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Thyroid cancer, nonmedullary, 5(NMTC5)

MedGen UID:
895900
Concept ID:
C4225292
Neoplastic Process
Synonym: NMTC5
 
Gene (location): HABP2 (10q25.3)
 
Monarch Initiative: MONDO:0014682
OMIM®: 616535

Definition

Nonmedullary thyroid cancer (NMTC) comprises cancer of follicular cell origin and accounts for more than 95% of all cases of thyroid cancer. Familial NMTC accounts for 3 to 9% of all cases of thyroid cancer and has an autosomal dominant mode of inheritance. Most cases of familial NMTC are papillary thyroid cancer (PTC), which is the most common type of thyroid cancer (summary by Gara et al., 2015). For a general phenotypic description and a discussion of genetic heterogeneity of NMTC, see NMTC1 (188550). [from OMIM]

Clinical features

From HPO
Familial nonmedullary thyroid carcinoma
MedGen UID:
502247
Concept ID:
C3501843
Neoplastic Process
A rare non-syndromic form of thyroid cancer characterized by occurrence of thyroid carcinoma (TC) as the primary feature in a familial setting.

Professional guidelines

PubMed

Kobaly K, Kim CS, Mandel SJ
Annu Rev Med 2022 Jan 27;73:517-528. Epub 2021 Aug 20 doi: 10.1146/annurev-med-042220-015032. PMID: 34416120
Grani G, Sponziello M, Pecce V, Ramundo V, Durante C
J Clin Endocrinol Metab 2020 Sep 1;105(9):2869-83. doi: 10.1210/clinem/dgaa322. PMID: 32491169Free PMC Article
Francis GL, Waguespack SG, Bauer AJ, Angelos P, Benvenga S, Cerutti JM, Dinauer CA, Hamilton J, Hay ID, Luster M, Parisi MT, Rachmiel M, Thompson GB, Yamashita S; American Thyroid Association Guidelines Task Force
Thyroid 2015 Jul;25(7):716-59. doi: 10.1089/thy.2014.0460. PMID: 25900731Free PMC Article

Curated

UK NICE Guideline NG230, Thyroid cancer: assessment and management

Recent clinical studies

Etiology

Lee JS, Lee JS, Yun HJ, Kim SM, Chang H, Lee YS, Chang HS, Park CS
J Clin Endocrinol Metab 2023 May 17;108(6):1370-1375. doi: 10.1210/clinem/dgac739. PMID: 36546348Free PMC Article
Hei H, Zhou B, Gong W, Zheng C, Fang J, Qin J
Surg Today 2023 Apr;53(4):507-512. Epub 2022 Oct 6 doi: 10.1007/s00595-022-02595-4. PMID: 36202940
Dong W, Horiuchi K, Noguchi E, Okamoto T
Head Neck 2022 Jul;44(7):1623-1630. Epub 2022 Apr 22 doi: 10.1002/hed.27067. PMID: 35452140
Propst EJ, Wasserman JD, Gorodensky J, Ngan BY, Wolter NE
Laryngoscope 2021 Mar;131(3):E1002-E1009. Epub 2020 Aug 1 doi: 10.1002/lary.28937. PMID: 32738066
Miao H, Liu X, Li J, Zhang L, Zhao Y, Liu S, Ni S, Wu Y
Chemosphere 2020 Feb;241:125093. Epub 2019 Oct 11 doi: 10.1016/j.chemosphere.2019.125093. PMID: 31629241

Diagnosis

Dietz LK, Reece MKJ, Kadakia S
Am J Otolaryngol 2024 Sep-Oct;45(5):104438. Epub 2024 Jul 24 doi: 10.1016/j.amjoto.2024.104438. PMID: 39094302
Kalantri SH, D'Cruze L, Barathi G, Singh BK
J Cancer Res Ther 2023 Jul-Sep;19(5):1471-1473. doi: 10.4103/jcrt.jcrt_1028_21. PMID: 37787334
Kant R, Davis A, Verma V
Am Fam Physician 2020 Sep 1;102(5):298-304. PMID: 32866364
Hernandez-Prera JC
Semin Diagn Pathol 2020 Sep;37(5):228-233. Epub 2020 Mar 17 doi: 10.1053/j.semdp.2020.03.002. PMID: 32241577
Abdullah MI, Junit SM, Ng KL, Jayapalan JJ, Karikalan B, Hashim OH
Int J Med Sci 2019;16(3):450-460. Epub 2019 Feb 28 doi: 10.7150/ijms.29935. PMID: 30911279Free PMC Article

Therapy

Zhang R, Chen Y, Deng X, Qiao D, Li X, Yang H
J Robot Surg 2023 Oct;17(5):1933-1942. Epub 2023 Jun 26 doi: 10.1007/s11701-023-01655-2. PMID: 37358693
Narwani V, Kempf J, Lubitz S
Endocr Pract 2017 May;23(5):633. Epub 2016 Sep 15 doi: 10.4158/EP161474.VV. PMID: 27631845
Saberi S, Esfandiari NH
Endocr Pract 2015 May;21(5):558. Epub 2014 Oct 8 doi: 10.4158/EP14386.VV. PMID: 25297672
Santoro M, Carlomagno F
Cold Spring Harb Perspect Biol 2013 Dec 1;5(12):a009233. doi: 10.1101/cshperspect.a009233. PMID: 24296167Free PMC Article
Byrd JK, Yawn RJ, Wilhoit CS, Sora ND, Meyers L, Fernandes J, Day T
Curr Treat Options Oncol 2012 Mar;13(1):47-57. doi: 10.1007/s11864-011-0173-1. PMID: 22234582

Prognosis

Alzumaili B, Sadow PM
Genes (Basel) 2023 Jun 22;14(7) doi: 10.3390/genes14071314. PMID: 37510219Free PMC Article
Megwalu UC, Moon PK
Thyroid 2022 May;32(5):560-570. Epub 2022 Mar 15 doi: 10.1089/thy.2021.0662. PMID: 35132899
He J, Zhou M, Yin J, Wan J, Chu J, Jia J, Sheng J, Wang C, Yin H, He F
Mol Ther 2021 May 5;29(5):1821-1837. Epub 2021 Jan 21 doi: 10.1016/j.ymthe.2021.01.019. PMID: 33484966Free PMC Article
Kant R, Davis A, Verma V
Am Fam Physician 2020 Sep 1;102(5):298-304. PMID: 32866364
Abdullah MI, Junit SM, Ng KL, Jayapalan JJ, Karikalan B, Hashim OH
Int J Med Sci 2019;16(3):450-460. Epub 2019 Feb 28 doi: 10.7150/ijms.29935. PMID: 30911279Free PMC Article

Clinical prediction guides

Lin X, Zhao R, Bin Y, Huo R, Xue G, Wu J
Genomics 2024 Sep;116(5):110914. Epub 2024 Aug 10 doi: 10.1016/j.ygeno.2024.110914. PMID: 39128817
Lee JS, Lee JS, Yun HJ, Kim SM, Chang H, Lee YS, Chang HS, Park CS
J Clin Endocrinol Metab 2023 May 17;108(6):1370-1375. doi: 10.1210/clinem/dgac739. PMID: 36546348Free PMC Article
Zhu X, Xue C, Kang X, Jia X, Wang L, Younis MH, Liu D, Huo N, Han Y, Chen Z, Fu J, Zhou C, Yao X, Du Y, Cai W, Kang L, Lyu Z
Int J Biol Sci 2022;18(11):4372-4387. Epub 2022 Jul 4 doi: 10.7150/ijbs.72397. PMID: 35864964Free PMC Article
Kant R, Davis A, Verma V
Am Fam Physician 2020 Sep 1;102(5):298-304. PMID: 32866364
Nakamura S, Ishimori M, Yamakita N
Intern Med 2019 Feb 15;58(4):497-504. Epub 2018 Oct 17 doi: 10.2169/internalmedicine.0891-18. PMID: 30333389Free PMC Article

Recent systematic reviews

Silverii GA, Monami M, Gallo M, Ragni A, Prattichizzo F, Renzelli V, Ceriello A, Mannucci E
Diabetes Obes Metab 2024 Mar;26(3):891-900. Epub 2023 Nov 29 doi: 10.1111/dom.15382. PMID: 38018310
Moleti M, Aversa T, Crisafulli S, Trifirò G, Corica D, Pepe G, Cannavò L, Di Mauro M, Paola G, Fontana A, Calapai F, Cannavò S, Wasniewska M
Front Endocrinol (Lausanne) 2023;14:1270518. Epub 2023 Sep 19 doi: 10.3389/fendo.2023.1270518. PMID: 37795368Free PMC Article
Wei X, Wang X, Xiong J, Li C, Liao Y, Zhu Y, Mao J
Biomed Res Int 2022;2022:9959649. Epub 2022 May 18 doi: 10.1155/2022/9959649. PMID: 35647194Free PMC Article
van Dijk SPJ, Coerts HI, Gunput STG, van Velsen EFS, Medici M, Moelker A, Peeters RP, Verhoef C, van Ginhoven TM
JAMA Otolaryngol Head Neck Surg 2022 Apr 1;148(4):317-325. doi: 10.1001/jamaoto.2021.4381. PMID: 35142816Free PMC Article
Mao J, Zhang Q, Zhang H, Zheng K, Wang R, Wang G
Front Endocrinol (Lausanne) 2020;11:265. Epub 2020 May 15 doi: 10.3389/fendo.2020.00265. PMID: 32477264Free PMC Article

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Curated

    • NICE, 2022
      UK NICE Guideline NG230, Thyroid cancer: assessment and management

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