1875-1888. Epub 2023 Sep 6 doi: 10.1681/ASN.0000000000000224. PMID: 37678265Free PMC Article
Crosstalk between microRNA and Oxidative Stress in Heart Failure: A Systematic Review.
Klimczak-Tomaniak D, Haponiuk-Skwarlińska J, Kuch M, Pączek L
Int J Mol Sci 2022 Nov 30;23(23) doi: 10.3390/ijms232315013. PMID: 36499336Free PMC Article
Ketogenic diet for mitochondrial disease: a systematic review on efficacy and safety.
Zweers H, van Wegberg AMJ, Janssen MCH, Wortmann SB
Orphanet J Rare Dis 2021 Jul 3;16(1):295. doi: 10.1186/s13023-021-01927-w. PMID: 34217336Free PMC Article
Systematic Review of Genotype-Phenotype Correlations in Noncompaction Cardiomyopathy.
van Waning JI, Moesker J, Heijsman D, Boersma E, Majoor-Krakauer D
J Am Heart Assoc 2019 Dec 3;8(23):e012993. Epub 2019 Nov 27 doi: 10.1161/JAHA.119.012993. PMID: 31771441Free PMC Article

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