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Diabetes mellitus, noninsulin-dependent, 5(T2D5)

MedGen UID:
863620
•Concept ID:
C4015183
•
Disease or Syndrome
Synonyms: T2D5; TYPE 2 DIABETES 5
 
Gene (location): TBC1D4 (13q22.2)
 
Monarch Initiative: MONDO:0014488
OMIM®: 616087

Definition

Any type 2 diabetes mellitus in which the cause of the disease is a mutation in the TBC1D4 gene. [from MONDO]

Professional guidelines

PubMed

Rural treatment of COVID-19 patients with pirfenidone, nitazoxanide and colchicine. Case series.
Iturbe Esquivel B, Meneses Calderón J, Concepción Carrillo LE, Mendieta Zeron H
Monaldi Arch Chest Dis 2022 Jun 8;93(1) doi: 10.4081/monaldi.2022.2143. PMID: 35678532
Management of type 2 diabetes mellitus in children and adolescents.
Springer SC, Silverstein J, Copeland K, Moore KR, Prazar GE, Raymer T, Shiffman RN, Thaker VV, Anderson M, Spann SJ, Flinn SK; American Academy of Pediatrics
Pediatrics 2013 Feb;131(2):e648-64. Epub 2013 Jan 28 doi: 10.1542/peds.2012-3496. PMID: 23359584
The effect of dietary treatment on lipid peroxidation and antioxidant status in newly diagnosed noninsulin dependent diabetes.
Armstrong AM, Chestnutt JE, Gormley MJ, Young IS
Free Radic Biol Med 1996;21(5):719-26. doi: 10.1016/0891-5849(96)00169-4. PMID: 8891676

Recent clinical studies

Etiology

10-Year Cardiovascular Risk in Patients With Newly Diagnosed Type 2 Diabetes Mellitus.
Gyldenkerne C, Mortensen MB, Kahlert J, Thrane PG, Warnakula Olesen KK, Sørensen HT, Thomsen RW, Maeng M
J Am Coll Cardiol 2023 Oct 17;82(16):1583-1594. doi: 10.1016/j.jacc.2023.08.015. PMID: 37821168
Comparing the Efficacies of Telemedicine and Standard Prenatal Care on Blood Glucose Control in Women With Gestational Diabetes Mellitus: Randomized Controlled Trial.
Tian Y, Zhang S, Huang F, Ma L
JMIR Mhealth Uhealth 2021 May 25;9(5):e22881. doi: 10.2196/22881. PMID: 33783365Free PMC Article
Management of type 2 diabetes mellitus in children and adolescents.
Springer SC, Silverstein J, Copeland K, Moore KR, Prazar GE, Raymer T, Shiffman RN, Thaker VV, Anderson M, Spann SJ, Flinn SK; American Academy of Pediatrics
Pediatrics 2013 Feb;131(2):e648-64. Epub 2013 Jan 28 doi: 10.1542/peds.2012-3496. PMID: 23359584
Environmental toxins, a potential risk factor for diabetes among Canadian Aboriginals.
Sharp D
Int J Circumpolar Health 2009 Sep;68(4):316-26. doi: 10.3402/ijch.v68i4.17372. PMID: 19917184
Economic costs of obesity.
Colditz GA
Am J Clin Nutr 1992 Feb;55(2 Suppl):503S-507S. doi: 10.1093/ajcn/55.2.503s. PMID: 1733119

Diagnosis

10-Year Cardiovascular Risk in Patients With Newly Diagnosed Type 2 Diabetes Mellitus.
Gyldenkerne C, Mortensen MB, Kahlert J, Thrane PG, Warnakula Olesen KK, Sørensen HT, Thomsen RW, Maeng M
J Am Coll Cardiol 2023 Oct 17;82(16):1583-1594. doi: 10.1016/j.jacc.2023.08.015. PMID: 37821168
Comparing the Efficacies of Telemedicine and Standard Prenatal Care on Blood Glucose Control in Women With Gestational Diabetes Mellitus: Randomized Controlled Trial.
Tian Y, Zhang S, Huang F, Ma L
JMIR Mhealth Uhealth 2021 May 25;9(5):e22881. doi: 10.2196/22881. PMID: 33783365Free PMC Article
Management of type 2 diabetes mellitus in children and adolescents.
Springer SC, Silverstein J, Copeland K, Moore KR, Prazar GE, Raymer T, Shiffman RN, Thaker VV, Anderson M, Spann SJ, Flinn SK; American Academy of Pediatrics
Pediatrics 2013 Feb;131(2):e648-64. Epub 2013 Jan 28 doi: 10.1542/peds.2012-3496. PMID: 23359584
Mutations in the genes encoding the transcription factors hepatocyte nuclear factor 1 alpha and 4 alpha in maturity-onset diabetes of the young and hyperinsulinemic hypoglycemia.
Colclough K, Bellanne-Chantelot C, Saint-Martin C, Flanagan SE, Ellard S
Hum Mutat 2013 May;34(5):669-85. Epub 2013 Apr 2 doi: 10.1002/humu.22279. PMID: 23348805
Serum insulin, IGF-I,IGF-II and growth hormone, and left ventricular mass in noninsulin-dependent mellitus.
Rabkin SW, Dawson KG, Bhaumick B, O'Brein E, Kendler DL
Can J Cardiol 1996 Mar;12(3):264-70. PMID: 8624976

Therapy

Comparing the Efficacies of Telemedicine and Standard Prenatal Care on Blood Glucose Control in Women With Gestational Diabetes Mellitus: Randomized Controlled Trial.
Tian Y, Zhang S, Huang F, Ma L
JMIR Mhealth Uhealth 2021 May 25;9(5):e22881. doi: 10.2196/22881. PMID: 33783365Free PMC Article
Kaposi sarcoma in Southern Finland (2006-2018).
Kluger N, Blomqvist C, Kivelä P
Int J Dermatol 2019 Nov;58(11):1258-1263. Epub 2019 Jun 20 doi: 10.1111/ijd.14563. PMID: 31222805
Management of type 2 diabetes mellitus in children and adolescents.
Springer SC, Silverstein J, Copeland K, Moore KR, Prazar GE, Raymer T, Shiffman RN, Thaker VV, Anderson M, Spann SJ, Flinn SK; American Academy of Pediatrics
Pediatrics 2013 Feb;131(2):e648-64. Epub 2013 Jan 28 doi: 10.1542/peds.2012-3496. PMID: 23359584
Environmental toxins, a potential risk factor for diabetes among Canadian Aboriginals.
Sharp D
Int J Circumpolar Health 2009 Sep;68(4):316-26. doi: 10.3402/ijch.v68i4.17372. PMID: 19917184
Benfluorex in obese noninsulin dependent diabetes mellitus patients poorly controlled by insulin: a double blind study versus placebo.
Pontiroli AE, Pacchioni M, Piatti PM, Cassisa C, Camisasca R, Pozza G
J Clin Endocrinol Metab 1996 Oct;81(10):3727-32. doi: 10.1210/jcem.81.10.8855830. PMID: 8855830

Prognosis

Immunological and clinical characteristics of latent autoimmune diabetes in the elderly.
Yohena S, Penas-Steinhardt A, Muller C, Faccinetti NI, Cerrone GE, Lovecchio S, Ridner E, Valdez S, Frechtel G
Diabetes Metab Res Rev 2019 Jul;35(5):e3137. Epub 2019 Mar 1 doi: 10.1002/dmrr.3137. PMID: 30743316
Impact of Insulin Dependence on Perioperative Outcomes Following Anterior Cervical Discectomy and Fusion.
Phan K, Kim JS, Lee N, Kothari P, Cho SK
Spine (Phila Pa 1976) 2017 Apr 1;42(7):456-464. doi: 10.1097/BRS.0000000000001829. PMID: 27488292
Insulin-dependent diabetes and serious trauma.
Liou DZ, Singer MB, Barmparas G, Harada MY, Mirocha J, Bukur M, Salim A, Ley EJ
Eur J Trauma Emerg Surg 2016 Aug;42(4):491-496. Epub 2015 Aug 8 doi: 10.1007/s00068-015-0561-5. PMID: 26253885
Renal protection in diabetes--an emerging role for calcium antagonists.
Parving HH, Tarnow L, Rossing P
Cardiology 1997;88 Suppl 3:56-62. doi: 10.1159/000177509. PMID: 9397296
Fasting hypertriglyceridemia in noninsulin-dependent diabetes mellitus is an important predictor of postprandial lipid and lipoprotein abnormalities.
Lewis GF, O'Meara NM, Soltys PA, Blackman JD, Iverius PH, Pugh WL, Getz GS, Polonsky KS
J Clin Endocrinol Metab 1991 Apr;72(4):934-44. doi: 10.1210/jcem-72-4-934. PMID: 2005221

Clinical prediction guides

Clinical outcomes of percutaneous coronary intervention in chronic total occlusion in patients with type 2 diabetes mellitus.
Costa H, Espírito-Santo M, Bispo J, Guedes J, Mimoso J, Palmeiro H, Baptista Gonçalves R, Vinhas H
Rev Port Cardiol 2024 Apr;43(4):167-174. Epub 2023 Dec 21 doi: 10.1016/j.repc.2023.07.009. PMID: 38141872
Serum insulin, IGF-I,IGF-II and growth hormone, and left ventricular mass in noninsulin-dependent mellitus.
Rabkin SW, Dawson KG, Bhaumick B, O'Brein E, Kendler DL
Can J Cardiol 1996 Mar;12(3):264-70. PMID: 8624976
Abdominal obesity as important component of insulin-resistance syndrome.
Després JP
Nutrition 1993 Sep-Oct;9(5):452-9. PMID: 8286886
Fasting hypertriglyceridemia in noninsulin-dependent diabetes mellitus is an important predictor of postprandial lipid and lipoprotein abnormalities.
Lewis GF, O'Meara NM, Soltys PA, Blackman JD, Iverius PH, Pugh WL, Getz GS, Polonsky KS
J Clin Endocrinol Metab 1991 Apr;72(4):934-44. doi: 10.1210/jcem-72-4-934. PMID: 2005221
Glipizide: an overview.
Shuman CR
Am J Med 1983 Nov 30;75(5B):55-9. doi: 10.1016/0002-9343(83)90254-1. PMID: 6369968

Recent systematic reviews

Diabetes mellitus and adverse outcomes after carotid endarterectomy: A systematic review and meta-analysis.
Li F, Zhang R, Di X, Niu S, Rong Z, Liu C, Ni L
Chin Med J (Engl) 2023 Jun 20;136(12):1401-1409. Epub 2023 May 22 doi: 10.1097/CM9.0000000000002730. PMID: 37334731Free PMC Article
Sleeve gastrectomy versus Roux-en-Y Gastric Bypass for remission of type 2 diabetes mellitus at 1, 3 and 5 years: a systematic review and meta-analysis.
Fatima K, Farooqui SK, Ajaz I, Ali ST, Hashmi N, Nadeem S, Ghazi SA, Kaleem SH, Bozdar FS, Noorani M
Minerva Gastroenterol (Torino) 2022 Dec;68(4):450-458. Epub 2022 Apr 7 doi: 10.23736/S2724-5985.22.03117-5. PMID: 35388663
Management of type 2 diabetes mellitus in children and adolescents.
Springer SC, Silverstein J, Copeland K, Moore KR, Prazar GE, Raymer T, Shiffman RN, Thaker VV, Anderson M, Spann SJ, Flinn SK; American Academy of Pediatrics
Pediatrics 2013 Feb;131(2):e648-64. Epub 2013 Jan 28 doi: 10.1542/peds.2012-3496. PMID: 23359584
Publication of recruitment methods in focus group research of minority populations with chronic disease: a systematic review.
Ndumele CD, Ableman G, Russell BE, Gurrola E, Hicks LS
J Health Care Poor Underserved 2011 Feb;22(1):5-23. doi: 10.1353/hpu.2011.0031. PMID: 21317503

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