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Telaprevir response

MedGen UID:
450486
•Concept ID:
CN078014
•
Sign or Symptom
Synonym: Incivek response
Drug:
Telaprevir
MedGen UID:
406297
•Concept ID:
C1876229
•
Amino Acid, Peptide, or Protein
An orally available peptidomimetic small molecule with activity against hepatitis C virus (HCV). Telaprivir is a selective protease inhibitor that targets the viral HCV NS3-4A serine protease and disrupts processing of viral proteins and formation of a viral replication complex. [from NCI]
Telaprevir
 
Gene (location): IFNL3 (19q13.2)

Definition

PEG-interferon alpha (PEG-IFN 2a and 2b, or PEG-IFN alpha), in combination with ribavirin, is used to treat Hepatitis C Virus (HCV) infection. IFNL3 (also known as IL28B) is a member of the type 3 IFN-alpha family, which are induced by viruses and inhibit HCV replication in vitro. Genetic variants in IFNL3 are associated with increased response (higher sustained virological response rate) to PEG-interferon alpha/ribavirin combination therapy and clearance of HCV. In 2011, the protease inhibitors boceprevir and telaprevir were approved to treat HCV genotype 1 infection in many countries, including the United States and those in the European Union, and are now included in HCV combination therapy. IFNL3 genotype predicts response to this combination therapy and also predicts eligibility for shorter duration of therapy. Guidelines regarding the clinical use of PEG-interferon alpha containing regimens based on IFNL3 genotype have been published in Clinical Pharmacology and Therapeutics by the Clinical Pharmacogenetics Implementation Consortium (CPIC) and are available on the PharmGKB website. [from Clinical Pharmacogenetics Implementation Consortium]

Professional guidelines

PubMed

Cost-effectiveness of boceprevir or telaprevir for untreated patients with genotype 1 chronic hepatitis C.
Cammà C, Petta S, Enea M, Bruno R, Bronte F, Capursi V, Cicchetti A, Colombo GL, Di Marco V, Gasbarrini A, Craxì A; WEF Study Group
Hepatology 2012 Sep;56(3):850-60. Epub 2012 Jul 12 doi: 10.1002/hep.25734. PMID: 22454336

Recent clinical studies

Etiology

New approaches in the treatment of hepatitis C.
González-Grande R, Jiménez-Pérez M, González Arjona C, Mostazo Torres J
World J Gastroenterol 2016 Jan 28;22(4):1421-32. doi: 10.3748/wjg.v22.i4.1421. PMID: 26819511Free PMC Article
Hepatitis C management in post-transplant patients.
Hilgenfeldt E, Firpi RJ
Minerva Gastroenterol Dietol 2015 Mar;61(1):21-9. Epub 2014 Nov 12 PMID: 25390286
Hepatitis C therapy update.
Casey LC, Lee WM
Curr Opin Gastroenterol 2012 May;28(3):188-92. doi: 10.1097/MOG.0b013e3283528e1e. PMID: 22476156
Review and management of drug interactions with boceprevir and telaprevir.
Kiser JJ, Burton JR, Anderson PL, Everson GT
Hepatology 2012 May;55(5):1620-8. doi: 10.1002/hep.25653. PMID: 22331658Free PMC Article
Telaprevir user's guide.
Liapakis AM, Jacobson I
Liver Int 2012 Feb;32 Suppl 1:17-25. doi: 10.1111/j.1478-3231.2011.02708.x. PMID: 22212567

Diagnosis

Diagnostics in hepatitis C: The end of response-guided therapy?
Maasoumy B, Vermehren J
J Hepatol 2016 Oct;65(1 Suppl):S67-S81. doi: 10.1016/j.jhep.2016.07.023. PMID: 27641989
New approaches in the treatment of hepatitis C.
González-Grande R, Jiménez-Pérez M, González Arjona C, Mostazo Torres J
World J Gastroenterol 2016 Jan 28;22(4):1421-32. doi: 10.3748/wjg.v22.i4.1421. PMID: 26819511Free PMC Article
Novel therapeutic approaches for hepatitis C.
Au JS, Pockros PJ
Clin Pharmacol Ther 2014 Jan;95(1):78-88. Epub 2013 Oct 14 doi: 10.1038/clpt.2013.206. PMID: 24126682
Complexities of HCV management in the new era of direct-acting antiviral agents.
Rosenberg WM, Tanwar S, Trembling P
QJM 2014 Jan;107(1):17-9. Epub 2013 Sep 23 doi: 10.1093/qjmed/hct181. PMID: 24065837
Review and management of drug interactions with boceprevir and telaprevir.
Kiser JJ, Burton JR, Anderson PL, Everson GT
Hepatology 2012 May;55(5):1620-8. doi: 10.1002/hep.25653. PMID: 22331658Free PMC Article

Therapy

Hepatitis C management in post-transplant patients.
Hilgenfeldt E, Firpi RJ
Minerva Gastroenterol Dietol 2015 Mar;61(1):21-9. Epub 2014 Nov 12 PMID: 25390286
Novel therapeutic approaches for hepatitis C.
Au JS, Pockros PJ
Clin Pharmacol Ther 2014 Jan;95(1):78-88. Epub 2013 Oct 14 doi: 10.1038/clpt.2013.206. PMID: 24126682
Optimizing treatment in HIV/HCV coinfection.
Puoti M, Rossotti R, Travi G, Panzeri C, Morreale M, Chiari E, Cocca G, Orso M, Moioli MC
Dig Liver Dis 2013 Sep 30;45 Suppl 5:S355-62. doi: 10.1016/j.dld.2013.09.001. PMID: 24091116
Hepatitis C therapy update.
Casey LC, Lee WM
Curr Opin Gastroenterol 2012 May;28(3):188-92. doi: 10.1097/MOG.0b013e3283528e1e. PMID: 22476156
Telaprevir user's guide.
Liapakis AM, Jacobson I
Liver Int 2012 Feb;32 Suppl 1:17-25. doi: 10.1111/j.1478-3231.2011.02708.x. PMID: 22212567

Prognosis

Diagnostics in hepatitis C: The end of response-guided therapy?
Maasoumy B, Vermehren J
J Hepatol 2016 Oct;65(1 Suppl):S67-S81. doi: 10.1016/j.jhep.2016.07.023. PMID: 27641989
Boceprevir and telaprevir for chronic genotype 1 hepatitis C virus infection. A systematic review and meta-analysis.
Manzano-Robleda Mdel C, Ornelas-Arroyo V, Barrientos-Gutiérrez T, Méndez-Sánchez N, Uribe M, Chávez-Tapia NC
Ann Hepatol 2015 Jan-Feb;14(1):46-57. PMID: 25536641
Treatment of hepatitis B and C in children.
El-Shabrawi M, Hassanin F
Minerva Pediatr 2014 Oct;66(5):473-89. PMID: 25253190
Safety of direct antiviral agents in real life.
D'Ambrosio R, Colombo M
Dig Liver Dis 2013 Sep 30;45 Suppl 5:S363-6. doi: 10.1016/j.dld.2013.07.012. PMID: 24091117
Genomics and HCV infection: progression of fibrosis and treatment response.
Estrabaud E, Vidaud M, Marcellin P, Asselah T
J Hepatol 2012 Nov;57(5):1110-25. Epub 2012 May 30 doi: 10.1016/j.jhep.2012.05.016. PMID: 22659520

Clinical prediction guides

Diagnostics in hepatitis C: The end of response-guided therapy?
Maasoumy B, Vermehren J
J Hepatol 2016 Oct;65(1 Suppl):S67-S81. doi: 10.1016/j.jhep.2016.07.023. PMID: 27641989
Boceprevir and telaprevir for chronic genotype 1 hepatitis C virus infection. A systematic review and meta-analysis.
Manzano-Robleda Mdel C, Ornelas-Arroyo V, Barrientos-Gutiérrez T, Méndez-Sánchez N, Uribe M, Chávez-Tapia NC
Ann Hepatol 2015 Jan-Feb;14(1):46-57. PMID: 25536641
Treatment of hepatitis B and C in children.
El-Shabrawi M, Hassanin F
Minerva Pediatr 2014 Oct;66(5):473-89. PMID: 25253190
Telaprevir: clinical pharmacokinetics, pharmacodynamics, and drug-drug interactions.
Kiang TK, Wilby KJ, Ensom MH
Clin Pharmacokinet 2013 Jul;52(7):487-510. doi: 10.1007/s40262-013-0053-x. PMID: 23553423
Genomics and HCV infection: progression of fibrosis and treatment response.
Estrabaud E, Vidaud M, Marcellin P, Asselah T
J Hepatol 2012 Nov;57(5):1110-25. Epub 2012 May 30 doi: 10.1016/j.jhep.2012.05.016. PMID: 22659520

Recent systematic reviews

Interventions for dialysis patients with hepatitis C virus (HCV) infection.
Prabhu AR, Rao IR, Nagaraju SP, Rajwar E, Venkatesh BT, Nair N S, Pai G, Reddy NP, Suvarna D
Cochrane Database Syst Rev 2023 Apr 25;4(4):CD007003. doi: 10.1002/14651858.CD007003.pub3. PMID: 37096802Free PMC Article
Optimisation of triple therapy for patients with chronic hepatitis C: a systematic review.
Pecoraro V, Cariani E, Villa E, Trenti T
Eur J Clin Invest 2016 Aug;46(8):737-48. doi: 10.1111/eci.12656. PMID: 27376688
A network meta-analysis to compare simeprevir with boceprevir and telaprevir in combination with peginterferon-α and ribavirin in patients infected with genotype 1 Hepatitis C virus.
Taieb V, Pacou M, Ho S, Pettré S, Van Sanden S, Pisini M, Ustianowski A, Mehnert A
J Med Econ 2015;18(10):787-96. Epub 2015 May 26 doi: 10.3111/13696998.2015.1046880. PMID: 25934147
Boceprevir and telaprevir for chronic genotype 1 hepatitis C virus infection. A systematic review and meta-analysis.
Manzano-Robleda Mdel C, Ornelas-Arroyo V, Barrientos-Gutiérrez T, Méndez-Sánchez N, Uribe M, Chávez-Tapia NC
Ann Hepatol 2015 Jan-Feb;14(1):46-57. PMID: 25536641
Telaprevir for genotype 1 chronic hepatitis C: a systematic review and meta-analysis.
Gu L, Chen Q, Xie J, Yan Y, Wu G, Tan J, Liang B, Chen W, Wu P, Su L, Tang N
Pharmazie 2012 Dec;67(12):963-72. PMID: 23346756

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