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Combined low LDL and fibrinogen(CLDLFIB)

MedGen UID:
1841120
•Concept ID:
C5830484
•
Finding
Synonym: CLDLFIB
 
Gene (location): B4GALT1 (9p21.1)
 
Monarch Initiative: MONDO:0957260
OMIM®: 620364

Clinical features

From HPO
Hypofibrinogenemia
MedGen UID:
107511
•Concept ID:
C0553681
•
Disease or Syndrome
Decreased concentration of fibrinogen in the blood.
See: Feature record | Search on this feature
Elevated circulating aspartate aminotransferase concentration
MedGen UID:
57497
•Concept ID:
C0151904
•
Finding
The concentration of aspartate aminotransferase (AST) in the blood circulation is above the upper limit of normal.
See: Feature record | Search on this feature
Decreased LDL cholesterol concentration
MedGen UID:
776554
•Concept ID:
C0853085
•
Finding
An decreased concentration of low-density lipoprotein cholesterol in the blood.
See: Feature record | Search on this feature
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Professional guidelines

PubMed

Evaluation of efficacy and safety of Reteplase and Alteplase in the treatment of hyper-acute cerebral infarction.
Lin ZJ, Qiu HY, Tong XX, Guo Y, Han MF, Yang CS, Lin KH, Wu J, Li X, Yang Y
Biosci Rep 2018 Feb 28;38(1) Epub 2018 Jan 17 doi: 10.1042/BSR20170730. PMID: 29263145Free PMC Article
Clinical implications of the IMPROVE-IT trial in the light of current and future lipid-lowering treatment options.
Serban MC, Banach M, Mikhailidis DP
Expert Opin Pharmacother 2016;17(3):369-80. Epub 2015 Nov 30 doi: 10.1517/14656566.2016.1118055. PMID: 26559810
Management issues in the metabolic syndrome.
Deedwania PC, Gupta R
J Assoc Physicians India 2006 Oct;54:797-810. PMID: 17214277

Recent clinical studies

Etiology

Hypertriglyceridemia: a too long unfairly neglected major cardiovascular risk factor.
Tenenbaum A, Klempfner R, Fisman EZ
Cardiovasc Diabetol 2014 Dec 4;13:159. doi: 10.1186/s12933-014-0159-y. PMID: 25471221Free PMC Article
Fenofibrate: a review of its use in dyslipidaemia.
McKeage K, Keating GM
Drugs 2011 Oct 1;71(14):1917-46. doi: 10.2165/11208090-000000000-00000. PMID: 21942979
Management issues in the metabolic syndrome.
Deedwania PC, Gupta R
J Assoc Physicians India 2006 Oct;54:797-810. PMID: 17214277
Contraception in older woman.
Volpe A, Silferi M, Genazzani AD, Genazzani AR
Contraception 1993 Mar;47(3):229-39. doi: 10.1016/0010-7824(93)90040-e. PMID: 8462314
Oral contraceptives and coronary heart disease.
Wynn V
J Reprod Med 1991 Mar;36(3 Suppl):219-25. PMID: 2046075

Diagnosis

Lipid profile and atherogenic indices in patients with stable chronic obstructive pulmonary disease.
Markelić I, Hlapčić I, Rogić D, Rako I, Samaržija M, Popović-Grle S, Rumora L, Vukić Dugac A
Nutr Metab Cardiovasc Dis 2021 Jan 4;31(1):153-161. Epub 2020 Aug 5 doi: 10.1016/j.numecd.2020.07.039. PMID: 32981798
Vascular inflammation and metabolic activity in hematopoietic organs and liver in familial combined hyperlipidemia and heterozygous familial hypercholesterolemia.
Toutouzas K, Skoumas J, Koutagiar I, Benetos G, Pianou N, Georgakopoulos A, Galanakos S, Antonopoulos A, Drakopoulou M, Oikonomou EK, Kafouris P, Athanasiadis E, Metaxas M, Spyrou G, Pallantza Z, Galiatsatos N, Aggeli C, Antoniades C, Keramida G, Peters AM, Anagnostopoulos CD, Tousoulis D
J Clin Lipidol 2018 Jan-Feb;12(1):33-43. Epub 2017 Nov 2 doi: 10.1016/j.jacl.2017.10.019. PMID: 29174439
Vascular and metabolic effects of omega-3 fatty acids combined with fenofibrate in patients with hypertriglyceridemia.
Koh KK, Oh PC, Sakuma I, Lee Y, Han SH, Shin EK
Int J Cardiol 2016 Oct 15;221:342-6. Epub 2016 Jul 5 doi: 10.1016/j.ijcard.2016.07.038. PMID: 27424313
Balanced pan-PPAR activator bezafibrate in combination with statin: comprehensive lipids control and diabetes prevention?
Tenenbaum A, Fisman EZ
Cardiovasc Diabetol 2012 Nov 14;11:140. doi: 10.1186/1475-2840-11-140. PMID: 23150952Free PMC Article
Prevention and treatment of the metabolic syndrome.
Daskalopoulou SS, Mikhailidis DP, Elisaf M
Angiology 2004 Nov-Dec;55(6):589-612. doi: 10.1177/00033197040550i601. PMID: 15547646

Therapy

Lipid profile and atherogenic indices in patients with stable chronic obstructive pulmonary disease.
Markelić I, Hlapčić I, Rogić D, Rako I, Samaržija M, Popović-Grle S, Rumora L, Vukić Dugac A
Nutr Metab Cardiovasc Dis 2021 Jan 4;31(1):153-161. Epub 2020 Aug 5 doi: 10.1016/j.numecd.2020.07.039. PMID: 32981798
Hypertriglyceridemia: a too long unfairly neglected major cardiovascular risk factor.
Tenenbaum A, Klempfner R, Fisman EZ
Cardiovasc Diabetol 2014 Dec 4;13:159. doi: 10.1186/s12933-014-0159-y. PMID: 25471221Free PMC Article
Fenofibrate: a review of its use in dyslipidaemia.
McKeage K, Keating GM
Drugs 2011 Oct 1;71(14):1917-46. doi: 10.2165/11208090-000000000-00000. PMID: 21942979
Contraception in older woman.
Volpe A, Silferi M, Genazzani AD, Genazzani AR
Contraception 1993 Mar;47(3):229-39. doi: 10.1016/0010-7824(93)90040-e. PMID: 8462314
Oral contraceptives and coronary heart disease.
Wynn V
J Reprod Med 1991 Mar;36(3 Suppl):219-25. PMID: 2046075

Prognosis

Circulating mir-199-3p screens the onset of type 2 diabetes mellitus and the complication of coronary heart disease and predicts the occurrence of major adverse cardiovascular events.
Ruan R, Liu Y, Zhang X
BMC Cardiovasc Disord 2023 Nov 16;23(1):563. doi: 10.1186/s12872-023-03601-4. PMID: 37974073Free PMC Article
Lipid profile and atherogenic indices in patients with stable chronic obstructive pulmonary disease.
Markelić I, Hlapčić I, Rogić D, Rako I, Samaržija M, Popović-Grle S, Rumora L, Vukić Dugac A
Nutr Metab Cardiovasc Dis 2021 Jan 4;31(1):153-161. Epub 2020 Aug 5 doi: 10.1016/j.numecd.2020.07.039. PMID: 32981798
D-dimer and its Combination with Blood Lipid on Prognosis of Patients with Acute Ischemic Stroke.
Wang J, Feng A, Xu J, Liu Y, Li F, Sun Y, Sun H, Yang F, Zhao J, Tang Y
J Stroke Cerebrovasc Dis 2020 Dec;29(12):105394. Epub 2020 Oct 21 doi: 10.1016/j.jstrokecerebrovasdis.2020.105394. PMID: 33096493
Are high density lipoprotein (HDL) and triglyceride levels relevant in stroke prevention?
Rizos E, Mikhailidis DP
Cardiovasc Res 2001 Nov;52(2):199-207. doi: 10.1016/s0008-6363(01)00383-2. PMID: 11684067
Oral contraceptives and coronary heart disease.
Wynn V
J Reprod Med 1991 Mar;36(3 Suppl):219-25. PMID: 2046075

Clinical prediction guides

D-dimer and its Combination with Blood Lipid on Prognosis of Patients with Acute Ischemic Stroke.
Wang J, Feng A, Xu J, Liu Y, Li F, Sun Y, Sun H, Yang F, Zhao J, Tang Y
J Stroke Cerebrovasc Dis 2020 Dec;29(12):105394. Epub 2020 Oct 21 doi: 10.1016/j.jstrokecerebrovasdis.2020.105394. PMID: 33096493
Evaluation of efficacy and safety of Reteplase and Alteplase in the treatment of hyper-acute cerebral infarction.
Lin ZJ, Qiu HY, Tong XX, Guo Y, Han MF, Yang CS, Lin KH, Wu J, Li X, Yang Y
Biosci Rep 2018 Feb 28;38(1) Epub 2018 Jan 17 doi: 10.1042/BSR20170730. PMID: 29263145Free PMC Article
Vascular inflammation and metabolic activity in hematopoietic organs and liver in familial combined hyperlipidemia and heterozygous familial hypercholesterolemia.
Toutouzas K, Skoumas J, Koutagiar I, Benetos G, Pianou N, Georgakopoulos A, Galanakos S, Antonopoulos A, Drakopoulou M, Oikonomou EK, Kafouris P, Athanasiadis E, Metaxas M, Spyrou G, Pallantza Z, Galiatsatos N, Aggeli C, Antoniades C, Keramida G, Peters AM, Anagnostopoulos CD, Tousoulis D
J Clin Lipidol 2018 Jan-Feb;12(1):33-43. Epub 2017 Nov 2 doi: 10.1016/j.jacl.2017.10.019. PMID: 29174439
Management issues in the metabolic syndrome.
Deedwania PC, Gupta R
J Assoc Physicians India 2006 Oct;54:797-810. PMID: 17214277
Oral contraceptives and coronary heart disease.
Wynn V
J Reprod Med 1991 Mar;36(3 Suppl):219-25. PMID: 2046075

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