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Astrocytoma IDH-mutant

MedGen UID:
1805924
•Concept ID:
C5669733
•
Neoplastic Process
Synonym: Astrocytoma, IDH-Mutant

Definition

An astrocytoma associated with IDH1 or IDH2 gene mutations and absence of 1p/19q codeletion. It is classified as grade 2, 3, or 4. [from NCI]

Professional guidelines

PubMed

Genomic characterization of IDH-mutant astrocytoma progression to grade 4 in the treatment setting.
Rautajoki KJ, Jaatinen S, Hartewig A, Tiihonen AM, Annala M, Salonen I, Valkonen M, Simola V, Vuorinen EM, Kivinen A, Rauhala MJ, Nurminen R, Maass KK, Lahtela SL, Jukkola A, Yli-Harja O, Helén P, Pajtler KW, Ruusuvuori P, Haapasalo J, Zhang W, Haapasalo H, Nykter M
Acta Neuropathol Commun 2023 Nov 6;11(1):176. doi: 10.1186/s40478-023-01669-9. PMID: 37932833Free PMC Article
Therapy for Diffuse Astrocytic and Oligodendroglial Tumors in Adults: ASCO-SNO Guideline.
Mohile NA, Messersmith H, Gatson NT, Hottinger AF, Lassman A, Morton J, Ney D, Nghiemphu PL, Olar A, Olson J, Perry J, Portnow J, Schiff D, Shannon A, Shih HA, Strowd R, van den Bent M, Ziu M, Blakeley J
J Clin Oncol 2022 Feb 1;40(4):403-426. Epub 2021 Dec 13 doi: 10.1200/JCO.21.02036. PMID: 34898238
IDH-Mutant Low-grade Glioma: Advances in Molecular Diagnosis, Management, and Future Directions.
Dono A, Ballester LY, Primdahl D, Esquenazi Y, Bhatia A
Curr Oncol Rep 2021 Jan 25;23(2):20. doi: 10.1007/s11912-020-01006-6. PMID: 33492489

Recent clinical studies

Etiology

Supramaximal versus gross total resection in Glioblastoma, IDH wild-type and Astrocytoma, IDH-mutant, grade 4, effect on overall and progression free survival: systematic review and meta-analysis.
Mier-García JF, Ospina-Santa S, Orozco-Mera J, Ma R, Plaha P
J Neurooncol 2023 Aug;164(1):31-41. Epub 2023 Aug 10 doi: 10.1007/s11060-023-04409-0. PMID: 37561356
Mismatch Repair Deficiency and Lynch Syndrome Among Adult Patients With Glioma.
Benusiglio PR, Elder F, Touat M, Perrier A, Sanson M, Colas C, Guerrini-Rousseau L, Tran DT, Trabelsi N, Carpentier C, Marie Y, Adam C, Bernier M, Cazals-Hatem D, Mokhtari K, Tran S, Mathon B, Capelle L, Dhooge M, Idbaih A, Alentorn A, Houillier C, Dehais C, Hoang-Xuan K, Cuzzubbo S, Carpentier A, Duval A, Coulet F, Bielle F
JCO Precis Oncol 2023 May;7:e2200525. doi: 10.1200/PO.22.00525. PMID: 37262394
Limited efficacy of temozolomide alone for astrocytoma, IDH-mutant, CNS WHO grades 2 or 3.
Weller J, Katzendobler S, Blobner J, Thiele F, Becker H, Quach S, Egensperger R, Niyazi M, Suchorska B, Thon N, Weller M, Tonn JC
J Neurooncol 2022 Oct;160(1):149-158. Epub 2022 Sep 16 doi: 10.1007/s11060-022-04128-y. PMID: 36112301Free PMC Article
Radiation Therapy for IDH-Mutant Grade 2 and Grade 3 Diffuse Glioma: An ASTRO Clinical Practice Guideline.
Halasz LM, Attia A, Bradfield L, Brat DJ, Kirkpatrick JP, Laack NN, Lalani N, Lebow ES, Liu AK, Niemeier HM, Palmer JD, Peters KB, Sheehan J, Thomas RP, Vora SA, Wahl DR, Weiss SE, Yeboa DN, Zhong J, Shih HA
Pract Radiat Oncol 2022 Sep-Oct;12(5):370-386. Epub 2022 May 31 doi: 10.1016/j.prro.2022.05.004. PMID: 35902341
Novel, improved grading system(s) for IDH-mutant astrocytic gliomas.
Shirahata M, Ono T, Stichel D, Schrimpf D, Reuss DE, Sahm F, Koelsche C, Wefers A, Reinhardt A, Huang K, Sievers P, Shimizu H, Nanjo H, Kobayashi Y, Miyake Y, Suzuki T, Adachi JI, Mishima K, Sasaki A, Nishikawa R, Bewerunge-Hudler M, Ryzhova M, Absalyamova O, Golanov A, Sinn P, Platten M, Jungk C, Winkler F, Wick A, Hänggi D, Unterberg A, Pfister SM, Jones DTW, van den Bent M, Hegi M, French P, Baumert BG, Stupp R, Gorlia T, Weller M, Capper D, Korshunov A, Herold-Mende C, Wick W, Louis DN, von Deimling A
Acta Neuropathol 2018 Jul;136(1):153-166. Epub 2018 Apr 23 doi: 10.1007/s00401-018-1849-4. PMID: 29687258

Diagnosis

Mismatch Repair Deficiency and Lynch Syndrome Among Adult Patients With Glioma.
Benusiglio PR, Elder F, Touat M, Perrier A, Sanson M, Colas C, Guerrini-Rousseau L, Tran DT, Trabelsi N, Carpentier C, Marie Y, Adam C, Bernier M, Cazals-Hatem D, Mokhtari K, Tran S, Mathon B, Capelle L, Dhooge M, Idbaih A, Alentorn A, Houillier C, Dehais C, Hoang-Xuan K, Cuzzubbo S, Carpentier A, Duval A, Coulet F, Bielle F
JCO Precis Oncol 2023 May;7:e2200525. doi: 10.1200/PO.22.00525. PMID: 37262394
Genomic profiles of IDH-mutant gliomas: MYCN-amplified IDH-mutant astrocytoma had the worst prognosis.
Lee K, Kim SI, Kim EE, Shim YM, Won JK, Park CK, Choi SH, Yun H, Lee H, Park SH
Sci Rep 2023 Apr 25;13(1):6761. doi: 10.1038/s41598-023-32153-y. PMID: 37185778Free PMC Article
Thirty years of progress in the management of low-grade gliomas.
van den Bent MJ
Rev Neurol (Paris) 2023 Jun;179(5):425-429. Epub 2023 Apr 5 doi: 10.1016/j.neurol.2023.03.001. PMID: 37029057
Therapy for Diffuse Astrocytic and Oligodendroglial Tumors in Adults: ASCO-SNO Guideline.
Mohile NA, Messersmith H, Gatson NT, Hottinger AF, Lassman A, Morton J, Ney D, Nghiemphu PL, Olar A, Olson J, Perry J, Portnow J, Schiff D, Shannon A, Shih HA, Strowd R, van den Bent M, Ziu M, Blakeley J
J Clin Oncol 2022 Feb 1;40(4):403-426. Epub 2021 Dec 13 doi: 10.1200/JCO.21.02036. PMID: 34898238
Diffuse Astrocytoma, IDH-Wildtype: A Dissolving Diagnosis.
Hasselblatt M, Jaber M, Reuss D, Grauer O, Bibo A, Terwey S, Schick U, Ebel H, Niederstadt T, Stummer W, von Deimling A, Paulus W
J Neuropathol Exp Neurol 2018 Jun 1;77(6):422-425. doi: 10.1093/jnen/nly012. PMID: 29444314

Therapy

Supramaximal versus gross total resection in Glioblastoma, IDH wild-type and Astrocytoma, IDH-mutant, grade 4, effect on overall and progression free survival: systematic review and meta-analysis.
Mier-García JF, Ospina-Santa S, Orozco-Mera J, Ma R, Plaha P
J Neurooncol 2023 Aug;164(1):31-41. Epub 2023 Aug 10 doi: 10.1007/s11060-023-04409-0. PMID: 37561356
Limited efficacy of temozolomide alone for astrocytoma, IDH-mutant, CNS WHO grades 2 or 3.
Weller J, Katzendobler S, Blobner J, Thiele F, Becker H, Quach S, Egensperger R, Niyazi M, Suchorska B, Thon N, Weller M, Tonn JC
J Neurooncol 2022 Oct;160(1):149-158. Epub 2022 Sep 16 doi: 10.1007/s11060-022-04128-y. PMID: 36112301Free PMC Article
Therapy for Diffuse Astrocytic and Oligodendroglial Tumors in Adults: ASCO-SNO Guideline.
Mohile NA, Messersmith H, Gatson NT, Hottinger AF, Lassman A, Morton J, Ney D, Nghiemphu PL, Olar A, Olson J, Perry J, Portnow J, Schiff D, Shannon A, Shih HA, Strowd R, van den Bent M, Ziu M, Blakeley J
J Clin Oncol 2022 Feb 1;40(4):403-426. Epub 2021 Dec 13 doi: 10.1200/JCO.21.02036. PMID: 34898238
Sporadic and Lynch syndrome-associated mismatch repair-deficient brain tumors.
Kim H, Lim KY, Park JW, Kang J, Won JK, Lee K, Shim Y, Park CK, Kim SK, Choi SH, Kim TM, Yun H, Park SH
Lab Invest 2022 Feb;102(2):160-171. Epub 2021 Nov 30 doi: 10.1038/s41374-021-00694-3. PMID: 34848827Free PMC Article
Beyond the World Health Organization classification of central nervous system tumors 2016: what are the new developments for gliomas from a clinician's perspective?
Weller M, Reifenberger G
Curr Opin Neurol 2020 Dec;33(6):701-706. doi: 10.1097/WCO.0000000000000871. PMID: 33177376

Prognosis

Novel insight into histological and molecular astrocytoma, IDH-mutant, Grade 4 by the updated WHO classification of central nervous system tumors.
Chen W, Guo S, Wang Y, Shi Y, Guo X, Liu D, Li Y, Wang Y, Xing H, Xia Y, Li J, Wu J, Liang T, Wang H, Liu Q, Jin S, Qu T, Li H, Yang T, Zhang K, Wang Y, Ma W
Cancer Med 2023 Sep;12(18):18666-18678. Epub 2023 Sep 5 doi: 10.1002/cam4.6476. PMID: 37667984Free PMC Article
Genomic profiles of IDH-mutant gliomas: MYCN-amplified IDH-mutant astrocytoma had the worst prognosis.
Lee K, Kim SI, Kim EE, Shim YM, Won JK, Park CK, Choi SH, Yun H, Lee H, Park SH
Sci Rep 2023 Apr 25;13(1):6761. doi: 10.1038/s41598-023-32153-y. PMID: 37185778Free PMC Article
IDH-mutant diffuse gliomas: tips and tricks in the era of genomic tumor classification.
Ammendola S, Broggi G, Barresi V
Histol Histopathol 2023 Jul;38(7):739-753. Epub 2023 Jan 9 doi: 10.14670/HH-18-582. PMID: 36651583
Therapy for Diffuse Astrocytic and Oligodendroglial Tumors in Adults: ASCO-SNO Guideline.
Mohile NA, Messersmith H, Gatson NT, Hottinger AF, Lassman A, Morton J, Ney D, Nghiemphu PL, Olar A, Olson J, Perry J, Portnow J, Schiff D, Shannon A, Shih HA, Strowd R, van den Bent M, Ziu M, Blakeley J
J Clin Oncol 2022 Feb 1;40(4):403-426. Epub 2021 Dec 13 doi: 10.1200/JCO.21.02036. PMID: 34898238
Novel, improved grading system(s) for IDH-mutant astrocytic gliomas.
Shirahata M, Ono T, Stichel D, Schrimpf D, Reuss DE, Sahm F, Koelsche C, Wefers A, Reinhardt A, Huang K, Sievers P, Shimizu H, Nanjo H, Kobayashi Y, Miyake Y, Suzuki T, Adachi JI, Mishima K, Sasaki A, Nishikawa R, Bewerunge-Hudler M, Ryzhova M, Absalyamova O, Golanov A, Sinn P, Platten M, Jungk C, Winkler F, Wick A, Hänggi D, Unterberg A, Pfister SM, Jones DTW, van den Bent M, Hegi M, French P, Baumert BG, Stupp R, Gorlia T, Weller M, Capper D, Korshunov A, Herold-Mende C, Wick W, Louis DN, von Deimling A
Acta Neuropathol 2018 Jul;136(1):153-166. Epub 2018 Apr 23 doi: 10.1007/s00401-018-1849-4. PMID: 29687258

Clinical prediction guides

Novel insight into histological and molecular astrocytoma, IDH-mutant, Grade 4 by the updated WHO classification of central nervous system tumors.
Chen W, Guo S, Wang Y, Shi Y, Guo X, Liu D, Li Y, Wang Y, Xing H, Xia Y, Li J, Wu J, Liang T, Wang H, Liu Q, Jin S, Qu T, Li H, Yang T, Zhang K, Wang Y, Ma W
Cancer Med 2023 Sep;12(18):18666-18678. Epub 2023 Sep 5 doi: 10.1002/cam4.6476. PMID: 37667984Free PMC Article
Brain tumour genetic network signatures of survival.
Ruffle JK, Mohinta S, Pombo G, Gray R, Kopanitsa V, Lee F, Brandner S, Hyare H, Nachev P
Brain 2023 Nov 2;146(11):4736-4754. doi: 10.1093/brain/awad199. PMID: 37665980Free PMC Article
IDH-mutant diffuse gliomas: tips and tricks in the era of genomic tumor classification.
Ammendola S, Broggi G, Barresi V
Histol Histopathol 2023 Jul;38(7):739-753. Epub 2023 Jan 9 doi: 10.14670/HH-18-582. PMID: 36651583
Therapy for Diffuse Astrocytic and Oligodendroglial Tumors in Adults: ASCO-SNO Guideline.
Mohile NA, Messersmith H, Gatson NT, Hottinger AF, Lassman A, Morton J, Ney D, Nghiemphu PL, Olar A, Olson J, Perry J, Portnow J, Schiff D, Shannon A, Shih HA, Strowd R, van den Bent M, Ziu M, Blakeley J
J Clin Oncol 2022 Feb 1;40(4):403-426. Epub 2021 Dec 13 doi: 10.1200/JCO.21.02036. PMID: 34898238
Novel, improved grading system(s) for IDH-mutant astrocytic gliomas.
Shirahata M, Ono T, Stichel D, Schrimpf D, Reuss DE, Sahm F, Koelsche C, Wefers A, Reinhardt A, Huang K, Sievers P, Shimizu H, Nanjo H, Kobayashi Y, Miyake Y, Suzuki T, Adachi JI, Mishima K, Sasaki A, Nishikawa R, Bewerunge-Hudler M, Ryzhova M, Absalyamova O, Golanov A, Sinn P, Platten M, Jungk C, Winkler F, Wick A, Hänggi D, Unterberg A, Pfister SM, Jones DTW, van den Bent M, Hegi M, French P, Baumert BG, Stupp R, Gorlia T, Weller M, Capper D, Korshunov A, Herold-Mende C, Wick W, Louis DN, von Deimling A
Acta Neuropathol 2018 Jul;136(1):153-166. Epub 2018 Apr 23 doi: 10.1007/s00401-018-1849-4. PMID: 29687258

Recent systematic reviews

Supramaximal versus gross total resection in Glioblastoma, IDH wild-type and Astrocytoma, IDH-mutant, grade 4, effect on overall and progression free survival: systematic review and meta-analysis.
Mier-García JF, Ospina-Santa S, Orozco-Mera J, Ma R, Plaha P
J Neurooncol 2023 Aug;164(1):31-41. Epub 2023 Aug 10 doi: 10.1007/s11060-023-04409-0. PMID: 37561356
Radiation Therapy for IDH-Mutant Grade 2 and Grade 3 Diffuse Glioma: An ASTRO Clinical Practice Guideline.
Halasz LM, Attia A, Bradfield L, Brat DJ, Kirkpatrick JP, Laack NN, Lalani N, Lebow ES, Liu AK, Niemeier HM, Palmer JD, Peters KB, Sheehan J, Thomas RP, Vora SA, Wahl DR, Weiss SE, Yeboa DN, Zhong J, Shih HA
Pract Radiat Oncol 2022 Sep-Oct;12(5):370-386. Epub 2022 May 31 doi: 10.1016/j.prro.2022.05.004. PMID: 35902341
Therapy for Diffuse Astrocytic and Oligodendroglial Tumors in Adults: ASCO-SNO Guideline.
Mohile NA, Messersmith H, Gatson NT, Hottinger AF, Lassman A, Morton J, Ney D, Nghiemphu PL, Olar A, Olson J, Perry J, Portnow J, Schiff D, Shannon A, Shih HA, Strowd R, van den Bent M, Ziu M, Blakeley J
J Clin Oncol 2022 Feb 1;40(4):403-426. Epub 2021 Dec 13 doi: 10.1200/JCO.21.02036. PMID: 34898238

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