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Mild obesity

MedGen UID:
832924
•Concept ID:
CN228310
•
Finding

Professional guidelines

PubMed

Assessment of Risk Factors Associated with Cardiovascular Diseases in Overweight Women.
Castro MJ, Jiménez JM, López M, Cao MJ, Durán M, Albertos I, García S, Ruiz-Tovar J
Nutrients 2021 Oct 19;13(10) doi: 10.3390/nu13103658. PMID: 34684659Free PMC Article
Children with Severe Obesity in Family-Based Obesity Treatment Compared with Other Participants: Conclusions Depend on Metrics.
Hayes JF, Fowler LA, Balantekin KN, Saelens BE, Stein RI, Perri MG, Welch RR, Epstein LH, Wilfley DE
Obesity (Silver Spring) 2021 Feb;29(2):393-401. doi: 10.1002/oby.23071. PMID: 33491306Free PMC Article
Dietary weight-loss interventions for the management of obesity in older adults.
Goisser S, Kiesswetter E, Schoene D, Torbahn G, Bauer JM
Rev Endocr Metab Disord 2020 Sep;21(3):355-368. doi: 10.1007/s11154-020-09577-2. PMID: 32829454

Recent clinical studies

Etiology

Childhood adiposity and novel subtypes of diabetes in adults: a Mendelian randomisation and genome-wide genetic correlation study.
Wei Y, Zhan Y, Carlsson S
Lancet Glob Health 2023 Mar;11 Suppl 1:S1. doi: 10.1016/S2214-109X(23)00086-4. PMID: 36866468
A novel diabetes typology: towards precision diabetology from pathogenesis to treatment.
Herder C, Roden M
Diabetologia 2022 Nov;65(11):1770-1781. Epub 2022 Jan 4 doi: 10.1007/s00125-021-05625-x. PMID: 34981134Free PMC Article
Genome-wide association analyses highlight etiological differences underlying newly defined subtypes of diabetes.
Mansour Aly D, Dwivedi OP, Prasad RB, Käräjämäki A, Hjort R, Thangam M, Åkerlund M, Mahajan A, Udler MS, Florez JC, McCarthy MI; Regeneron Genetics Center, Brosnan J, Melander O, Carlsson S, Hansson O, Tuomi T, Groop L, Ahlqvist E
Nat Genet 2021 Nov;53(11):1534-1542. Epub 2021 Nov 4 doi: 10.1038/s41588-021-00948-2. PMID: 34737425
Cardiovascular morbidity, diabetes and cancer risk among children and adolescents with severe obesity.
Bendor CD, Bardugo A, Pinhas-Hamiel O, Afek A, Twig G
Cardiovasc Diabetol 2020 Jun 13;19(1):79. doi: 10.1186/s12933-020-01052-1. PMID: 32534575Free PMC Article
The effects of body mass index on lung volumes.
Jones RL, Nzekwu MM
Chest 2006 Sep;130(3):827-33. doi: 10.1378/chest.130.3.827. PMID: 16963682

Diagnosis

Impact of childhood growth and obesity curves in school health examinations.
Takaya J, Higashino H, Takaya R, Sakaguchi H, Tanoue J, Higashide T, Moriguchi H, Nakao M, Shigematsu S
Pediatr Int 2022 Jan;64(1):e15182. doi: 10.1111/ped.15182. PMID: 35522831
Cardiovascular morbidity, diabetes and cancer risk among children and adolescents with severe obesity.
Bendor CD, Bardugo A, Pinhas-Hamiel O, Afek A, Twig G
Cardiovasc Diabetol 2020 Jun 13;19(1):79. doi: 10.1186/s12933-020-01052-1. PMID: 32534575Free PMC Article
Adolescent Obesity and Early-Onset Type 2 Diabetes.
Twig G, Zucker I, Afek A, Cukierman-Yaffe T, Bendor CD, Derazne E, Lutski M, Shohat T, Mosenzon O, Tzur D, Pinhas-Hamiel O, Tiosano S, Raz I, Gerstein HC, Tirosh A
Diabetes Care 2020 Jul;43(7):1487-1495. Epub 2020 Apr 22 doi: 10.2337/dc19-1988. PMID: 32321731
Risk of diabetes-associated diseases in subgroups of patients with recent-onset diabetes: a 5-year follow-up study.
Zaharia OP, Strassburger K, Strom A, Bönhof GJ, Karusheva Y, Antoniou S, Bódis K, Markgraf DF, Burkart V, Müssig K, Hwang JH, Asplund O, Groop L, Ahlqvist E, Seissler J, Nawroth P, Kopf S, Schmid SM, Stumvoll M, Pfeiffer AFH, Kabisch S, Tselmin S, Häring HU, Ziegler D, Kuss O, Szendroedi J, Roden M; German Diabetes Study Group
Lancet Diabetes Endocrinol 2019 Sep;7(9):684-694. Epub 2019 Jul 22 doi: 10.1016/S2213-8587(19)30187-1. PMID: 31345776
Obesity and cardiovascular diseases: implications regarding fitness, fatness, and severity in the obesity paradox.
Lavie CJ, McAuley PA, Church TS, Milani RV, Blair SN
J Am Coll Cardiol 2014 Apr 15;63(14):1345-54. Epub 2014 Feb 12 doi: 10.1016/j.jacc.2014.01.022. PMID: 24530666

Therapy

Mild obesity does not affect perinatal outcome in gestational carrier cycles.
Clain E, Kaizer LK, Sammel MD, Wang J, Homer M, Uhler M, Hoyos LR, Devine K, Polotsky AJ
Hum Reprod 2024 Jun 3;39(6):1316-1322. doi: 10.1093/humrep/deae079. PMID: 38636947
Childhood adiposity and novel subtypes of diabetes in adults: a Mendelian randomisation and genome-wide genetic correlation study.
Wei Y, Zhan Y, Carlsson S
Lancet Glob Health 2023 Mar;11 Suppl 1:S1. doi: 10.1016/S2214-109X(23)00086-4. PMID: 36866468
Childhood adiposity and novel subtypes of adult-onset diabetes: a Mendelian randomisation and genome-wide genetic correlation study.
Wei Y, Richardson TG, Zhan Y, Carlsson S
Diabetologia 2023 Jun;66(6):1052-1056. Epub 2023 Feb 27 doi: 10.1007/s00125-023-05883-x. PMID: 36843089Free PMC Article
Altered blood gene expression in the obesity-related type 2 diabetes cluster may be causally involved in lipid metabolism: a Mendelian randomisation study.
de Klerk JA, Beulens JWJ, Mei H, Bijkerk R, van Zonneveld AJ, Koivula RW, Elders PJM, 't Hart LM, Slieker RC
Diabetologia 2023 Jun;66(6):1057-1070. Epub 2023 Feb 24 doi: 10.1007/s00125-023-05886-8. PMID: 36826505Free PMC Article
Roux-En-Y Gastric Bypass in Type 2 Diabetes Patients with Mild Obesity: a Systematic Review and Meta-analysis.
Cohen R, Le Roux CW, Junqueira S, Ribeiro RA, Luque A
Obes Surg 2017 Oct;27(10):2733-2739. doi: 10.1007/s11695-017-2869-1. PMID: 28785975

Prognosis

Novel metabolic classification for extrahepatic complication of metabolic associated fatty liver disease: A data-driven cluster analysis with international validation.
Ye J, Zhuang X, Li X, Gong X, Sun Y, Wang W, Feng S, Wu T, Zhong B
Metabolism 2022 Nov;136:155294. Epub 2022 Aug 20 doi: 10.1016/j.metabol.2022.155294. PMID: 35995280
A novel diabetes typology: towards precision diabetology from pathogenesis to treatment.
Herder C, Roden M
Diabetologia 2022 Nov;65(11):1770-1781. Epub 2022 Jan 4 doi: 10.1007/s00125-021-05625-x. PMID: 34981134Free PMC Article
Cardiovascular morbidity, diabetes and cancer risk among children and adolescents with severe obesity.
Bendor CD, Bardugo A, Pinhas-Hamiel O, Afek A, Twig G
Cardiovasc Diabetol 2020 Jun 13;19(1):79. doi: 10.1186/s12933-020-01052-1. PMID: 32534575Free PMC Article
Risk of diabetes-associated diseases in subgroups of patients with recent-onset diabetes: a 5-year follow-up study.
Zaharia OP, Strassburger K, Strom A, Bönhof GJ, Karusheva Y, Antoniou S, Bódis K, Markgraf DF, Burkart V, Müssig K, Hwang JH, Asplund O, Groop L, Ahlqvist E, Seissler J, Nawroth P, Kopf S, Schmid SM, Stumvoll M, Pfeiffer AFH, Kabisch S, Tselmin S, Häring HU, Ziegler D, Kuss O, Szendroedi J, Roden M; German Diabetes Study Group
Lancet Diabetes Endocrinol 2019 Sep;7(9):684-694. Epub 2019 Jul 22 doi: 10.1016/S2213-8587(19)30187-1. PMID: 31345776
Obesity and cardiovascular diseases: implications regarding fitness, fatness, and severity in the obesity paradox.
Lavie CJ, McAuley PA, Church TS, Milani RV, Blair SN
J Am Coll Cardiol 2014 Apr 15;63(14):1345-54. Epub 2014 Feb 12 doi: 10.1016/j.jacc.2014.01.022. PMID: 24530666

Clinical prediction guides

Childhood adiposity and novel subtypes of diabetes in adults: a Mendelian randomisation and genome-wide genetic correlation study.
Wei Y, Zhan Y, Carlsson S
Lancet Glob Health 2023 Mar;11 Suppl 1:S1. doi: 10.1016/S2214-109X(23)00086-4. PMID: 36866468
Epidemiological Review of Gastroesophageal Junction Adenocarcinoma in Asian Countries.
Manabe N, Matsueda K, Haruma K
Digestion 2022;103(1):29-36. Epub 2021 Oct 29 doi: 10.1159/000519602. PMID: 34718236
Genome-wide association analyses highlight etiological differences underlying newly defined subtypes of diabetes.
Mansour Aly D, Dwivedi OP, Prasad RB, Käräjämäki A, Hjort R, Thangam M, Åkerlund M, Mahajan A, Udler MS, Florez JC, McCarthy MI; Regeneron Genetics Center, Brosnan J, Melander O, Carlsson S, Hansson O, Tuomi T, Groop L, Ahlqvist E
Nat Genet 2021 Nov;53(11):1534-1542. Epub 2021 Nov 4 doi: 10.1038/s41588-021-00948-2. PMID: 34737425
Mild obesity does not affect the forearm muscle microvascular responses to hyperglycemia.
Soares RN, Reimer RA, Doyle-Baker PK, Murias JM
Microcirculation 2021 Feb;28(2):e12669. Epub 2020 Nov 21 doi: 10.1111/micc.12669. PMID: 33150675
Risk of diabetes-associated diseases in subgroups of patients with recent-onset diabetes: a 5-year follow-up study.
Zaharia OP, Strassburger K, Strom A, Bönhof GJ, Karusheva Y, Antoniou S, Bódis K, Markgraf DF, Burkart V, Müssig K, Hwang JH, Asplund O, Groop L, Ahlqvist E, Seissler J, Nawroth P, Kopf S, Schmid SM, Stumvoll M, Pfeiffer AFH, Kabisch S, Tselmin S, Häring HU, Ziegler D, Kuss O, Szendroedi J, Roden M; German Diabetes Study Group
Lancet Diabetes Endocrinol 2019 Sep;7(9):684-694. Epub 2019 Jul 22 doi: 10.1016/S2213-8587(19)30187-1. PMID: 31345776

Recent systematic reviews

Obesity Paradox in the Intrahospital and Follow-Up Phases of the Acute Coronary Syndrome: A Meta-Analysis and Systematic Review.
Mornar Jelavic M, Babic Z, Pintaric H
Cardiology 2023;148(6):528-544. Epub 2023 Aug 8 doi: 10.1159/000531985. PMID: 37552961
Diabetes remission of bariatric surgery and nonsurgical treatments in type 2 diabetes patients who failure to meet the criteria for surgery: a systematic review and meta-analysis.
Zhou X, Zeng C
BMC Endocr Disord 2023 Feb 22;23(1):46. doi: 10.1186/s12902-023-01283-9. PMID: 36810013Free PMC Article
Cardiovascular morbidity, diabetes and cancer risk among children and adolescents with severe obesity.
Bendor CD, Bardugo A, Pinhas-Hamiel O, Afek A, Twig G
Cardiovasc Diabetol 2020 Jun 13;19(1):79. doi: 10.1186/s12933-020-01052-1. PMID: 32534575Free PMC Article
Roux-En-Y Gastric Bypass in Type 2 Diabetes Patients with Mild Obesity: a Systematic Review and Meta-analysis.
Cohen R, Le Roux CW, Junqueira S, Ribeiro RA, Luque A
Obes Surg 2017 Oct;27(10):2733-2739. doi: 10.1007/s11695-017-2869-1. PMID: 28785975
Systematic review of laparoscopic adjustable gastric banding in patients with body mass index ≤35 kg/m².
Adegbola S, Tayeh S, Agrawal S
Surg Obes Relat Dis 2014 Jan-Feb;10(1):155-60. Epub 2013 Jun 2 doi: 10.1016/j.soard.2013.05.005. PMID: 23932006

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