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clopidogrel response - Efficacy

MedGen UID:
1002723
•Concept ID:
CN322727
•
Sign or Symptom

Professional guidelines

PubMed

Pharmacogenomics for Primary Care: An Overview.
Rollinson V, Turner R, Pirmohamed M
Genes (Basel) 2020 Nov 12;11(11) doi: 10.3390/genes11111337. PMID: 33198260Free PMC Article
Genotype-based clinical trials in cardiovascular disease.
Pereira NL, Sargent DJ, Farkouh ME, Rihal CS
Nat Rev Cardiol 2015 Aug;12(8):475-87. Epub 2015 May 5 doi: 10.1038/nrcardio.2015.64. PMID: 25940926Free PMC Article
Genetics of platelet inhibitor treatment.
Trenk D, Hochholzer W
Br J Clin Pharmacol 2014 Apr;77(4):642-53. doi: 10.1111/bcp.12230. PMID: 23981082Free PMC Article

Recent clinical studies

Etiology

Do patients benefit from omega-3 fatty acids?
Sherratt SCR, Mason RP, Libby P, Steg PG, Bhatt DL
Cardiovasc Res 2024 Feb 17;119(18):2884-2901. doi: 10.1093/cvr/cvad188. PMID: 38252923Free PMC Article
Safety and efficacy of factor XIa inhibition with milvexian for secondary stroke prevention (AXIOMATIC-SSP): a phase 2, international, randomised, double-blind, placebo-controlled, dose-finding trial.
Sharma M, Molina CA, Toyoda K, Bereczki D, Bangdiwala SI, Kasner SE, Lutsep HL, Tsivgoulis G, Ntaios G, Czlonkowska A, Shuaib A, Amarenco P, Endres M, Yoon BW, Tanne D, Toni D, Yperzeele L, von Weitzel-Mudersbach P, Sampaio Silva G, Avezum A, Dawson J, Strbian D, Tatlisumak T, Eckstein J, Ameriso SF, Weber JR, Sandset EC, Goar Pogosova N, Lavados PM, Arauz A, Gailani D, Diener HC, Bernstein RA, Cordonnier C, Kahl A, Abelian G, Donovan M, Pachai C, Li D, Hankey GJ
Lancet Neurol 2024 Jan;23(1):46-59. doi: 10.1016/S1474-4422(23)00403-9. PMID: 38101902Free PMC Article
Pharmacogenetics in Cardiovascular Medicine.
Weeke PE
Adv Pharmacol 2018;83:333-360. doi: 10.1016/bs.apha.2018.04.002. PMID: 29801582
Use of clopidogrel with or without aspirin in patients taking oral anticoagulant therapy and undergoing percutaneous coronary intervention: an open-label, randomised, controlled trial.
Dewilde WJ, Oirbans T, Verheugt FW, Kelder JC, De Smet BJ, Herrman JP, Adriaenssens T, Vrolix M, Heestermans AA, Vis MM, Tijsen JG, van 't Hof AW, ten Berg JM; WOEST study investigators
Lancet 2013 Mar 30;381(9872):1107-15. Epub 2013 Feb 13 doi: 10.1016/S0140-6736(12)62177-1. PMID: 23415013
Comparison of ticagrelor, the first reversible oral P2Y(12) receptor antagonist, with clopidogrel in patients with acute coronary syndromes: Rationale, design, and baseline characteristics of the PLATelet inhibition and patient Outcomes (PLATO) trial.
James S, Akerblom A, Cannon CP, Emanuelsson H, Husted S, Katus H, Skene A, Steg PG, Storey RF, Harrington R, Becker R, Wallentin L
Am Heart J 2009 Apr;157(4):599-605. doi: 10.1016/j.ahj.2009.01.003. PMID: 19332184

Diagnosis

Precision medicine in cardiovascular therapeutics: Evaluating the role of pharmacogenetic analysis prior to drug treatment.
Ingelman-Sundberg M, Pirmohamed M
J Intern Med 2024 May;295(5):583-598. Epub 2024 Feb 11 doi: 10.1111/joim.13772. PMID: 38343077
Do patients benefit from omega-3 fatty acids?
Sherratt SCR, Mason RP, Libby P, Steg PG, Bhatt DL
Cardiovasc Res 2024 Feb 17;119(18):2884-2901. doi: 10.1093/cvr/cvad188. PMID: 38252923Free PMC Article
Platelet reactivity testing in peripheral artery disease.
Zhang Y, Chou JW, Huang WT, Derry K, Humber D
Am J Health Syst Pharm 2022 Aug 5;79(16):1312-1322. doi: 10.1093/ajhp/zxac095. PMID: 35381075
Pharmacogenetics in Cardiovascular Medicine.
Weeke PE
Adv Pharmacol 2018;83:333-360. doi: 10.1016/bs.apha.2018.04.002. PMID: 29801582
Review of aspirin and clopidogrel resistance in peripheral arterial disease.
Guirgis M, Thompson P, Jansen S
J Vasc Surg 2017 Nov;66(5):1576-1586. doi: 10.1016/j.jvs.2017.07.065. PMID: 28893489

Therapy

Do patients benefit from omega-3 fatty acids?
Sherratt SCR, Mason RP, Libby P, Steg PG, Bhatt DL
Cardiovasc Res 2024 Feb 17;119(18):2884-2901. doi: 10.1093/cvr/cvad188. PMID: 38252923Free PMC Article
Safety and efficacy of factor XIa inhibition with milvexian for secondary stroke prevention (AXIOMATIC-SSP): a phase 2, international, randomised, double-blind, placebo-controlled, dose-finding trial.
Sharma M, Molina CA, Toyoda K, Bereczki D, Bangdiwala SI, Kasner SE, Lutsep HL, Tsivgoulis G, Ntaios G, Czlonkowska A, Shuaib A, Amarenco P, Endres M, Yoon BW, Tanne D, Toni D, Yperzeele L, von Weitzel-Mudersbach P, Sampaio Silva G, Avezum A, Dawson J, Strbian D, Tatlisumak T, Eckstein J, Ameriso SF, Weber JR, Sandset EC, Goar Pogosova N, Lavados PM, Arauz A, Gailani D, Diener HC, Bernstein RA, Cordonnier C, Kahl A, Abelian G, Donovan M, Pachai C, Li D, Hankey GJ
Lancet Neurol 2024 Jan;23(1):46-59. doi: 10.1016/S1474-4422(23)00403-9. PMID: 38101902Free PMC Article
Use of clopidogrel with or without aspirin in patients taking oral anticoagulant therapy and undergoing percutaneous coronary intervention: an open-label, randomised, controlled trial.
Dewilde WJ, Oirbans T, Verheugt FW, Kelder JC, De Smet BJ, Herrman JP, Adriaenssens T, Vrolix M, Heestermans AA, Vis MM, Tijsen JG, van 't Hof AW, ten Berg JM; WOEST study investigators
Lancet 2013 Mar 30;381(9872):1107-15. Epub 2013 Feb 13 doi: 10.1016/S0140-6736(12)62177-1. PMID: 23415013
Antiplatelet agents.
Varon D, Spectre G
Hematology Am Soc Hematol Educ Program 2009:267-72. doi: 10.1182/asheducation-2009.1.267. PMID: 20008209
Comparison of ticagrelor, the first reversible oral P2Y(12) receptor antagonist, with clopidogrel in patients with acute coronary syndromes: Rationale, design, and baseline characteristics of the PLATelet inhibition and patient Outcomes (PLATO) trial.
James S, Akerblom A, Cannon CP, Emanuelsson H, Husted S, Katus H, Skene A, Steg PG, Storey RF, Harrington R, Becker R, Wallentin L
Am Heart J 2009 Apr;157(4):599-605. doi: 10.1016/j.ahj.2009.01.003. PMID: 19332184

Prognosis

Review of aspirin and clopidogrel resistance in peripheral arterial disease.
Guirgis M, Thompson P, Jansen S
J Vasc Surg 2017 Nov;66(5):1576-1586. doi: 10.1016/j.jvs.2017.07.065. PMID: 28893489
Drug-drug interactions between clopidogrel and novel cardiovascular drugs.
Pelliccia F, Rollini F, Marazzi G, Greco C, Gaudio C, Angiolillo DJ
Eur J Pharmacol 2015 Oct 15;765:332-6. Epub 2015 Sep 2 doi: 10.1016/j.ejphar.2015.08.059. PMID: 26341013
Genetically Determined Platelet Reactivity and Related Clinical Implications.
Strisciuglio T, Di Gioia G, De Biase C, Esposito M, Franco D, Trimarco B, Barbato E
High Blood Press Cardiovasc Prev 2015 Sep;22(3):257-64. Epub 2015 May 19 doi: 10.1007/s40292-015-0104-5. PMID: 25986078
Use of clopidogrel with or without aspirin in patients taking oral anticoagulant therapy and undergoing percutaneous coronary intervention: an open-label, randomised, controlled trial.
Dewilde WJ, Oirbans T, Verheugt FW, Kelder JC, De Smet BJ, Herrman JP, Adriaenssens T, Vrolix M, Heestermans AA, Vis MM, Tijsen JG, van 't Hof AW, ten Berg JM; WOEST study investigators
Lancet 2013 Mar 30;381(9872):1107-15. Epub 2013 Feb 13 doi: 10.1016/S0140-6736(12)62177-1. PMID: 23415013
Comparison of ticagrelor, the first reversible oral P2Y(12) receptor antagonist, with clopidogrel in patients with acute coronary syndromes: Rationale, design, and baseline characteristics of the PLATelet inhibition and patient Outcomes (PLATO) trial.
James S, Akerblom A, Cannon CP, Emanuelsson H, Husted S, Katus H, Skene A, Steg PG, Storey RF, Harrington R, Becker R, Wallentin L
Am Heart J 2009 Apr;157(4):599-605. doi: 10.1016/j.ahj.2009.01.003. PMID: 19332184

Clinical prediction guides

Do patients benefit from omega-3 fatty acids?
Sherratt SCR, Mason RP, Libby P, Steg PG, Bhatt DL
Cardiovasc Res 2024 Feb 17;119(18):2884-2901. doi: 10.1093/cvr/cvad188. PMID: 38252923Free PMC Article
Safety and efficacy of factor XIa inhibition with milvexian for secondary stroke prevention (AXIOMATIC-SSP): a phase 2, international, randomised, double-blind, placebo-controlled, dose-finding trial.
Sharma M, Molina CA, Toyoda K, Bereczki D, Bangdiwala SI, Kasner SE, Lutsep HL, Tsivgoulis G, Ntaios G, Czlonkowska A, Shuaib A, Amarenco P, Endres M, Yoon BW, Tanne D, Toni D, Yperzeele L, von Weitzel-Mudersbach P, Sampaio Silva G, Avezum A, Dawson J, Strbian D, Tatlisumak T, Eckstein J, Ameriso SF, Weber JR, Sandset EC, Goar Pogosova N, Lavados PM, Arauz A, Gailani D, Diener HC, Bernstein RA, Cordonnier C, Kahl A, Abelian G, Donovan M, Pachai C, Li D, Hankey GJ
Lancet Neurol 2024 Jan;23(1):46-59. doi: 10.1016/S1474-4422(23)00403-9. PMID: 38101902Free PMC Article
Impact of body mass index on efficacy and safety of ticagrelor versus clopidogrel in patients with minor stroke or transient ischemic attack.
Zhang J, Wang A, Tian X, Meng X, Xie X, Jing J, Lin J, Wang Y, Li Z, Liu L, Li H, Jiang Y, Zhao X, Wang Y
CMAJ 2023 Jul 10;195(26):E897-E904. doi: 10.1503/cmaj.230262. PMID: 37429630Free PMC Article
Genetics of platelet inhibitor treatment.
Trenk D, Hochholzer W
Br J Clin Pharmacol 2014 Apr;77(4):642-53. doi: 10.1111/bcp.12230. PMID: 23981082Free PMC Article
Antiplatelet agents.
Varon D, Spectre G
Hematology Am Soc Hematol Educ Program 2009:267-72. doi: 10.1182/asheducation-2009.1.267. PMID: 20008209

Recent systematic reviews

Role of genetic polymorphisms in clopidogrel response variability: a systematic review.
Lopez J, Mark J, Duarte GJ, Shaban M, Sosa F, Mishra R, Jain S, Tran A, Khizar A, Karpel D, Acosta G, Rodriguez-Guerra M
Open Heart 2023 Nov;10(2) doi: 10.1136/openhrt-2023-002436. PMID: 37963685Free PMC Article
Reduced-Dose Prasugrel versus Clopidogrel for Patients Undergoing Percutaneous Coronary Intervention.
Lee CH, Huang MS, Chao TH, Lin SH, Li YH
Int Heart J 2021 Mar 30;62(2):246-255. Epub 2021 Mar 17 doi: 10.1536/ihj.20-508. PMID: 33731521
The impact of smoking on clinical efficacy and pharmacodynamic effects of clopidogrel: a systematic review and meta-analysis.
Zhao ZG, Chen M, Peng Y, Chai H, Liu W, Li Q, Ren X, Wang XQ, Luo XL, Zhang C, Huang DJ
Heart 2014 Feb;100(3):192-9. Epub 2013 Jun 8 doi: 10.1136/heartjnl-2013-304138. PMID: 23749792
High-maintenance-dose clopidogrel in patients undergoing percutaneous coronary intervention: a systematic review and meta-analysis.
Chen Y, Zhang Y, Tang Y, Huang X, Xie Y
PLoS One 2013;8(10):e78549. Epub 2013 Oct 23 doi: 10.1371/journal.pone.0078549. PMID: 24194947Free PMC Article
Impact of clopidogrel loading dose on clinical outcome in patients undergoing percutaneous coronary intervention: a systematic review and meta-analysis.
Siller-Matula JM, Huber K, Christ G, Schrör K, Kubica J, Herkner H, Jilma B
Heart 2011 Jan;97(2):98-105. Epub 2010 Aug 23 doi: 10.1136/hrt.2010.195438. PMID: 20736210

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