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warfarin response - Dosage

MedGen UID:
1002129
•Concept ID:
CN322729
•
Sign or Symptom

Professional guidelines

PubMed

Optimizing the dynamic treatment regime of in-hospital warfarin anticoagulation in patients after surgical valve replacement using reinforcement learning.
Zeng J, Shao J, Lin S, Zhang H, Su X, Lian X, Zhao Y, Ji X, Zheng Z
J Am Med Inform Assoc 2022 Sep 12;29(10):1722-1732. doi: 10.1093/jamia/ocac088. PMID: 35864720Free PMC Article

Recent clinical studies

Etiology

Rivaroxaban Versus Warfarin in Patients with Mechanical Heart Valves: Open-Label, Proof-of-Concept trial-The RIWA study.
Duraes AR, de Souza Lima Bitar Y, Schonhofen IS, Travassos KSO, Pereira LV, Filho JAL, Neto MG, Junior RA, Roever L
Am J Cardiovasc Drugs 2021 May;21(3):363-371. Epub 2020 Nov 5 doi: 10.1007/s40256-020-00449-3. PMID: 33150497
Genotype-guided warfarin therapy: current status.
Tavares LC, Marcatto LR, Santos PCJL
Pharmacogenomics 2018 May;19(7):667-685. Epub 2018 Apr 27 doi: 10.2217/pgs-2017-0207. PMID: 29701078
Genotype-guided dosing of warfarin through modeling and simulation.
Deng J, Vozmediano V, Rodriguez M, Cavallari LH, Schmidt S
Eur J Pharm Sci 2017 Nov 15;109S:S9-S14. Epub 2017 May 11 doi: 10.1016/j.ejps.2017.05.017. PMID: 28502675
The pharmacogenetics of the response to warfarin in Chinese.
Lam MP, Cheung BM
Br J Clin Pharmacol 2012 Mar;73(3):340-7. doi: 10.1111/j.1365-2125.2011.04097.x. PMID: 22023024Free PMC Article
Warfarin pharmacogenetics.
Limdi NA, Veenstra DL
Pharmacotherapy 2008 Sep;28(9):1084-97. doi: 10.1592/phco.28.9.1084. PMID: 18752379Free PMC Article

Diagnosis

Real-world use of apixaban for the treatment and prevention of thrombosis in children with cardiac disease.
VanderPluym C, Esteso P, Ankola A, Hellinger A, Ventresco C, Hawkins B, Kobayashi RL, Williams R, Cetatoiu MA, Gauvreau K, Esch JJ
J Thromb Haemost 2023 Jun;21(6):1601-1609. Epub 2023 Mar 14 doi: 10.1016/j.jtha.2023.03.005. PMID: 36921920
Diagnosis, prognosis and therapeutic management of acute pulmonary embolism.
Tapson VF
Hosp Pract (1995) 2016 Aug;44(3):164-72. Epub 2016 Jul 29 doi: 10.1080/21548331.2016.1210471. PMID: 27450108
Efficacy and safety of rivaroxaban compared with warfarin among elderly patients with nonvalvular atrial fibrillation in the Rivaroxaban Once Daily, Oral, Direct Factor Xa Inhibition Compared With Vitamin K Antagonism for Prevention of Stroke and Embolism Trial in Atrial Fibrillation (ROCKET AF).
Halperin JL, Hankey GJ, Wojdyla DM, Piccini JP, Lokhnygina Y, Patel MR, Breithardt G, Singer DE, Becker RC, Hacke W, Paolini JF, Nessel CC, Mahaffey KW, Califf RM, Fox KA; ROCKET AF Steering Committee and Investigators
Circulation 2014 Jul 8;130(2):138-46. Epub 2014 Jun 3 doi: 10.1161/CIRCULATIONAHA.113.005008. PMID: 24895454
Feasibility and safety of uninterrupted rivaroxaban for periprocedural anticoagulation in patients undergoing radiofrequency ablation for atrial fibrillation: results from a multicenter prospective registry.
Lakkireddy D, Reddy YM, Di Biase L, Vallakati A, Mansour MC, Santangeli P, Gangireddy S, Swarup V, Chalhoub F, Atkins D, Bommana S, Verma A, Sanchez JE, Burkhardt JD, Barrett CD, Baheiry S, Ruskin J, Reddy V, Natale A
J Am Coll Cardiol 2014 Mar 18;63(10):982-8. Epub 2014 Jan 8 doi: 10.1016/j.jacc.2013.11.039. PMID: 24412445
Aspects of anticoagulation in children.
Payne JH
Br J Haematol 2010 Aug;150(3):259-77. Epub 2010 May 26 doi: 10.1111/j.1365-2141.2010.08225.x. PMID: 20528873

Therapy

Rivaroxaban Versus Warfarin in Patients with Mechanical Heart Valves: Open-Label, Proof-of-Concept trial-The RIWA study.
Duraes AR, de Souza Lima Bitar Y, Schonhofen IS, Travassos KSO, Pereira LV, Filho JAL, Neto MG, Junior RA, Roever L
Am J Cardiovasc Drugs 2021 May;21(3):363-371. Epub 2020 Nov 5 doi: 10.1007/s40256-020-00449-3. PMID: 33150497
Genotype-guided warfarin therapy: current status.
Tavares LC, Marcatto LR, Santos PCJL
Pharmacogenomics 2018 May;19(7):667-685. Epub 2018 Apr 27 doi: 10.2217/pgs-2017-0207. PMID: 29701078
Predicting warfarin dose.
Lazo-Langner A, Kovacs MJ
Curr Opin Pulm Med 2010 Sep;16(5):426-31. doi: 10.1097/MCP.0b013e32833b1c6c. PMID: 20473166
Warfarin pharmacogenomics.
Cavallari LH, Limdi NA
Curr Opin Mol Ther 2009 Jun;11(3):243-51. PMID: 19479657
Warfarin pharmacogenetics.
Limdi NA, Veenstra DL
Pharmacotherapy 2008 Sep;28(9):1084-97. doi: 10.1592/phco.28.9.1084. PMID: 18752379Free PMC Article

Prognosis

Cardiovascular Pharmacogenomics--Implications for Patients With CKD.
Cavallari LH, Mason DL
Adv Chronic Kidney Dis 2016 Mar;23(2):82-90. doi: 10.1053/j.ackd.2015.12.001. PMID: 26979147Free PMC Article
Non-vitamin K antagonist oral anticoagulants and antiphospholipid syndrome.
Sciascia S, Lopez-Pedrera C, Cecchi I, Pecoraro C, Roccatello D, Cuadrado MJ
Rheumatology (Oxford) 2016 Oct;55(10):1726-35. Epub 2016 Feb 3 doi: 10.1093/rheumatology/kev445. PMID: 26843482
Feasibility and safety of uninterrupted rivaroxaban for periprocedural anticoagulation in patients undergoing radiofrequency ablation for atrial fibrillation: results from a multicenter prospective registry.
Lakkireddy D, Reddy YM, Di Biase L, Vallakati A, Mansour MC, Santangeli P, Gangireddy S, Swarup V, Chalhoub F, Atkins D, Bommana S, Verma A, Sanchez JE, Burkhardt JD, Barrett CD, Baheiry S, Ruskin J, Reddy V, Natale A
J Am Coll Cardiol 2014 Mar 18;63(10):982-8. Epub 2014 Jan 8 doi: 10.1016/j.jacc.2013.11.039. PMID: 24412445
Predicting warfarin dose.
Lazo-Langner A, Kovacs MJ
Curr Opin Pulm Med 2010 Sep;16(5):426-31. doi: 10.1097/MCP.0b013e32833b1c6c. PMID: 20473166
Warfarin pharmacogenomics.
Cavallari LH, Limdi NA
Curr Opin Mol Ther 2009 Jun;11(3):243-51. PMID: 19479657

Clinical prediction guides

Feasibility and safety of uninterrupted rivaroxaban for periprocedural anticoagulation in patients undergoing radiofrequency ablation for atrial fibrillation: results from a multicenter prospective registry.
Lakkireddy D, Reddy YM, Di Biase L, Vallakati A, Mansour MC, Santangeli P, Gangireddy S, Swarup V, Chalhoub F, Atkins D, Bommana S, Verma A, Sanchez JE, Burkhardt JD, Barrett CD, Baheiry S, Ruskin J, Reddy V, Natale A
J Am Coll Cardiol 2014 Mar 18;63(10):982-8. Epub 2014 Jan 8 doi: 10.1016/j.jacc.2013.11.039. PMID: 24412445
Predicting warfarin dose.
Lazo-Langner A, Kovacs MJ
Curr Opin Pulm Med 2010 Sep;16(5):426-31. doi: 10.1097/MCP.0b013e32833b1c6c. PMID: 20473166
Evolution of pharmacogenomics.
Somogy A
Proc West Pharmacol Soc 2008;51:1-4. PMID: 19544663
Warfarin pharmacogenetics.
Limdi NA, Veenstra DL
Pharmacotherapy 2008 Sep;28(9):1084-97. doi: 10.1592/phco.28.9.1084. PMID: 18752379Free PMC Article
Ezetimibe: a review of its metabolism, pharmacokinetics and drug interactions.
Kosoglou T, Statkevich P, Johnson-Levonas AO, Paolini JF, Bergman AJ, Alton KB
Clin Pharmacokinet 2005;44(5):467-94. doi: 10.2165/00003088-200544050-00002. PMID: 15871634

Recent systematic reviews

The influence of VKORC1 gene polymorphism on warfarin maintenance dosage in pediatric patients: A systematic review and meta-analysis.
Zhang J, Tian L, Zhang Y, Shen J
Thromb Res 2015 Nov;136(5):955-61. Epub 2015 Sep 26 doi: 10.1016/j.thromres.2015.09.018. PMID: 26433837
Limited dose warfarin throughout pregnancy in patients with mechanical heart valve prosthesis: a meta-analysis.
Hassouna A, Allam H
Interact Cardiovasc Thorac Surg 2014 Jun;18(6):797-806. Epub 2014 Mar 4 doi: 10.1093/icvts/ivu009. PMID: 24595247
Anticoagulation control with daily low-dose vitamin k to reduce clinically adverse outcomes and international normalized ratio variability: a systematic review and meta-analysis.
Lam J, Schulman S, Witt DM, Vandvik PO, Qayyum F, Holbrook AM
Pharmacotherapy 2013 Nov;33(11):1184-90. Epub 2013 Jun 6 doi: 10.1002/phar.1302. PMID: 23744743
Influence of CYP2C9 and VKORC1 on patient response to warfarin: a systematic review and meta-analysis.
Jorgensen AL, FitzGerald RJ, Oyee J, Pirmohamed M, Williamson PR
PLoS One 2012;7(8):e44064. Epub 2012 Aug 29 doi: 10.1371/journal.pone.0044064. PMID: 22952875Free PMC Article
Brand name versus generic warfarin: a systematic review of the literature.
Dentali F, Donadini MP, Clark N, Crowther MA, Garcia D, Hylek E, Witt DM, Ageno W; Warfarin Associated Research Projects and Other Endeavors (WARPED) Consortium
Pharmacotherapy 2011 Apr;31(4):386-93. doi: 10.1592/phco.31.4.386. PMID: 21449627

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