U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Fatty liver disease, protection from(FLDP)

MedGen UID:
1824027
Concept ID:
C5774254
Finding
Synonym: FLDP
 
Gene (location): HSD17B13 (4q22.1)
 
OMIM®: 620116

Definition

Chronic liver disease, including alcoholic and nonalcoholic fatty liver disease, can progress to cirrhosis in some individuals. Patients with FLDP show protection against the progression to chronic liver disease from simple steatosis (summary by Abul-Husn et al., 2018). [from OMIM]

Professional guidelines

PubMed

Tapper EB, Parikh ND
JAMA 2023 May 9;329(18):1589-1602. doi: 10.1001/jama.2023.5997. PMID: 37159031Free PMC Article
Rong L, Zou J, Ran W, Qi X, Chen Y, Cui H, Guo J
Front Endocrinol (Lausanne) 2022;13:1087260. Epub 2023 Jan 16 doi: 10.3389/fendo.2022.1087260. PMID: 36726464Free PMC Article
Pouwels S, Sakran N, Graham Y, Leal A, Pintar T, Yang W, Kassir R, Singhal R, Mahawar K, Ramnarain D
BMC Endocr Disord 2022 Mar 14;22(1):63. doi: 10.1186/s12902-022-00980-1. PMID: 35287643Free PMC Article

Recent clinical studies

Etiology

Li H, Humphreys BD
J Clin Invest 2024 Feb 15;134(4) doi: 10.1172/JCI178125. PMID: 38357930Free PMC Article
Mantovani A, Dalbeni A
Int J Mol Sci 2021 Feb 26;22(5) doi: 10.3390/ijms22052350. PMID: 33652942Free PMC Article
Abenavoli L, Boccuto L, Federico A, Dallio M, Loguercio C, Di Renzo L, De Lorenzo A
Int J Environ Res Public Health 2019 Aug 21;16(17) doi: 10.3390/ijerph16173011. PMID: 31438482Free PMC Article
Rinella ME
JAMA 2015 Jun 9;313(22):2263-73. doi: 10.1001/jama.2015.5370. PMID: 26057287
Ohashi K, Yuasa D, Shibata R, Murohara T, Ouchi N
Endocr Metab Immune Disord Drug Targets 2015;15(2):145-50. doi: 10.2174/1871530315666150316122709. PMID: 25772181

Diagnosis

Gao R, Li Y, Xu Z, Zhang F, Xu J, Hu Y, Yin J, Yang K, Sun L, Wang Q, He X, Huang K
Hepatology 2023 Dec 1;78(6):1800-1815. Epub 2023 Jan 19 doi: 10.1097/HEP.0000000000000279. PMID: 36651176
Pouwels S, Sakran N, Graham Y, Leal A, Pintar T, Yang W, Kassir R, Singhal R, Mahawar K, Ramnarain D
BMC Endocr Disord 2022 Mar 14;22(1):63. doi: 10.1186/s12902-022-00980-1. PMID: 35287643Free PMC Article
Thyfault JP, Bergouignan A
Diabetologia 2020 Aug;63(8):1464-1474. Epub 2020 Jun 11 doi: 10.1007/s00125-020-05177-6. PMID: 32529412Free PMC Article
Brunner KT, Henneberg CJ, Wilechansky RM, Long MT
Curr Obes Rep 2019 Sep;8(3):220-228. doi: 10.1007/s13679-019-00345-1. PMID: 30945129Free PMC Article
Rinella ME
JAMA 2015 Jun 9;313(22):2263-73. doi: 10.1001/jama.2015.5370. PMID: 26057287

Therapy

Pouwels S, Sakran N, Graham Y, Leal A, Pintar T, Yang W, Kassir R, Singhal R, Mahawar K, Ramnarain D
BMC Endocr Disord 2022 Mar 14;22(1):63. doi: 10.1186/s12902-022-00980-1. PMID: 35287643Free PMC Article
Mantovani A, Dalbeni A
Int J Mol Sci 2021 Feb 26;22(5) doi: 10.3390/ijms22052350. PMID: 33652942Free PMC Article
Lan T, Yu Y, Zhang J, Li H, Weng Q, Jiang S, Tian S, Xu T, Hu S, Yang G, Zhang Y, Wang W, Wang L, Zhu Q, Rong X, Guo J
Hepatology 2021 Aug;74(2):686-703. doi: 10.1002/hep.31749. PMID: 33576035Free PMC Article
Gillessen A, Schmidt HH
Adv Ther 2020 Apr;37(4):1279-1301. Epub 2020 Feb 17 doi: 10.1007/s12325-020-01251-y. PMID: 32065376Free PMC Article
Rinella ME
JAMA 2015 Jun 9;313(22):2263-73. doi: 10.1001/jama.2015.5370. PMID: 26057287

Prognosis

Sveinbjornsson G, Ulfarsson MO, Thorolfsdottir RB, Jonsson BA, Einarsson E, Gunnlaugsson G, Rognvaldsson S, Arnar DO, Baldvinsson M, Bjarnason RG; DBDS Genomic consortium, Eiriksdottir T, Erikstrup C, Ferkingstad E, Halldorsson GH, Helgason H, Helgadottir A, Hindhede L, Hjorleifsson G, Jones D, Knowlton KU, Lund SH, Melsted P, Norland K, Olafsson I, Olafsson S, Oskarsson GR, Ostrowski SR, Pedersen OB, Snaebjarnarson AS, Sigurdsson E, Steinthorsdottir V, Schwinn M, Thorgeirsson G, Thorleifsson G, Jonsdottir I, Bundgaard H, Nadauld L, Bjornsson ES, Rulifson IC, Rafnar T, Norddahl GL, Thorsteinsdottir U, Sulem P, Gudbjartsson DF, Holm H, Stefansson K
Nat Genet 2022 Nov;54(11):1652-1663. Epub 2022 Oct 24 doi: 10.1038/s41588-022-01199-5. PMID: 36280732Free PMC Article
Pouwels S, Sakran N, Graham Y, Leal A, Pintar T, Yang W, Kassir R, Singhal R, Mahawar K, Ramnarain D
BMC Endocr Disord 2022 Mar 14;22(1):63. doi: 10.1186/s12902-022-00980-1. PMID: 35287643Free PMC Article
Pushpanathan P, Mathew GS, Selvarajan S, Seshadri KG, Srikanth P
Indian J Med Microbiol 2019 Apr-Jun;37(2):268-277. doi: 10.4103/ijmm.IJMM_19_373. PMID: 31745030
Nagao M, Nakajima H, Toh R, Hirata KI, Ishida T
J Atheroscler Thromb 2018 Oct 1;25(10):985-993. Epub 2018 Aug 27 doi: 10.5551/jat.RV17025. PMID: 30146614Free PMC Article
Rinella ME
JAMA 2015 Jun 9;313(22):2263-73. doi: 10.1001/jama.2015.5370. PMID: 26057287

Clinical prediction guides

Pouwels S, Sakran N, Graham Y, Leal A, Pintar T, Yang W, Kassir R, Singhal R, Mahawar K, Ramnarain D
BMC Endocr Disord 2022 Mar 14;22(1):63. doi: 10.1186/s12902-022-00980-1. PMID: 35287643Free PMC Article
Gillessen A, Schmidt HH
Adv Ther 2020 Apr;37(4):1279-1301. Epub 2020 Feb 17 doi: 10.1007/s12325-020-01251-y. PMID: 32065376Free PMC Article
Brunner KT, Henneberg CJ, Wilechansky RM, Long MT
Curr Obes Rep 2019 Sep;8(3):220-228. doi: 10.1007/s13679-019-00345-1. PMID: 30945129Free PMC Article
Santhekadur PK, Kumar DP, Sanyal AJ
J Hepatol 2018 Feb;68(2):230-237. Epub 2017 Nov 9 doi: 10.1016/j.jhep.2017.10.031. PMID: 29128391Free PMC Article
Rinella ME
JAMA 2015 Jun 9;313(22):2263-73. doi: 10.1001/jama.2015.5370. PMID: 26057287

Recent systematic reviews

Simpson TC, Clarkson JE, Worthington HV, MacDonald L, Weldon JC, Needleman I, Iheozor-Ejiofor Z, Wild SH, Qureshi A, Walker A, Patel VA, Boyers D, Twigg J
Cochrane Database Syst Rev 2022 Apr 14;4(4):CD004714. doi: 10.1002/14651858.CD004714.pub4. PMID: 35420698Free PMC Article
Abenavoli L, Milanovic M, Procopio AC, Spampinato G, Maruca G, Perrino EV, Mannino GC, Fagoonee S, Luzza F, Musarella CM
Minerva Med 2021 Oct;112(5):641-650. Epub 2020 Jul 28 doi: 10.23736/S0026-4806.20.06873-1. PMID: 32729704
Basson AR, Chen C, Sagl F, Trotter A, Bederman I, Gomez-Nguyen A, Sundrud MS, Ilic S, Cominelli F, Rodriguez-Palacios A
Front Immunol 2020;11:604989. Epub 2021 Feb 2 doi: 10.3389/fimmu.2020.604989. PMID: 33603741Free PMC Article
Gillessen A, Schmidt HH
Adv Ther 2020 Apr;37(4):1279-1301. Epub 2020 Feb 17 doi: 10.1007/s12325-020-01251-y. PMID: 32065376Free PMC Article
Rinella ME
JAMA 2015 Jun 9;313(22):2263-73. doi: 10.1001/jama.2015.5370. PMID: 26057287

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Recent activity

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...