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Atrial fibrillation, familial, 16(ATFB16)

MedGen UID:
862136
Concept ID:
C4013699
Finding
Synonym: ATFB16
 
Monarch Initiative: MONDO:0800349
OMIM®: 608214; 613120

Definition

Familial atrial fibrillation is an inherited abnormality of the heart's normal rhythm. Atrial fibrillation is characterized by episodes of uncoordinated electrical activity (fibrillation) in the heart's upper chambers (the atria), which cause a fast and irregular heartbeat. If untreated, this abnormal heart rhythm (arrhythmia) can lead to dizziness, chest pain, a sensation of fluttering or pounding in the chest (palpitations), shortness of breath, or fainting (syncope). Atrial fibrillation also increases the risk of stroke and sudden death. Complications of atrial fibrillation can occur at any age, although some people with this heart condition never experience any health problems associated with the disorder. [from MedlinePlus Genetics]

Professional guidelines

PubMed

Wiersinga WM, Poppe KG, Effraimidis G
Lancet Diabetes Endocrinol 2023 Apr;11(4):282-298. Epub 2023 Feb 24 doi: 10.1016/S2213-8587(23)00005-0. PMID: 36848916
Mendelson SJ, Prabhakaran S
JAMA 2021 Mar 16;325(11):1088-1098. doi: 10.1001/jama.2020.26867. PMID: 33724327
Dobrev D, Aguilar M, Heijman J, Guichard JB, Nattel S
Nat Rev Cardiol 2019 Jul;16(7):417-436. doi: 10.1038/s41569-019-0166-5. PMID: 30792496

Curated

UK NICE Guideline NG196, Atrial fibrillation: diagnosis and management, 2021

Recent clinical studies

Etiology

Naser JA, Lee E, Scott CG, Kennedy AM, Pellikka PA, Lin G, Pislaru SV, Borlaug BA
Eur Heart J 2023 Dec 21;44(48):5049-5060. doi: 10.1093/eurheartj/ehad592. PMID: 37639219
Noseworthy PA, Attia ZI, Behnken EM, Giblon RE, Bews KA, Liu S, Gosse TA, Linn ZD, Deng Y, Yin J, Gersh BJ, Graff-Radford J, Rabinstein AA, Siontis KC, Friedman PA, Yao X
Lancet 2022 Oct 8;400(10359):1206-1212. Epub 2022 Sep 27 doi: 10.1016/S0140-6736(22)01637-3. PMID: 36179758
Chung MK, Eckhardt LL, Chen LY, Ahmed HM, Gopinathannair R, Joglar JA, Noseworthy PA, Pack QR, Sanders P, Trulock KM; American Heart Association Electrocardiography and Arrhythmias Committee and Exercise, Cardiac Rehabilitation, and Secondary Prevention Committee of the Council on Clinical Cardiology; Council on Arteriosclerosis, Thrombosis and Vascular Biology; Council on Cardiovascular and Stroke Nursing; and Council on Lifestyle and Cardiometabolic Health
Circulation 2020 Apr 21;141(16):e750-e772. Epub 2020 Mar 9 doi: 10.1161/CIR.0000000000000748. PMID: 32148086
Writing Group Members, January CT, Wann LS, Calkins H, Chen LY, Cigarroa JE, Cleveland JC Jr, Ellinor PT, Ezekowitz MD, Field ME, Furie KL, Heidenreich PA, Murray KT, Shea JB, Tracy CM, Yancy CW
Heart Rhythm 2019 Aug;16(8):e66-e93. Epub 2019 Jan 28 doi: 10.1016/j.hrthm.2019.01.024. PMID: 30703530
Reddy V, Taha W, Kundumadam S, Khan M
Indian Heart J 2017 Jul-Aug;69(4):545-550. Epub 2017 Jul 5 doi: 10.1016/j.ihj.2017.07.004. PMID: 28822529Free PMC Article

Diagnosis

Naser JA, Lee E, Scott CG, Kennedy AM, Pellikka PA, Lin G, Pislaru SV, Borlaug BA
Eur Heart J 2023 Dec 21;44(48):5049-5060. doi: 10.1093/eurheartj/ehad592. PMID: 37639219
Noseworthy PA, Attia ZI, Behnken EM, Giblon RE, Bews KA, Liu S, Gosse TA, Linn ZD, Deng Y, Yin J, Gersh BJ, Graff-Radford J, Rabinstein AA, Siontis KC, Friedman PA, Yao X
Lancet 2022 Oct 8;400(10359):1206-1212. Epub 2022 Sep 27 doi: 10.1016/S0140-6736(22)01637-3. PMID: 36179758
Reddy V, Taha W, Kundumadam S, Khan M
Indian Heart J 2017 Jul-Aug;69(4):545-550. Epub 2017 Jul 5 doi: 10.1016/j.ihj.2017.07.004. PMID: 28822529Free PMC Article
Dalen JE, Alpert JS
Am J Med 2017 Mar;130(3):264-267. Epub 2016 Oct 15 doi: 10.1016/j.amjmed.2016.09.027. PMID: 27756556
Bontempo LJ, Goralnick E
Emerg Med Clin North Am 2011 Nov;29(4):747-58, vi. Epub 2011 Sep 29 doi: 10.1016/j.emc.2011.08.008. PMID: 22040705

Therapy

Chieng D, Sugumar H, Segan L, Tan C, Vizi D, Nanayakkara S, Al-Kaisey A, Hawson J, Prabhu S, Voskoboinik A, Finch S, Morton JB, Lee G, Mariani J, La Gerche A, Taylor AJ, Howden E, Kistler PM, Kalman JM, Kaye DM, Ling LH
JACC Heart Fail 2023 Jun;11(6):646-658. Epub 2023 Mar 1 doi: 10.1016/j.jchf.2023.01.008. PMID: 36868916
Noseworthy PA, Attia ZI, Behnken EM, Giblon RE, Bews KA, Liu S, Gosse TA, Linn ZD, Deng Y, Yin J, Gersh BJ, Graff-Radford J, Rabinstein AA, Siontis KC, Friedman PA, Yao X
Lancet 2022 Oct 8;400(10359):1206-1212. Epub 2022 Sep 27 doi: 10.1016/S0140-6736(22)01637-3. PMID: 36179758
Lan Q, Wu F, Han B, Ma L, Han J, Yao Y
Am J Emerg Med 2022 Jan;51:248-256. Epub 2021 Nov 6 doi: 10.1016/j.ajem.2021.08.082. PMID: 34781150
Kuck KH, Merkely B, Zahn R, Arentz T, Seidl K, Schlüter M, Tilz RR, Piorkowski C, Gellér L, Kleemann T, Hindricks G
Circ Arrhythm Electrophysiol 2019 Dec;12(12):e007731. Epub 2019 Nov 25 doi: 10.1161/CIRCEP.119.007731. PMID: 31760819
Prabhu S, Taylor AJ, Costello BT, Kaye DM, McLellan AJA, Voskoboinik A, Sugumar H, Lockwood SM, Stokes MB, Pathik B, Nalliah CJ, Wong GR, Azzopardi SM, Gutman SJ, Lee G, Layland J, Mariani JA, Ling LH, Kalman JM, Kistler PM
J Am Coll Cardiol 2017 Oct 17;70(16):1949-1961. Epub 2017 Aug 27 doi: 10.1016/j.jacc.2017.08.041. PMID: 28855115

Prognosis

Zhang W, Liang J, Li C, Gao D, Ma Q, Pan Y, Wang Y, Xie W, Zheng F
JAMA Netw Open 2023 Nov 1;6(11):e2342744. doi: 10.1001/jamanetworkopen.2023.42744. PMID: 37938842Free PMC Article
Naser JA, Lee E, Scott CG, Kennedy AM, Pellikka PA, Lin G, Pislaru SV, Borlaug BA
Eur Heart J 2023 Dec 21;44(48):5049-5060. doi: 10.1093/eurheartj/ehad592. PMID: 37639219
Guha A, Fradley MG, Dent SF, Weintraub NL, Lustberg MB, Alonso A, Addison D
Eur Heart J 2022 Jan 31;43(4):300-312. doi: 10.1093/eurheartj/ehab745. PMID: 34791123Free PMC Article
Lippi G, Sanchis-Gomar F, Cervellin G
Int J Stroke 2021 Feb;16(2):217-221. Epub 2020 Jan 19 doi: 10.1177/1747493019897870. PMID: 31955707
Ko D, Rahman F, Schnabel RB, Yin X, Benjamin EJ, Christophersen IE
Nat Rev Cardiol 2016 Jun;13(6):321-32. Epub 2016 Apr 7 doi: 10.1038/nrcardio.2016.45. PMID: 27053455Free PMC Article

Clinical prediction guides

Toledo E, Wittenbecher C, Razquin C, Ruiz-Canela M, Clish CB, Liang L, Alonso A, Hernández-Alonso P, Becerra-Tomás N, Arós-Borau F, Corella D, Ros E, Estruch R, García-Rodríguez A, Fitó M, Lapetra J, Fiol M, Alonso-Gomez ÁM, Serra-Majem L, Deik A, Salas-Salvadó J, Hu FB, Martínez-González MA
J Physiol Biochem 2023 May;79(2):355-364. Epub 2023 Apr 1 doi: 10.1007/s13105-023-00958-0. PMID: 37004634Free PMC Article
Nagueh SF, Khan SU
JACC Cardiovasc Imaging 2023 May;16(5):691-707. Epub 2023 Jan 11 doi: 10.1016/j.jcmg.2022.10.011. PMID: 36752445
Raposeiras Roubín S, Abu Assi E, Muñoz Pousa I, Domínguez Erquicia P, Melendo Viu M, Gonzalez Bermudez I, Íñiguez Romo A
Am J Cardiol 2022 Mar 15;167:139-146. Epub 2022 Jan 10 doi: 10.1016/j.amjcard.2021.11.053. PMID: 35027138
Louka AM, Tsagkaris C, Stoica A
Rom J Intern Med 2021 Dec 1;59(4):321-327. Epub 2021 Nov 20 doi: 10.2478/rjim-2021-0018. PMID: 33951355
Ren J, Yang Y, Zhu J, Wu S, Wang J, Zhang H, Shao X, Lyu S
Clin Cardiol 2021 Feb;44(2):168-175. Epub 2020 Dec 12 doi: 10.1002/clc.23519. PMID: 33314221Free PMC Article

Recent systematic reviews

Poon WH, Ling RR, Yang IX, Luo H, Kofidis T, MacLaren G, Tham C, Teoh KLK, Ramanathan K
Anaesthesia 2023 Mar;78(3):371-380. Epub 2022 Dec 19 doi: 10.1111/anae.15947. PMID: 36535747
Lan Q, Wu F, Han B, Ma L, Han J, Yao Y
Am J Emerg Med 2022 Jan;51:248-256. Epub 2021 Nov 6 doi: 10.1016/j.ajem.2021.08.082. PMID: 34781150
Ramesh T, Lee PYK, Mitta M, Allencherril J
J Cardiol 2021 Nov;78(5):375-381. Epub 2021 Jun 20 doi: 10.1016/j.jjcc.2021.06.001. PMID: 34162502
Al-Arkee S, Mason J, Lane DA, Fabritz L, Chua W, Haque MS, Jalal Z
J Med Internet Res 2021 May 25;23(5):e24190. doi: 10.2196/24190. PMID: 34032583Free PMC Article
Proietti M, Romanazzi I, Romiti GF, Farcomeni A, Lip GYH
Stroke 2018 Jan;49(1):98-106. Epub 2017 Nov 22 doi: 10.1161/STROKEAHA.117.018395. PMID: 29167388

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Curated

    • NICE, 2021
      UK NICE Guideline NG196, Atrial fibrillation: diagnosis and management, 2021

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