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Pituitary adenoma 3, multiple types(PITA3)

MedGen UID:
1620824
•Concept ID:
C4540135
•
Neoplastic Process
Synonyms: PITUITARY ADENOMA 3, ACTH-SECRETING, SOMATIC; PITUITARY ADENOMA 3, GROWTH HORMONE-SECRETING, SOMATIC
 
Gene (location): GNAS (20q13.32)
 
Monarch Initiative: MONDO:0054665
OMIM®: 617686

Definition

Somatic mutations in the GNAS gene have been found predominantly in GH-secreting pituitary adenomas but also in ACTH-secreting adenomas. Mutations in the GNAS gene have been found in about 40% of sporadic somatotrophin adenomas (summary by Mete and Lopes, 2017). For a general description and a discussion of genetic heterogeneity of pituitary adenomas, see PITA1 (102200). [from OMIM]

Professional guidelines

PubMed

Genotype and clinical phenotype characteristics of MAX germline mutation-associated pheochromocytoma/paraganglioma syndrome.
Lian B, Lu J, Fang X, Zhang Y, Wang W, He Y, Yu H, Li F, Wang J, Chen W, Qi X
Front Endocrinol (Lausanne) 2024;15:1442691. Epub 2024 Aug 30 doi: 10.3389/fendo.2024.1442691. PMID: 39279998Free PMC Article
The characteristics of and surgical treatment for pituitary adenomas in patients under 14 years old.
Zhao Y, Lian W, Xing B, Wang R
Clin Neurol Neurosurg 2019 Sep;184:105423. Epub 2019 Jul 12 doi: 10.1016/j.clineuro.2019.105423. PMID: 31376772
Pituitary gigantism: update on molecular biology and management.
Lodish MB, Trivellin G, Stratakis CA
Curr Opin Endocrinol Diabetes Obes 2016 Feb;23(1):72-80. doi: 10.1097/MED.0000000000000212. PMID: 26574647Free PMC Article

Recent clinical studies

Etiology

Comparison of neuroimaging features of histiocytic neoplasms with central nervous system involvement: a retrospective study of 121 adult patients.
Fan X, Liu T, Zhang Z, Sun J, Niu N, Mao C, Wang F, Li J, Zhou D, Cao X, Jin Z, Feng F
Eur Radiol 2023 Nov;33(11):8031-8042. Epub 2023 May 16 doi: 10.1007/s00330-023-09724-8. PMID: 37191919Free PMC Article
Overview of the 2022 WHO Classification of Pituitary Tumors.
Asa SL, Mete O, Perry A, Osamura RY
Endocr Pathol 2022 Mar;33(1):6-26. Epub 2022 Mar 15 doi: 10.1007/s12022-022-09703-7. PMID: 35291028
Epidemiology and Comorbidity of Adrenal Cushing Syndrome: A Nationwide Cohort Study.
Ahn CH, Kim JH, Park MY, Kim SW
J Clin Endocrinol Metab 2021 Mar 8;106(3):e1362-e1372. doi: 10.1210/clinem/dgaa752. PMID: 33075802
Genes involved in neuroendocrine tumor biology.
Hofsli E
Pituitary 2006;9(3):165-78. doi: 10.1007/s11102-006-0262-5. PMID: 17001466
Recent advances in clinical/molecular andrology.
Hafez B
Arch Androl 1998 May-Jun;40(3):187-210. doi: 10.3109/01485019808987943. PMID: 9583357

Diagnosis

Evaluation of autoantibody signatures in pituitary adenoma patients using human proteome arrays.
Banerjee A, Ray A, Barpanda A, Dash A, Gupta I, Nissa MU, Zhu H, Shah A, Duttagupta SP, Goel A, Srivastava S
Proteomics Clin Appl 2022 Nov;16(6):e2100111. Epub 2022 Sep 18 doi: 10.1002/prca.202100111. PMID: 35939377
Overview of the 2022 WHO Classification of Pituitary Tumors.
Asa SL, Mete O, Perry A, Osamura RY
Endocr Pathol 2022 Mar;33(1):6-26. Epub 2022 Mar 15 doi: 10.1007/s12022-022-09703-7. PMID: 35291028
Association of craniopharyngioma and pituitary adenoma.
Guaraldi F, Prencipe N, di Giacomo V, Scanarini M, Gasco V, Gardiman MP, Berton AM, Ghigo E, Grottoli S
Endocrine 2013 Aug;44(1):59-65. Epub 2013 Feb 2 doi: 10.1007/s12020-013-9892-3. PMID: 23377700
Pituitary blastoma.
Scheithauer BW, Kovacs K, Horvath E, Kim DS, Osamura RY, Ketterling RP, Lloyd RV, Kim OL
Acta Neuropathol 2008 Dec;116(6):657-66. Epub 2008 Jun 13 doi: 10.1007/s00401-008-0388-9. PMID: 18551299
Genes involved in neuroendocrine tumor biology.
Hofsli E
Pituitary 2006;9(3):165-78. doi: 10.1007/s11102-006-0262-5. PMID: 17001466

Therapy

Proton therapy and limited surgery for paediatric and adolescent patients with craniopharyngioma (RT2CR): a single-arm, phase 2 study.
Merchant TE, Hoehn ME, Khan RB, Sabin ND, Klimo P, Boop FA, Wu S, Li Y, Burghen EA, Jurbergs N, Sandler ES, Aldana PR, Indelicato DJ, Conklin HM
Lancet Oncol 2023 May;24(5):523-534. Epub 2023 Apr 18 doi: 10.1016/S1470-2045(23)00146-8. PMID: 37084748Free PMC Article
Epidemiology and Comorbidity of Adrenal Cushing Syndrome: A Nationwide Cohort Study.
Ahn CH, Kim JH, Park MY, Kim SW
J Clin Endocrinol Metab 2021 Mar 8;106(3):e1362-e1372. doi: 10.1210/clinem/dgaa752. PMID: 33075802
Sporadic and genetic forms of paediatric somatotropinoma: a retrospective analysis of seven cases and a review of the literature.
Nozières C, Berlier P, Dupuis C, Raynaud-Ravni C, Morel Y, Chazot FB, Nicolino M
Orphanet J Rare Dis 2011 Oct 24;6:67. doi: 10.1186/1750-1172-6-67. PMID: 22024364Free PMC Article
Somatostatin and dopamine-somatostatin multiple ligands directed towards somatostatin and dopamine receptors in pituitary adenomas.
Saveanu A, Gunz G, Guillen S, Dufour H, Culler MD, Jaquet P
Neuroendocrinology 2006;83(3-4):258-63. Epub 2006 Oct 13 doi: 10.1159/000095536. PMID: 17047391
Somatostatin analogs and radiopeptides in cancer therapy.
Froidevaux S, Eberle AN
Biopolymers 2002;66(3):161-83. doi: 10.1002/bip.10256. PMID: 12385036

Prognosis

Comparison of neuroimaging features of histiocytic neoplasms with central nervous system involvement: a retrospective study of 121 adult patients.
Fan X, Liu T, Zhang Z, Sun J, Niu N, Mao C, Wang F, Li J, Zhou D, Cao X, Jin Z, Feng F
Eur Radiol 2023 Nov;33(11):8031-8042. Epub 2023 May 16 doi: 10.1007/s00330-023-09724-8. PMID: 37191919Free PMC Article
Collision of Craniopharyngioma and Pituitary Adenoma: Comprehensive Review of an Extremely Rare Sellar Condition.
Hasegawa H, Jentoft ME, Young WF Jr, Lakomkin N, Van Gompel JJ, Link MJ, Atkinson JL, Meyer FB
World Neurosurg 2021 May;149:e51-e62. Epub 2021 Feb 26 doi: 10.1016/j.wneu.2021.02.091. PMID: 33647491
Epidemiology and Comorbidity of Adrenal Cushing Syndrome: A Nationwide Cohort Study.
Ahn CH, Kim JH, Park MY, Kim SW
J Clin Endocrinol Metab 2021 Mar 8;106(3):e1362-e1372. doi: 10.1210/clinem/dgaa752. PMID: 33075802
Malignant transformation in craniopharyngiomas.
Sofela AA, Hettige S, Curran O, Bassi S
Neurosurgery 2014 Sep;75(3):306-14; discussion 314. doi: 10.1227/NEU.0000000000000380. PMID: 24978859
Genes involved in neuroendocrine tumor biology.
Hofsli E
Pituitary 2006;9(3):165-78. doi: 10.1007/s11102-006-0262-5. PMID: 17001466

Clinical prediction guides

Comparison of neuroimaging features of histiocytic neoplasms with central nervous system involvement: a retrospective study of 121 adult patients.
Fan X, Liu T, Zhang Z, Sun J, Niu N, Mao C, Wang F, Li J, Zhou D, Cao X, Jin Z, Feng F
Eur Radiol 2023 Nov;33(11):8031-8042. Epub 2023 May 16 doi: 10.1007/s00330-023-09724-8. PMID: 37191919Free PMC Article
Zingerone Modulates Neuronal Voltage-Gated Na(+) and L-Type Ca(2+) Currents.
Lai MC, Wu SN, Huang CW
Int J Mol Sci 2022 Mar 14;23(6) doi: 10.3390/ijms23063123. PMID: 35328544Free PMC Article
Collision of Craniopharyngioma and Pituitary Adenoma: Comprehensive Review of an Extremely Rare Sellar Condition.
Hasegawa H, Jentoft ME, Young WF Jr, Lakomkin N, Van Gompel JJ, Link MJ, Atkinson JL, Meyer FB
World Neurosurg 2021 May;149:e51-e62. Epub 2021 Feb 26 doi: 10.1016/j.wneu.2021.02.091. PMID: 33647491
Endoscopic endonasal resection of nonfunctioning pituitary adenoma with radiological calcification.
Xie Z, Wang Q, Lu X
Pituitary 2019 Aug;22(4):381-386. doi: 10.1007/s11102-019-00967-7. PMID: 31093846
Genes involved in neuroendocrine tumor biology.
Hofsli E
Pituitary 2006;9(3):165-78. doi: 10.1007/s11102-006-0262-5. PMID: 17001466

Recent systematic reviews

The effect of exposure to radiofrequency fields on cancer risk in the general and working population: A systematic review of human observational studies - Part I: Most researched outcomes.
Karipidis K, Baaken D, Loney T, Blettner M, Brzozek C, Elwood M, Narh C, Orsini N, Röösli M, Paulo MS, Lagorio S
Environ Int 2024 Sep;191:108983. Epub 2024 Aug 30 doi: 10.1016/j.envint.2024.108983. PMID: 39241333
Collision of Craniopharyngioma and Pituitary Adenoma: Comprehensive Review of an Extremely Rare Sellar Condition.
Hasegawa H, Jentoft ME, Young WF Jr, Lakomkin N, Van Gompel JJ, Link MJ, Atkinson JL, Meyer FB
World Neurosurg 2021 May;149:e51-e62. Epub 2021 Feb 26 doi: 10.1016/j.wneu.2021.02.091. PMID: 33647491

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