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Tretinoin response

MedGen UID:
450498
•Concept ID:
CN078026
•
Sign or Symptom
Synonyms: All trans retinoic acid response; ATRA response; Retin-A response
Drug:
Tretinoin
MedGen UID:
21254
•Concept ID:
C0040845
•
Pharmacologic Substance
A naturally-occurring acid of retinol. Tretinoin binds to and activates retinoic acid receptors (RARs), thereby inducing changes in gene expression that lead to cell differentiation, decreased cell proliferation, and inhibition of tumorigenesis. This agent also inhibits telomerase, resulting in telomere shortening and eventual apoptosis of some tumor cell types. The oral form of tretinoin has teratogenic and embryotoxic properties. [from NCI]
Tretinoin

Professional guidelines

PubMed

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Curated

DailyMed Drug Label, tretinoin, 2014

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    • GTR
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    • GTR(Clinical)
      Clinical tests in GTR
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