U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Colorectal cancer, non-polyposis

MedGen UID:
808136
•Concept ID:
CN221576
•
Disease or Syndrome

Professional guidelines

PubMed

MYH polyposis syndrome: clinical findings, genetics issues and management.
Sereno M, Merino M, López-Gómez M, Gómez-Raposo C, Zambrana Tébar F, Moreno Rubio J, Espinós J, Martín-Algarra S, Casado Sáenz E
Clin Transl Oncol 2014 Aug;16(8):675-9. Epub 2014 Mar 19 doi: 10.1007/s12094-014-1171-0. PMID: 24643704
Communication and technology in genetic counseling for familial cancer.
Lynch HT, Snyder C, Stacey M, Olson B, Peterson SK, Buxbaum S, Shaw T, Lynch PM
Clin Genet 2014 Mar;85(3):213-22. Epub 2013 Dec 20 doi: 10.1111/cge.12317. PMID: 24355094Free PMC Article
Genetic testing for polyposis: practical and ethical aspects.
Järvinen HJ
Gut 2003 May;52 Suppl 2(Suppl 2):ii19-22. doi: 10.1136/gut.52.suppl_2.ii19. PMID: 12651878Free PMC Article

Recent clinical studies

Etiology

Hereditary colorectal, gastric, and pancreatic cancer: comprehensive review.
Seppälä TT, Burkhart RA, Katona BW
BJS Open 2023 May 5;7(3) doi: 10.1093/bjsopen/zrad023. PMID: 37165697Free PMC Article
Cancer risk and survival in path_MMR carriers by gene and gender up to 75 years of age: a report from the Prospective Lynch Syndrome Database.
Møller P, Seppälä TT, Bernstein I, Holinski-Feder E, Sala P, Gareth Evans D, Lindblom A, Macrae F, Blanco I, Sijmons RH, Jeffries J, Vasen HFA, Burn J, Nakken S, Hovig E, Rødland EA, Tharmaratnam K, de Vos Tot Nederveen Cappel WH, Hill J, Wijnen JT, Jenkins MA, Green K, Lalloo F, Sunde L, Mints M, Bertario L, Pineda M, Navarro M, Morak M, Renkonen-Sinisalo L, Valentin MD, Frayling IM, Plazzer JP, Pylvanainen K, Genuardi M, Mecklin JP, Moeslein G, Sampson JR, Capella G; Mallorca Group
Gut 2018 Jul;67(7):1306-1316. Epub 2017 Jul 28 doi: 10.1136/gutjnl-2017-314057. PMID: 28754778Free PMC Article
Epidemiology, diagnosis, preoperative evaluation and prognostic assessment of upper-tract urothelial carcinoma (UTUC).
Soria F, Shariat SF, Lerner SP, Fritsche HM, Rink M, Kassouf W, Spiess PE, Lotan Y, Ye D, Fernández MI, Kikuchi E, Chade DC, Babjuk M, Grollman AP, Thalmann GN
World J Urol 2017 Mar;35(3):379-387. Epub 2016 Sep 7 doi: 10.1007/s00345-016-1928-x. PMID: 27604375
Update on Hereditary Colorectal Cancer.
DA Silva FC, Wernhoff P, Dominguez-Barrera C, Dominguez-Valentin M
Anticancer Res 2016 Sep;36(9):4399-405. doi: 10.21873/anticanres.10983. PMID: 27630275
Germline MSH6 mutations are more prevalent in endometrial cancer patient cohorts than hereditary non polyposis colorectal cancer cohorts.
Devlin LA, Graham CA, Price JH, Morrison PJ
Ulster Med J 2008 Jan;77(1):25-30. PMID: 18269114Free PMC Article

Diagnosis

Hereditary colorectal, gastric, and pancreatic cancer: comprehensive review.
Seppälä TT, Burkhart RA, Katona BW
BJS Open 2023 May 5;7(3) doi: 10.1093/bjsopen/zrad023. PMID: 37165697Free PMC Article
Epidemiology, diagnosis, preoperative evaluation and prognostic assessment of upper-tract urothelial carcinoma (UTUC).
Soria F, Shariat SF, Lerner SP, Fritsche HM, Rink M, Kassouf W, Spiess PE, Lotan Y, Ye D, Fernández MI, Kikuchi E, Chade DC, Babjuk M, Grollman AP, Thalmann GN
World J Urol 2017 Mar;35(3):379-387. Epub 2016 Sep 7 doi: 10.1007/s00345-016-1928-x. PMID: 27604375
Update on Hereditary Colorectal Cancer.
DA Silva FC, Wernhoff P, Dominguez-Barrera C, Dominguez-Valentin M
Anticancer Res 2016 Sep;36(9):4399-405. doi: 10.21873/anticanres.10983. PMID: 27630275
Screening for uterine tumours.
Van den Bosch T, Coosemans A, Morina M, Timmerman D, Amant F
Best Pract Res Clin Obstet Gynaecol 2012 Apr;26(2):257-66. Epub 2011 Nov 9 doi: 10.1016/j.bpobgyn.2011.08.002. PMID: 22078749
Muir-Torre syndrome.
Ponti G, Ponz de Leon M
Lancet Oncol 2005 Dec;6(12):980-7. doi: 10.1016/S1470-2045(05)70465-4. PMID: 16321766

Therapy

Spontaneous ileostomy closure.
Alyami MS, Lundberg PW, Cotte EG, Glehen OJ
Saudi Med J 2016 Jun;37(6):694-7. doi: 10.15537/Smj.2016.6.14560. PMID: 27279518Free PMC Article
Hereditary cancer syndromes: utilizing DNA repair deficiency as therapeutic target.
Goyal G, Fan T, Silberstein PT
Fam Cancer 2016 Jul;15(3):359-66. doi: 10.1007/s10689-016-9883-7. PMID: 26873719Free PMC Article
Colorectal carcinogenesis--update and perspectives.
Raskov H, Pommergaard HC, Burcharth J, Rosenberg J
World J Gastroenterol 2014 Dec 28;20(48):18151-64. doi: 10.3748/wjg.v20.i48.18151. PMID: 25561783Free PMC Article
Screening for uterine tumours.
Van den Bosch T, Coosemans A, Morina M, Timmerman D, Amant F
Best Pract Res Clin Obstet Gynaecol 2012 Apr;26(2):257-66. Epub 2011 Nov 9 doi: 10.1016/j.bpobgyn.2011.08.002. PMID: 22078749
Lynch syndrome (hereditary non-polyposis colorectal cancer): current concepts and approaches to management.
Ricciardiello L, Boland CR
Curr Gastroenterol Rep 2005 Oct;7(5):412-20. doi: 10.1007/s11894-005-0012-2. PMID: 16168241

Prognosis

Cancer risk and survival in path_MMR carriers by gene and gender up to 75 years of age: a report from the Prospective Lynch Syndrome Database.
Møller P, Seppälä TT, Bernstein I, Holinski-Feder E, Sala P, Gareth Evans D, Lindblom A, Macrae F, Blanco I, Sijmons RH, Jeffries J, Vasen HFA, Burn J, Nakken S, Hovig E, Rødland EA, Tharmaratnam K, de Vos Tot Nederveen Cappel WH, Hill J, Wijnen JT, Jenkins MA, Green K, Lalloo F, Sunde L, Mints M, Bertario L, Pineda M, Navarro M, Morak M, Renkonen-Sinisalo L, Valentin MD, Frayling IM, Plazzer JP, Pylvanainen K, Genuardi M, Mecklin JP, Moeslein G, Sampson JR, Capella G; Mallorca Group
Gut 2018 Jul;67(7):1306-1316. Epub 2017 Jul 28 doi: 10.1136/gutjnl-2017-314057. PMID: 28754778Free PMC Article
Epidemiology, diagnosis, preoperative evaluation and prognostic assessment of upper-tract urothelial carcinoma (UTUC).
Soria F, Shariat SF, Lerner SP, Fritsche HM, Rink M, Kassouf W, Spiess PE, Lotan Y, Ye D, Fernández MI, Kikuchi E, Chade DC, Babjuk M, Grollman AP, Thalmann GN
World J Urol 2017 Mar;35(3):379-387. Epub 2016 Sep 7 doi: 10.1007/s00345-016-1928-x. PMID: 27604375
Hereditary ovarian cancer.
Russo A, Calò V, Bruno L, Rizzo S, Bazan V, Di Fede G
Crit Rev Oncol Hematol 2009 Jan;69(1):28-44. Epub 2008 Jul 24 doi: 10.1016/j.critrevonc.2008.06.003. PMID: 18656380
Muir-Torre syndrome.
Ponti G, Ponz de Leon M
Lancet Oncol 2005 Dec;6(12):980-7. doi: 10.1016/S1470-2045(05)70465-4. PMID: 16321766
Hereditary non-polyposis colorectal cancer.
Green SE, Bradburn DM, Varma JS, Burn J
Int J Colorectal Dis 1998;13(1):3-12. doi: 10.1007/s003840050123. PMID: 9548093

Clinical prediction guides

Mismatch repair system in colorectal cancer. Frequency, cancer phenotype, and follow-up.
Rios-Valencia J, Cruz-Reyes C, Galindo-García TA, Rosas-Camargo V, Gamboa-Domínguez A
Rev Gastroenterol Mex (Engl Ed) 2022 Oct-Dec;87(4):432-438. Epub 2022 Jun 2 doi: 10.1016/j.rgmxen.2022.05.017. PMID: 35661637
Cancer risk and survival in path_MMR carriers by gene and gender up to 75 years of age: a report from the Prospective Lynch Syndrome Database.
Møller P, Seppälä TT, Bernstein I, Holinski-Feder E, Sala P, Gareth Evans D, Lindblom A, Macrae F, Blanco I, Sijmons RH, Jeffries J, Vasen HFA, Burn J, Nakken S, Hovig E, Rødland EA, Tharmaratnam K, de Vos Tot Nederveen Cappel WH, Hill J, Wijnen JT, Jenkins MA, Green K, Lalloo F, Sunde L, Mints M, Bertario L, Pineda M, Navarro M, Morak M, Renkonen-Sinisalo L, Valentin MD, Frayling IM, Plazzer JP, Pylvanainen K, Genuardi M, Mecklin JP, Moeslein G, Sampson JR, Capella G; Mallorca Group
Gut 2018 Jul;67(7):1306-1316. Epub 2017 Jul 28 doi: 10.1136/gutjnl-2017-314057. PMID: 28754778Free PMC Article
Epidemiology, diagnosis, preoperative evaluation and prognostic assessment of upper-tract urothelial carcinoma (UTUC).
Soria F, Shariat SF, Lerner SP, Fritsche HM, Rink M, Kassouf W, Spiess PE, Lotan Y, Ye D, Fernández MI, Kikuchi E, Chade DC, Babjuk M, Grollman AP, Thalmann GN
World J Urol 2017 Mar;35(3):379-387. Epub 2016 Sep 7 doi: 10.1007/s00345-016-1928-x. PMID: 27604375
Synchronous colorectal cancer: clinical, pathological and molecular implications.
Lam AK, Chan SS, Leung M
World J Gastroenterol 2014 Jun 14;20(22):6815-20. doi: 10.3748/wjg.v20.i22.6815. PMID: 24944471Free PMC Article
Hereditary non-polyposis colorectal cancer.
Green SE, Bradburn DM, Varma JS, Burn J
Int J Colorectal Dis 1998;13(1):3-12. doi: 10.1007/s003840050123. PMID: 9548093

Recent systematic reviews

Complications and functional outcomes after ileo-anal pouch excision-a systematic review of 14 retrospective observational studies.
MacDonald S, Au S, Thornton M, Macdonald A
Int J Colorectal Dis 2021 Apr;36(4):677-687. Epub 2021 Jan 20 doi: 10.1007/s00384-021-03838-5. PMID: 33471205
Synchronous Endometrial and Ovarian Cancer in Young Women: Case Report and Review of the Literature.
Dogan A, Schultheis B, Rezniczek GA, Hilal Z, Cetin C, Häusler G, Tempfer CB
Anticancer Res 2017 Mar;37(3):969-978. doi: 10.21873/anticanres.11406. PMID: 28314254
Epidemiology, diagnosis, preoperative evaluation and prognostic assessment of upper-tract urothelial carcinoma (UTUC).
Soria F, Shariat SF, Lerner SP, Fritsche HM, Rink M, Kassouf W, Spiess PE, Lotan Y, Ye D, Fernández MI, Kikuchi E, Chade DC, Babjuk M, Grollman AP, Thalmann GN
World J Urol 2017 Mar;35(3):379-387. Epub 2016 Sep 7 doi: 10.1007/s00345-016-1928-x. PMID: 27604375
Chemoprevention of colorectal cancer: systematic review and economic evaluation.
Cooper K, Squires H, Carroll C, Papaioannou D, Booth A, Logan RF, Maguire C, Hind D, Tappenden P
Health Technol Assess 2010 Jun;14(32):1-206. doi: 10.3310/hta14320. PMID: 20594533
Recommendations for the care of individuals with an inherited predisposition to Lynch syndrome: a systematic review.
Lindor NM, Petersen GM, Hadley DW, Kinney AY, Miesfeldt S, Lu KH, Lynch P, Burke W, Press N
JAMA 2006 Sep 27;296(12):1507-17. doi: 10.1001/jama.296.12.1507. PMID: 17003399

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Reviews

    Related information

    • ClinVar
      Related medical variations
    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...