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atorvastatin response - Efficacy

MedGen UID:
1001907
•Concept ID:
CN322724
•
Sign or Symptom

Professional guidelines

PubMed

Association between CYP3A4/CYP3A5 genetic polymorphisms and treatment outcomes of atorvastatin worldwide: is there enough research on the Egyptian population?
Maslub MG, Radwan MA, Daud NAA, Sha'aban A
Eur J Med Res 2023 Sep 27;28(1):381. doi: 10.1186/s40001-023-01038-1. PMID: 37759317Free PMC Article
Associations between statins and adverse events in primary prevention of cardiovascular disease: systematic review with pairwise, network, and dose-response meta-analyses.
Cai T, Abel L, Langford O, Monaghan G, Aronson JK, Stevens RJ, Lay-Flurrie S, Koshiaris C, McManus RJ, Hobbs FDR, Sheppard JP
BMJ 2021 Jul 14;374:n1537. doi: 10.1136/bmj.n1537. PMID: 34261627Free PMC Article
Real-life management of drug-drug interactions between antiretrovirals and statins.
Courlet P, Livio F, Alves Saldanha S, Scherrer A, Battegay M, Cavassini M, Stoeckle M, Decosterd LA, Marzolini C; Swiss HIV Cohort Study
J Antimicrob Chemother 2020 Jul 1;75(7):1972-1980. doi: 10.1093/jac/dkaa099. PMID: 32240298

Recent clinical studies

Etiology

Pravastatin for lowering lipids.
Adams SP, Alaeiilkhchi N, Tasnim S, Wright JM
Cochrane Database Syst Rev 2023 Sep 18;9(9):CD013673. doi: 10.1002/14651858.CD013673.pub2. PMID: 37721222Free PMC Article
Associations between statins and adverse events in primary prevention of cardiovascular disease: systematic review with pairwise, network, and dose-response meta-analyses.
Cai T, Abel L, Langford O, Monaghan G, Aronson JK, Stevens RJ, Lay-Flurrie S, Koshiaris C, McManus RJ, Hobbs FDR, Sheppard JP
BMJ 2021 Jul 14;374:n1537. doi: 10.1136/bmj.n1537. PMID: 34261627Free PMC Article
Ezetimibe: a review of its metabolism, pharmacokinetics and drug interactions.
Kosoglou T, Statkevich P, Johnson-Levonas AO, Paolini JF, Bergman AJ, Alton KB
Clin Pharmacokinet 2005;44(5):467-94. doi: 10.2165/00003088-200544050-00002. PMID: 15871634
Intensive lipid lowering with atorvastatin in patients with stable coronary disease.
LaRosa JC, Grundy SM, Waters DD, Shear C, Barter P, Fruchart JC, Gotto AM, Greten H, Kastelein JJ, Shepherd J, Wenger NK; Treating to New Targets (TNT) Investigators
N Engl J Med 2005 Apr 7;352(14):1425-35. Epub 2005 Mar 8 doi: 10.1056/NEJMoa050461. PMID: 15755765
Comparison of the efficacy and safety of rosuvastatin versus atorvastatin, simvastatin, and pravastatin across doses (STELLAR* Trial).
Jones PH, Davidson MH, Stein EA, Bays HE, McKenney JM, Miller E, Cain VA, Blasetto JW; STELLAR Study Group
Am J Cardiol 2003 Jul 15;92(2):152-60. doi: 10.1016/s0002-9149(03)00530-7. PMID: 12860216

Diagnosis

Statins and thyroid eye disease (TED): a systematic review.
Malboosbaf R, Maghsoomi Z, Emami Z, Khamseh ME, Azizi F
Endocrine 2024 Jul;85(1):11-17. Epub 2024 Jan 9 doi: 10.1007/s12020-023-03680-5. PMID: 38194219
Machine-learning-based analysis of the sensitivity and specificity on lipid-lowering effect of one-month-administered statins.
Liu H, Jiao R, Wang L, Feng F, Zhao X, Yang J
Medicine (Baltimore) 2023 Mar 3;102(9):e33139. doi: 10.1097/MD.0000000000033139. PMID: 36862920Free PMC Article
No association between LDL receptor and CETP genetic variants and atorvastatin response in Jordanian hyperlipidemic patients.
Zihlif M, Otoum S, Al Shhab M, Almadani Z, Momani M, Alhawari H, Esraa Jibrini, Jarrar Y, Al-Ameer H, Imraish A
Drug Metab Pers Ther 2022 Dec 1;37(4):369-374. Epub 2022 Apr 21 doi: 10.1515/dmpt-2021-0177. PMID: 35447021
Efficacy and safety of rosuvastatin versus atorvastatin in high-risk Chinese patients with hypercholesterolemia: a randomized, double-blind, active-controlled study.
Zhao S, Peng D
Curr Med Res Opin 2018 Feb;34(2):227-235. Epub 2017 Sep 18 doi: 10.1080/03007995.2017.1371584. PMID: 28836458
Experimental therapies in hypertrophic cardiomyopathy.
Marian AJ
J Cardiovasc Transl Res 2009 Dec;2(4):483-92. Epub 2009 Oct 1 doi: 10.1007/s12265-009-9132-7. PMID: 20560006Free PMC Article

Therapy

Pravastatin for lowering lipids.
Adams SP, Alaeiilkhchi N, Tasnim S, Wright JM
Cochrane Database Syst Rev 2023 Sep 18;9(9):CD013673. doi: 10.1002/14651858.CD013673.pub2. PMID: 37721222Free PMC Article
Associations between statins and adverse events in primary prevention of cardiovascular disease: systematic review with pairwise, network, and dose-response meta-analyses.
Cai T, Abel L, Langford O, Monaghan G, Aronson JK, Stevens RJ, Lay-Flurrie S, Koshiaris C, McManus RJ, Hobbs FDR, Sheppard JP
BMJ 2021 Jul 14;374:n1537. doi: 10.1136/bmj.n1537. PMID: 34261627Free PMC Article
Fluvastatin for lowering lipids.
Adams SP, Sekhon SS, Tsang M, Wright JM
Cochrane Database Syst Rev 2018 Mar 6;3(3):CD012282. doi: 10.1002/14651858.CD012282.pub2. PMID: 29508377Free PMC Article
Intensive lipid lowering with atorvastatin in patients with stable coronary disease.
LaRosa JC, Grundy SM, Waters DD, Shear C, Barter P, Fruchart JC, Gotto AM, Greten H, Kastelein JJ, Shepherd J, Wenger NK; Treating to New Targets (TNT) Investigators
N Engl J Med 2005 Apr 7;352(14):1425-35. Epub 2005 Mar 8 doi: 10.1056/NEJMoa050461. PMID: 15755765
Comparison of the efficacy and safety of rosuvastatin versus atorvastatin, simvastatin, and pravastatin across doses (STELLAR* Trial).
Jones PH, Davidson MH, Stein EA, Bays HE, McKenney JM, Miller E, Cain VA, Blasetto JW; STELLAR Study Group
Am J Cardiol 2003 Jul 15;92(2):152-60. doi: 10.1016/s0002-9149(03)00530-7. PMID: 12860216

Prognosis

Autonomous circadian rhythms in the human hepatocyte regulate hepatic drug metabolism and inflammatory responses.
March S, Nerurkar N, Jain A, Andrus L, Kim D, Whittaker CA, Tan EKW, Thiberge S, Fleming HE, Mancio-Silva L, Rice CM, Bhatia SN
Sci Adv 2024 Apr 26;10(17):eadm9281. Epub 2024 Apr 24 doi: 10.1126/sciadv.adm9281. PMID: 38657074Free PMC Article
Statins in Graves Orbitopathy: A New Therapeutic Tool.
Lanzolla G, Comi S, Cosentino G, Pakdel F, Marinò M
Ophthalmic Plast Reconstr Surg 2023 Dec 1;39(6S):S29-S39. Epub 2023 Dec 4 doi: 10.1097/IOP.0000000000002525. PMID: 38054983
Machine-learning-based analysis of the sensitivity and specificity on lipid-lowering effect of one-month-administered statins.
Liu H, Jiao R, Wang L, Feng F, Zhao X, Yang J
Medicine (Baltimore) 2023 Mar 3;102(9):e33139. doi: 10.1097/MD.0000000000033139. PMID: 36862920Free PMC Article
SLCO1B1 and ABCB1 variants synergistically influence the atorvastatin treatment response in South Indian coronary artery disease patients.
Bharath G, Vishnuprabu DP, Preethi L, Nagappan AS, Dhianeshwaran Isravanya RT, Bhaskar LV, Swaminathan N, Munirajan AK
Pharmacogenomics 2022 Aug;23(12):683-694. Epub 2022 Aug 15 doi: 10.2217/pgs-2022-0044. PMID: 35968761
Intensive lipid lowering with atorvastatin in patients with stable coronary disease.
LaRosa JC, Grundy SM, Waters DD, Shear C, Barter P, Fruchart JC, Gotto AM, Greten H, Kastelein JJ, Shepherd J, Wenger NK; Treating to New Targets (TNT) Investigators
N Engl J Med 2005 Apr 7;352(14):1425-35. Epub 2005 Mar 8 doi: 10.1056/NEJMoa050461. PMID: 15755765

Clinical prediction guides

Tumor-targeting hydroxyapatite nanoparticles for remodeling tumor immune microenvironment (TIME) by activating mitoDNA-pyroptosis pathway in cancer.
Yang Y, Yang J, Zhu N, Qiu H, Feng W, Chen Y, Chen X, Chen Y, Zheng W, Liang M, Lin T, Yu J, Guo Z
J Nanobiotechnology 2023 Dec 7;21(1):470. doi: 10.1186/s12951-023-02231-4. PMID: 38062467Free PMC Article
SLCO1B1 and ABCB1 variants synergistically influence the atorvastatin treatment response in South Indian coronary artery disease patients.
Bharath G, Vishnuprabu DP, Preethi L, Nagappan AS, Dhianeshwaran Isravanya RT, Bhaskar LV, Swaminathan N, Munirajan AK
Pharmacogenomics 2022 Aug;23(12):683-694. Epub 2022 Aug 15 doi: 10.2217/pgs-2022-0044. PMID: 35968761
Comparative efficacy between atorvastatin and rosuvastatin in the prevention of cardiovascular disease recurrence.
Perez-Calahorra S, Laclaustra M, Marco-Benedi V, Pinto X, Sanchez-Hernandez RM, Plana N, Ortega E, Fuentes F, Civeira F
Lipids Health Dis 2019 Dec 11;18(1):216. doi: 10.1186/s12944-019-1153-x. PMID: 31829197Free PMC Article
Influence of SLCO1B1 polymorphisms on atorvastatin efficacy and safety in Macedonian subjects.
Mladenovska K, Grapci AD, Vavlukis M, Kapedanovska A, Eftimov A, Geshkovska NM, Nebija D, Dimovski AJ
Pharmazie 2017 May 1;72(5):288-295. doi: 10.1801/ph.2017.6960. PMID: 29441875
Ezetimibe: a review of its metabolism, pharmacokinetics and drug interactions.
Kosoglou T, Statkevich P, Johnson-Levonas AO, Paolini JF, Bergman AJ, Alton KB
Clin Pharmacokinet 2005;44(5):467-94. doi: 10.2165/00003088-200544050-00002. PMID: 15871634

Recent systematic reviews

Pravastatin for lowering lipids.
Adams SP, Alaeiilkhchi N, Tasnim S, Wright JM
Cochrane Database Syst Rev 2023 Sep 18;9(9):CD013673. doi: 10.1002/14651858.CD013673.pub2. PMID: 37721222Free PMC Article
Associations between statins and adverse events in primary prevention of cardiovascular disease: systematic review with pairwise, network, and dose-response meta-analyses.
Cai T, Abel L, Langford O, Monaghan G, Aronson JK, Stevens RJ, Lay-Flurrie S, Koshiaris C, McManus RJ, Hobbs FDR, Sheppard JP
BMJ 2021 Jul 14;374:n1537. doi: 10.1136/bmj.n1537. PMID: 34261627Free PMC Article
Fluvastatin for lowering lipids.
Adams SP, Sekhon SS, Tsang M, Wright JM
Cochrane Database Syst Rev 2018 Mar 6;3(3):CD012282. doi: 10.1002/14651858.CD012282.pub2. PMID: 29508377Free PMC Article
Lipid-lowering efficacy of atorvastatin.
Adams SP, Tsang M, Wright JM
Cochrane Database Syst Rev 2015 Mar 12;2015(3):CD008226. doi: 10.1002/14651858.CD008226.pub3. PMID: 25760954Free PMC Article
Lipid-lowering efficacy of rosuvastatin.
Adams SP, Sekhon SS, Wright JM
Cochrane Database Syst Rev 2014 Nov 21;2014(11):CD010254. doi: 10.1002/14651858.CD010254.pub2. PMID: 25415541Free PMC Article

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