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Infantile epilepsy syndrome

MedGen UID:
1826124
Concept ID:
C5681523
Disease or Syndrome
Synonyms: epilepsy syndrome of infancy; infantile epilepsy syndrome; infantile onset epilepsy syndrome
 
Monarch Initiative: MONDO:0020071
Orphanet: ORPHA98258

Definition

An epilepsy syndrome that occurs between 28 days to one year of life. [from MONDO]

Professional guidelines

PubMed

Zuberi SM, Wirrell E, Yozawitz E, Wilmshurst JM, Specchio N, Riney K, Pressler R, Auvin S, Samia P, Hirsch E, Galicchio S, Triki C, Snead OC, Wiebe S, Cross JH, Tinuper P, Scheffer IE, Perucca E, Moshé SL, Nabbout R
Epilepsia 2022 Jun;63(6):1349-1397. Epub 2022 May 3 doi: 10.1111/epi.17239. PMID: 35503712
Wirrell EC, Hood V, Knupp KG, Meskis MA, Nabbout R, Scheffer IE, Wilmshurst J, Sullivan J
Epilepsia 2022 Jul;63(7):1761-1777. Epub 2022 May 12 doi: 10.1111/epi.17274. PMID: 35490361Free PMC Article
Katyayan A, Diaz-Medina G
Neurol Clin 2021 Aug;39(3):779-795. doi: 10.1016/j.ncl.2021.04.002. PMID: 34215386

Recent clinical studies

Etiology

Wang YQ, Fang ZX, Zhang YW, Xie LL, Jiang L
Seizure 2020 Oct;81:36-42. Epub 2020 Jul 18 doi: 10.1016/j.seizure.2020.07.011. PMID: 32712377
Bowser LE, Young M, Wenger OK, Ammous Z, Brigatti KW, Carson VJ, Moser T, Deline J, Aoki K, Morlet T, Scott EM, Puffenberger EG, Robinson DL, Hendrickson C, Salvin J, Gottlieb S, Heaps AD, Tiemeyer M, Strauss KA
Mol Genet Metab 2019 Apr;126(4):475-488. Epub 2019 Jan 21 doi: 10.1016/j.ymgme.2019.01.013. PMID: 30691927
O'Callaghan FJ, Edwards SW, Alber FD, Hancock E, Johnson AL, Kennedy CR, Likeman M, Lux AL, Mackay M, Mallick AA, Newton RW, Nolan M, Pressler R, Rating D, Schmitt B, Verity CM, Osborne JP; participating investigators
Lancet Neurol 2017 Jan;16(1):33-42. Epub 2016 Nov 10 doi: 10.1016/S1474-4422(16)30294-0. PMID: 27838190
Wang H, Wang A, Wang D, Bright A, Sency V, Zhou A, Xin B
Clin Genet 2016 May;89(5):625-9. Epub 2016 Jan 20 doi: 10.1111/cge.12703. PMID: 26649472

Diagnosis

Dookwah M, Wagner SK, Ishihara M, Yu SH, Ulrichs H, Kulik MJ, Zeltner N, Dalton S, Strauss KA, Aoki K, Steet R, Tiemeyer M
Hum Mol Genet 2023 Dec 1;32(24):3323-3341. doi: 10.1093/hmg/ddad146. PMID: 37676252Free PMC Article
Watanabe S, Lei M, Nakagawa E, Takeshita E, Inamori KI, Shishido F, Sasaki M, Mitsuhashi S, Matsumoto N, Kimura Y, Iwasaki M, Takahashi Y, Mizusawa H, Migita O, Ohno I, Inokuchi JI
Brain Dev 2023 May;45(5):270-277. Epub 2023 Jan 21 doi: 10.1016/j.braindev.2023.01.002. PMID: 36690566
Inamori KI, Inokuchi JI
Int J Mol Sci 2022 May 11;23(10) doi: 10.3390/ijms23105368. PMID: 35628171Free PMC Article
O'Callaghan FJ, Edwards SW, Alber FD, Hancock E, Johnson AL, Kennedy CR, Likeman M, Lux AL, Mackay M, Mallick AA, Newton RW, Nolan M, Pressler R, Rating D, Schmitt B, Verity CM, Osborne JP; participating investigators
Lancet Neurol 2017 Jan;16(1):33-42. Epub 2016 Nov 10 doi: 10.1016/S1474-4422(16)30294-0. PMID: 27838190
Wang H, Bright A, Xin B, Bockoven JR, Paller AS
Am J Med Genet A 2013 Apr;161A(4):875-9. Epub 2013 Feb 22 doi: 10.1002/ajmg.a.35826. PMID: 23436467

Therapy

Yang H, Brown RH Jr, Wang D, Strauss KA, Gao G
Trends Mol Med 2021 Jun;27(6):520-523. Epub 2021 Mar 10 doi: 10.1016/j.molmed.2021.02.004. PMID: 33714697Free PMC Article
O'Callaghan FJ, Edwards SW, Alber FD, Hancock E, Johnson AL, Kennedy CR, Likeman M, Lux AL, Mackay M, Mallick AA, Newton RW, Nolan M, Pressler R, Rating D, Schmitt B, Verity CM, Osborne JP; participating investigators
Lancet Neurol 2017 Jan;16(1):33-42. Epub 2016 Nov 10 doi: 10.1016/S1474-4422(16)30294-0. PMID: 27838190
Dalic L, Mullen SA, Roulet Perez E, Scheffer I
Dev Med Child Neurol 2015 Feb;57(2):200-2. Epub 2014 Sep 22 doi: 10.1111/dmcn.12593. PMID: 25243660

Prognosis

Watanabe S, Lei M, Nakagawa E, Takeshita E, Inamori KI, Shishido F, Sasaki M, Mitsuhashi S, Matsumoto N, Kimura Y, Iwasaki M, Takahashi Y, Mizusawa H, Migita O, Ohno I, Inokuchi JI
Brain Dev 2023 May;45(5):270-277. Epub 2023 Jan 21 doi: 10.1016/j.braindev.2023.01.002. PMID: 36690566
O'Callaghan FJ, Edwards SW, Alber FD, Hancock E, Johnson AL, Kennedy CR, Likeman M, Lux AL, Mackay M, Mallick AA, Newton RW, Nolan M, Pressler R, Rating D, Schmitt B, Verity CM, Osborne JP; participating investigators
Lancet Neurol 2017 Jan;16(1):33-42. Epub 2016 Nov 10 doi: 10.1016/S1474-4422(16)30294-0. PMID: 27838190

Clinical prediction guides

Bowser LE, Young M, Wenger OK, Ammous Z, Brigatti KW, Carson VJ, Moser T, Deline J, Aoki K, Morlet T, Scott EM, Puffenberger EG, Robinson DL, Hendrickson C, Salvin J, Gottlieb S, Heaps AD, Tiemeyer M, Strauss KA
Mol Genet Metab 2019 Apr;126(4):475-488. Epub 2019 Jan 21 doi: 10.1016/j.ymgme.2019.01.013. PMID: 30691927
Inokuchi JI, Go S, Yoshikawa M, Strauss K
Biochim Biophys Acta Gen Subj 2017 Oct;1861(10):2485-2493. Epub 2017 May 30 doi: 10.1016/j.bbagen.2017.05.025. PMID: 28571946
Fragaki K, Ait-El-Mkadem S, Chaussenot A, Gire C, Mengual R, Bonesso L, Bénéteau M, Ricci JE, Desquiret-Dumas V, Procaccio V, Rötig A, Paquis-Flucklinger V
Eur J Hum Genet 2013 May;21(5):528-34. Epub 2012 Sep 19 doi: 10.1038/ejhg.2012.202. PMID: 22990144Free PMC Article

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