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Thyroid cancer, nonmedullary, 5(NMTC5)

MedGen UID:
895900
•Concept ID:
C4225292
•
Neoplastic Process
Synonym: NMTC5
 
Gene (location): HABP2 (10q25.3)
 
Monarch Initiative: MONDO:0014682
OMIM®: 616535

Definition

Nonmedullary thyroid cancer (NMTC) comprises cancer of follicular cell origin and accounts for more than 95% of all cases of thyroid cancer. Familial NMTC accounts for 3 to 9% of all cases of thyroid cancer and has an autosomal dominant mode of inheritance. Most cases of familial NMTC are papillary thyroid cancer (PTC), which is the most common type of thyroid cancer (summary by Gara et al., 2015). For a general phenotypic description and a discussion of genetic heterogeneity of NMTC, see NMTC1 (188550). [from OMIM]

Clinical features

From HPO
Familial nonmedullary thyroid carcinoma
MedGen UID:
502247
•Concept ID:
C3501843
•
Neoplastic Process
A rare non-syndromic form of thyroid cancer characterized by occurrence of thyroid carcinoma (TC) as the primary feature in a familial setting.
See: Feature record | Search on this feature

Professional guidelines

PubMed

Contemporary Management of Thyroid Nodules.
Kobaly K, Kim CS, Mandel SJ
Annu Rev Med 2022 Jan 27;73:517-528. Epub 2021 Aug 20 doi: 10.1146/annurev-med-042220-015032. PMID: 34416120
Contemporary Thyroid Nodule Evaluation and Management.
Grani G, Sponziello M, Pecce V, Ramundo V, Durante C
J Clin Endocrinol Metab 2020 Sep 1;105(9):2869-83. doi: 10.1210/clinem/dgaa322. PMID: 32491169Free PMC Article
Management Guidelines for Children with Thyroid Nodules and Differentiated Thyroid Cancer.
Francis GL, Waguespack SG, Bauer AJ, Angelos P, Benvenga S, Cerutti JM, Dinauer CA, Hamilton J, Hay ID, Luster M, Parisi MT, Rachmiel M, Thompson GB, Yamashita S; American Thyroid Association Guidelines Task Force
Thyroid 2015 Jul;25(7):716-59. doi: 10.1089/thy.2014.0460. PMID: 25900731Free PMC Article

Curated

UK NICE Guideline NG230, Thyroid cancer: assessment and management

Recent clinical studies

Etiology

Clinical characteristics and prognosis of familial nonmedullary thyroid carcinoma.
de Carlos Artajo J, Irigaray Echarri A, García Torres J, Pineda Arribas JJ, Ernaga Lorea A, Eguílaz Esparza N, Zubiría Gortázar JM, Anda Apiñániz E
Endocrinol Diabetes Nutr (Engl Ed) 2022 Apr;69(4):262-270. Epub 2022 Mar 16 doi: 10.1016/j.endien.2022.03.003. PMID: 35353680
Low-Risk Papillary Thyroid Cancer: Treatment De-Escalation and Cost Implications.
Paluskievicz CM, Chang DR, Blackburn KW, Turner DJ, Munir KM, Mullins CD, Olson JA Jr, Hu Y
J Surg Res 2022 Jul;275:273-280. Epub 2022 Mar 18 doi: 10.1016/j.jss.2022.01.019. PMID: 35306263
Is Familial Nonmedullary Thyroid Cancer A More Aggressive Type of Thyroid Cancer?
Muallem Kalmovich L, Jabarin B, Koren S, Or K, Marcus E, Tkacheva I, Benbassat C, Steinschneider M
Laryngoscope 2021 Feb;131(2):E677-E681. Epub 2020 Aug 6 doi: 10.1002/lary.28989. PMID: 32761812
Risk Factors for Lymph Node Metastasis in Papillary Thyroid Carcinoma: A Systematic Review and Meta-Analysis.
Mao J, Zhang Q, Zhang H, Zheng K, Wang R, Wang G
Front Endocrinol (Lausanne) 2020;11:265. Epub 2020 May 15 doi: 10.3389/fendo.2020.00265. PMID: 32477264Free PMC Article
Clinical behavior and genetics of nonsyndromic, familial nonmedullary thyroid cancer.
Bauer AJ
Front Horm Res 2013;41:141-8. Epub 2013 Mar 19 doi: 10.1159/000345674. PMID: 23652675

Diagnosis

American Thyroid Association Guidelines and National Trends in Management of Papillary Thyroid Carcinoma.
Gordon AJ, Dublin JC, Patel E, Papazian M, Chow MS, Persky MJ, Jacobson AS, Patel KN, Suh I, Morris LGT, Givi B
JAMA Otolaryngol Head Neck Surg 2022 Dec 1;148(12):1156-1163. doi: 10.1001/jamaoto.2022.3360. PMID: 36326739Free PMC Article
DNMT3B-mediated FAM111B methylation promotes papillary thyroid tumor glycolysis, growth and metastasis.
Zhu X, Xue C, Kang X, Jia X, Wang L, Younis MH, Liu D, Huo N, Han Y, Chen Z, Fu J, Zhou C, Yao X, Du Y, Cai W, Kang L, Lyu Z
Int J Biol Sci 2022;18(11):4372-4387. Epub 2022 Jul 4 doi: 10.7150/ijbs.72397. PMID: 35864964Free PMC Article
Papillary Thyroid Carcinoma: Current Position in Epidemiology, Genomics, and Classification.
Lam AK
Methods Mol Biol 2022;2534:1-15. doi: 10.1007/978-1-0716-2505-7_1. PMID: 35670964
Thyroid Nodules: Advances in Evaluation and Management.
Kant R, Davis A, Verma V
Am Fam Physician 2020 Sep 1;102(5):298-304. PMID: 32866364
Papillary Thyroid Cancer: Genetic Alterations and Molecular Biomarker Investigations.
Abdullah MI, Junit SM, Ng KL, Jayapalan JJ, Karikalan B, Hashim OH
Int J Med Sci 2019;16(3):450-460. Epub 2019 Feb 28 doi: 10.7150/ijms.29935. PMID: 30911279Free PMC Article

Therapy

Comparison of Lobectomy vs Total Thyroidectomy for Intermediate-Risk Papillary Thyroid Carcinoma With Lymph Node Metastasis.
Xu S, Huang H, Huang Y, Qian J, Wang X, Xu Z, Liu S, Liu J
JAMA Surg 2023 Jan 1;158(1):73-79. doi: 10.1001/jamasurg.2022.5781. PMID: 36449303Free PMC Article
American Thyroid Association Guidelines and National Trends in Management of Papillary Thyroid Carcinoma.
Gordon AJ, Dublin JC, Patel E, Papazian M, Chow MS, Persky MJ, Jacobson AS, Patel KN, Suh I, Morris LGT, Givi B
JAMA Otolaryngol Head Neck Surg 2022 Dec 1;148(12):1156-1163. doi: 10.1001/jamaoto.2022.3360. PMID: 36326739Free PMC Article
Molecular targets of tyrosine kinase inhibitors in thyroid cancer.
Fallahi P, Ferrari SM, Galdiero MR, Varricchi G, Elia G, Ragusa F, Paparo SR, Benvenga S, Antonelli A
Semin Cancer Biol 2022 Feb;79:180-196. Epub 2020 Nov 26 doi: 10.1016/j.semcancer.2020.11.013. PMID: 33249201
NTRK and RET fusion-directed therapy in pediatric thyroid cancer yields a tumor response and radioiodine uptake.
Lee YA, Lee H, Im SW, Song YS, Oh DY, Kang HJ, Won JK, Jung KC, Kwon D, Chung EJ, Hah JH, Paeng JC, Kim JH, Choi J, Kim OH, Oh JM, Ahn BC, Wirth LJ, Shin CH, Kim JI, Park YJ
J Clin Invest 2021 Sep 15;131(18) doi: 10.1172/JCI144847. PMID: 34237031Free PMC Article
Follicular cell-derived thyroid cancer.
Dralle H, Machens A, Basa J, Fatourechi V, Franceschi S, Hay ID, Nikiforov YE, Pacini F, Pasieka JL, Sherman SI
Nat Rev Dis Primers 2015 Dec 10;1:15077. doi: 10.1038/nrdp.2015.77. PMID: 27188261

Prognosis

DNMT3B-mediated FAM111B methylation promotes papillary thyroid tumor glycolysis, growth and metastasis.
Zhu X, Xue C, Kang X, Jia X, Wang L, Younis MH, Liu D, Huo N, Han Y, Chen Z, Fu J, Zhou C, Yao X, Du Y, Cai W, Kang L, Lyu Z
Int J Biol Sci 2022;18(11):4372-4387. Epub 2022 Jul 4 doi: 10.7150/ijbs.72397. PMID: 35864964Free PMC Article
Thyroid Cancer Incidence and Mortality Trends in the United States: 2000-2018.
Megwalu UC, Moon PK
Thyroid 2022 May;32(5):560-570. Epub 2022 Mar 15 doi: 10.1089/thy.2021.0662. PMID: 35132899
METTL3 restrains papillary thyroid cancer progression via m(6)A/c-Rel/IL-8-mediated neutrophil infiltration.
He J, Zhou M, Yin J, Wan J, Chu J, Jia J, Sheng J, Wang C, Yin H, He F
Mol Ther 2021 May 5;29(5):1821-1837. Epub 2021 Jan 21 doi: 10.1016/j.ymthe.2021.01.019. PMID: 33484966Free PMC Article
Thyroid Nodules: Advances in Evaluation and Management.
Kant R, Davis A, Verma V
Am Fam Physician 2020 Sep 1;102(5):298-304. PMID: 32866364
Papillary Thyroid Cancer: Genetic Alterations and Molecular Biomarker Investigations.
Abdullah MI, Junit SM, Ng KL, Jayapalan JJ, Karikalan B, Hashim OH
Int J Med Sci 2019;16(3):450-460. Epub 2019 Feb 28 doi: 10.7150/ijms.29935. PMID: 30911279Free PMC Article

Clinical prediction guides

American Thyroid Association Guidelines and National Trends in Management of Papillary Thyroid Carcinoma.
Gordon AJ, Dublin JC, Patel E, Papazian M, Chow MS, Persky MJ, Jacobson AS, Patel KN, Suh I, Morris LGT, Givi B
JAMA Otolaryngol Head Neck Surg 2022 Dec 1;148(12):1156-1163. doi: 10.1001/jamaoto.2022.3360. PMID: 36326739Free PMC Article
DNMT3B-mediated FAM111B methylation promotes papillary thyroid tumor glycolysis, growth and metastasis.
Zhu X, Xue C, Kang X, Jia X, Wang L, Younis MH, Liu D, Huo N, Han Y, Chen Z, Fu J, Zhou C, Yao X, Du Y, Cai W, Kang L, Lyu Z
Int J Biol Sci 2022;18(11):4372-4387. Epub 2022 Jul 4 doi: 10.7150/ijbs.72397. PMID: 35864964Free PMC Article
Thyroid Nodules: Advances in Evaluation and Management.
Kant R, Davis A, Verma V
Am Fam Physician 2020 Sep 1;102(5):298-304. PMID: 32866364
Risk Factors for Lymph Node Metastasis in Papillary Thyroid Carcinoma: A Systematic Review and Meta-Analysis.
Mao J, Zhang Q, Zhang H, Zheng K, Wang R, Wang G
Front Endocrinol (Lausanne) 2020;11:265. Epub 2020 May 15 doi: 10.3389/fendo.2020.00265. PMID: 32477264Free PMC Article
Clinical behavior and genetics of nonsyndromic, familial nonmedullary thyroid cancer.
Bauer AJ
Front Horm Res 2013;41:141-8. Epub 2013 Mar 19 doi: 10.1159/000345674. PMID: 23652675

Recent systematic reviews

Glucagon-like peptide-1 receptor agonists and risk of thyroid cancer: A systematic review and meta-analysis of randomized controlled trials.
Silverii GA, Monami M, Gallo M, Ragni A, Prattichizzo F, Renzelli V, Ceriello A, Mannucci E
Diabetes Obes Metab 2024 Mar;26(3):891-900. Epub 2023 Nov 29 doi: 10.1111/dom.15382. PMID: 38018310
Global incidence and prevalence of differentiated thyroid cancer in childhood: systematic review and meta-analysis.
Moleti M, Aversa T, Crisafulli S, Trifirò G, Corica D, Pepe G, Cannavò L, Di Mauro M, Paola G, Fontana A, Calapai F, Cannavò S, Wasniewska M
Front Endocrinol (Lausanne) 2023;14:1270518. Epub 2023 Sep 19 doi: 10.3389/fendo.2023.1270518. PMID: 37795368Free PMC Article
Risk and Prognostic Factors for BRAF(V600E) Mutations in Papillary Thyroid Carcinoma.
Wei X, Wang X, Xiong J, Li C, Liao Y, Zhu Y, Mao J
Biomed Res Int 2022;2022:9959649. Epub 2022 May 18 doi: 10.1155/2022/9959649. PMID: 35647194Free PMC Article
Assessment of Radiofrequency Ablation for Papillary Microcarcinoma of the Thyroid: A Systematic Review and Meta-analysis.
van Dijk SPJ, Coerts HI, Gunput STG, van Velsen EFS, Medici M, Moelker A, Peeters RP, Verhoef C, van Ginhoven TM
JAMA Otolaryngol Head Neck Surg 2022 Apr 1;148(4):317-325. doi: 10.1001/jamaoto.2021.4381. PMID: 35142816Free PMC Article
Risk Factors for Lymph Node Metastasis in Papillary Thyroid Carcinoma: A Systematic Review and Meta-Analysis.
Mao J, Zhang Q, Zhang H, Zheng K, Wang R, Wang G
Front Endocrinol (Lausanne) 2020;11:265. Epub 2020 May 15 doi: 10.3389/fendo.2020.00265. PMID: 32477264Free PMC Article

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    Curated

    • NICE, 2022
      UK NICE Guideline NG230, Thyroid cancer: assessment and management

    Reviews

    Related information

    • ClinVar
      Related medical variations
    • Gene
      Related information in NCBI Gene
    • GTR
      Related information in GTR
    • GTR(Clinical)
      Clinical tests in GTR
    • OMIM
      Related records in OMIM
    • OMIM(Genes)
      OMIM records containing genes associated with phenotypes registered in MedGen
    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

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