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methotrexate response - Efficacy

MedGen UID:
1003418
•Concept ID:
CN322736
•
Sign or Symptom

Professional guidelines

PubMed

Challenges and Future Trends in the Treatment of Psoriasis.
Lee HJ, Kim M
Int J Mol Sci 2023 Aug 28;24(17) doi: 10.3390/ijms241713313. PMID: 37686119Free PMC Article
Primary central nervous system lymphoma.
Ferreri AJM, Calimeri T, Cwynarski K, Dietrich J, Grommes C, Hoang-Xuan K, Hu LS, Illerhaus G, Nayak L, Ponzoni M, Batchelor TT
Nat Rev Dis Primers 2023 Jun 15;9(1):29. doi: 10.1038/s41572-023-00439-0. PMID: 37322012Free PMC Article
EULAR recommendations for the management of rheumatoid arthritis with synthetic and biological disease-modifying antirheumatic drugs: 2022 update.
Smolen JS, Landewé RBM, Bergstra SA, Kerschbaumer A, Sepriano A, Aletaha D, Caporali R, Edwards CJ, Hyrich KL, Pope JE, de Souza S, Stamm TA, Takeuchi T, Verschueren P, Winthrop KL, Balsa A, Bathon JM, Buch MH, Burmester GR, Buttgereit F, Cardiel MH, Chatzidionysiou K, Codreanu C, Cutolo M, den Broeder AA, El Aoufy K, Finckh A, Fonseca JE, Gottenberg JE, Haavardsholm EA, Iagnocco A, Lauper K, Li Z, McInnes IB, Mysler EF, Nash P, Poor G, Ristic GG, Rivellese F, Rubbert-Roth A, Schulze-Koops H, Stoilov N, Strangfeld A, van der Helm-van Mil A, van Duuren E, Vliet Vlieland TPM, Westhovens R, van der Heijde D
Ann Rheum Dis 2023 Jan;82(1):3-18. Epub 2022 Nov 10 doi: 10.1136/ard-2022-223356. PMID: 36357155

Recent clinical studies

Etiology

Efficacy of Methotrexate Alone vs Methotrexate Plus Low-Dose Prednisone in Patients With Alopecia Areata Totalis or Universalis: A 2-Step Double-Blind Randomized Clinical Trial.
Joly P, Lafon A, Houivet E, Donnadieu N, Richard MA, Dupuy A, Delaporte E, Bernard P, Machet L, Tosti A, Del Marmol V, Grimalt R, de Viragh PA, Benichou J, Chosidow O, Assouly P, Reygagne P
JAMA Dermatol 2023 Apr 1;159(4):403-410. doi: 10.1001/jamadermatol.2022.6687. PMID: 36884234Free PMC Article
Comparative efficacy and safety of JAK inhibitors as monotherapy and in combination with methotrexate in patients with active rheumatoid arthritis: A systematic review and meta-analysis.
Liu L, Yan YD, Shi FH, Lin HW, Gu ZC, Li J
Front Immunol 2022;13:977265. Epub 2022 Sep 29 doi: 10.3389/fimmu.2022.977265. PMID: 36248913Free PMC Article
Upadacitinib as monotherapy in patients with active rheumatoid arthritis and inadequate response to methotrexate (SELECT-MONOTHERAPY): a randomised, placebo-controlled, double-blind phase 3 study.
Smolen JS, Pangan AL, Emery P, Rigby W, Tanaka Y, Vargas JI, Zhang Y, Damjanov N, Friedman A, Othman AA, Camp HS, Cohen S
Lancet 2019 Jun 8;393(10188):2303-2311. Epub 2019 May 23 doi: 10.1016/S0140-6736(19)30419-2. PMID: 31130260
Etanercept and Methotrexate as Monotherapy or in Combination for Psoriatic Arthritis: Primary Results From a Randomized, Controlled Phase III Trial.
Mease PJ, Gladman DD, Collier DH, Ritchlin CT, Helliwell PS, Liu L, Kricorian G, Chung JB
Arthritis Rheumatol 2019 Jul;71(7):1112-1124. Epub 2019 May 28 doi: 10.1002/art.40851. PMID: 30747501Free PMC Article
Efficacy and safety of tofacitinib monotherapy, tofacitinib with methotrexate, and adalimumab with methotrexate in patients with rheumatoid arthritis (ORAL Strategy): a phase 3b/4, double-blind, head-to-head, randomised controlled trial.
Fleischmann R, Mysler E, Hall S, Kivitz AJ, Moots RJ, Luo Z, DeMasi R, Soma K, Zhang R, Takiya L, Tatulych S, Mojcik C, Krishnaswami S, Menon S, Smolen JS; ORAL Strategy investigators
Lancet 2017 Jul 29;390(10093):457-468. Epub 2017 Jun 16 doi: 10.1016/S0140-6736(17)31618-5. PMID: 28629665

Diagnosis

High-Dose Methotrexate as CNS Prophylaxis in High-Risk Aggressive B-Cell Lymphoma.
Lewis KL, Jakobsen LH, Villa D, Smedby KE, Savage KJ, Eyre TA, Cwynarski K, Bishton MJ, Fox CP, Hawkes EA, Maurer MJ, El-Galaly TC, Cheah CY; International CNS Prophylaxis Study Group
J Clin Oncol 2023 Dec 10;41(35):5376-5387. Epub 2023 Oct 5 doi: 10.1200/JCO.23.00365. PMID: 37797284
Characterization of stem cell landscape and identification of stemness-relevant prognostic gene signature to aid immunotherapy in colorectal cancer.
Zheng H, Liu H, Li H, Dou W, Wang J, Zhang J, Liu T, Wu Y, Liu Y, Wang X
Stem Cell Res Ther 2022 Jun 9;13(1):244. doi: 10.1186/s13287-022-02913-0. PMID: 35681225Free PMC Article
Treatment of relapsing polychondritis: a systematic review.
Petitdemange A, Sztejkowski C, Damian L, Martin T, Mouthon L, Amoura Z, Cutolo M, Burmester GR, Fonseca JE, Rednic S, Arnaud L
Clin Exp Rheumatol 2022 May;40 Suppl 134(5):81-85. Epub 2022 Jan 28 doi: 10.55563/clinexprheumatol/h9gq1o. PMID: 35238756
Interventions for cutaneous disease in systemic lupus erythematosus.
Hannon CW, McCourt C, Lima HC, Chen S, Bennett C
Cochrane Database Syst Rev 2021 Mar 9;3(3):CD007478. doi: 10.1002/14651858.CD007478.pub2. PMID: 33687069Free PMC Article
Rituximab, methotrexate, procarbazine, and vincristine followed by consolidation reduced-dose whole-brain radiotherapy and cytarabine in newly diagnosed primary CNS lymphoma: final results and long-term outcome.
Morris PG, Correa DD, Yahalom J, Raizer JJ, Schiff D, Grant B, Grimm S, Lai RK, Reiner AS, Panageas K, Karimi S, Curry R, Shah G, Abrey LE, DeAngelis LM, Omuro A
J Clin Oncol 2013 Nov 1;31(31):3971-9. Epub 2013 Oct 7 doi: 10.1200/JCO.2013.50.4910. PMID: 24101038Free PMC Article

Therapy

Efficacy of Methotrexate Alone vs Methotrexate Plus Low-Dose Prednisone in Patients With Alopecia Areata Totalis or Universalis: A 2-Step Double-Blind Randomized Clinical Trial.
Joly P, Lafon A, Houivet E, Donnadieu N, Richard MA, Dupuy A, Delaporte E, Bernard P, Machet L, Tosti A, Del Marmol V, Grimalt R, de Viragh PA, Benichou J, Chosidow O, Assouly P, Reygagne P
JAMA Dermatol 2023 Apr 1;159(4):403-410. doi: 10.1001/jamadermatol.2022.6687. PMID: 36884234Free PMC Article
Methotrexate: Implications of pharmacogenetics in the treatment of patients with Rheumatoid Arthritis.
Torres RP, Santos FP, Branco JC
ARP Rheumatol 2022 Oct 1;1(3):225-229. PMID: 35724450
Interventions for cutaneous disease in systemic lupus erythematosus.
Hannon CW, McCourt C, Lima HC, Chen S, Bennett C
Cochrane Database Syst Rev 2021 Mar 9;3(3):CD007478. doi: 10.1002/14651858.CD007478.pub2. PMID: 33687069Free PMC Article
Upadacitinib as monotherapy in patients with active rheumatoid arthritis and inadequate response to methotrexate (SELECT-MONOTHERAPY): a randomised, placebo-controlled, double-blind phase 3 study.
Smolen JS, Pangan AL, Emery P, Rigby W, Tanaka Y, Vargas JI, Zhang Y, Damjanov N, Friedman A, Othman AA, Camp HS, Cohen S
Lancet 2019 Jun 8;393(10188):2303-2311. Epub 2019 May 23 doi: 10.1016/S0140-6736(19)30419-2. PMID: 31130260
Comparison of the clinical efficacy and safety of subcutaneous versus oral administration of methotrexate in patients with active rheumatoid arthritis: results of a six-month, multicenter, randomized, double-blind, controlled, phase IV trial.
Braun J, Kästner P, Flaxenberg P, Währisch J, Hanke P, Demary W, von Hinüber U, Rockwitz K, Heitz W, Pichlmeier U, Guimbal-Schmolck C, Brandt A; MC-MTX.6/RH Study Group
Arthritis Rheum 2008 Jan;58(1):73-81. doi: 10.1002/art.23144. PMID: 18163521

Prognosis

High-Dose Methotrexate as CNS Prophylaxis in High-Risk Aggressive B-Cell Lymphoma.
Lewis KL, Jakobsen LH, Villa D, Smedby KE, Savage KJ, Eyre TA, Cwynarski K, Bishton MJ, Fox CP, Hawkes EA, Maurer MJ, El-Galaly TC, Cheah CY; International CNS Prophylaxis Study Group
J Clin Oncol 2023 Dec 10;41(35):5376-5387. Epub 2023 Oct 5 doi: 10.1200/JCO.23.00365. PMID: 37797284
Successful Outcomes of Newly Diagnosed T Lymphoblastic Lymphoma: Results From Children's Oncology Group AALL0434.
Hayashi RJ, Winter SS, Dunsmore KP, Devidas M, Chen Z, Wood BL, Hermiston ML, Teachey DT, Perkins SL, Miles RR, Raetz EA, Loh ML, Winick NJ, Carroll WL, Hunger SP, Lim MS, Gross TG, Bollard CM
J Clin Oncol 2020 Sep 10;38(26):3062-3070. Epub 2020 Jun 17 doi: 10.1200/JCO.20.00531. PMID: 32552472Free PMC Article
Rituximab, methotrexate, procarbazine, and vincristine followed by consolidation reduced-dose whole-brain radiotherapy and cytarabine in newly diagnosed primary CNS lymphoma: final results and long-term outcome.
Morris PG, Correa DD, Yahalom J, Raizer JJ, Schiff D, Grant B, Grimm S, Lai RK, Reiner AS, Panageas K, Karimi S, Curry R, Shah G, Abrey LE, DeAngelis LM, Omuro A
J Clin Oncol 2013 Nov 1;31(31):3971-9. Epub 2013 Oct 7 doi: 10.1200/JCO.2013.50.4910. PMID: 24101038Free PMC Article
Randomized phase II/III trial assessing gemcitabine/carboplatin and methotrexate/carboplatin/vinblastine in patients with advanced urothelial cancer who are unfit for cisplatin-based chemotherapy: EORTC study 30986.
De Santis M, Bellmunt J, Mead G, Kerst JM, Leahy M, Maroto P, Gil T, Marreaud S, Daugaard G, Skoneczna I, Collette S, Lorent J, de Wit R, Sylvester R
J Clin Oncol 2012 Jan 10;30(2):191-9. Epub 2011 Dec 12 doi: 10.1200/JCO.2011.37.3571. PMID: 22162575Free PMC Article
Measuring methotrexate polyglutamates.
Goodman S
Clin Exp Rheumatol 2010 Sep-Oct;28(5 Suppl 61):S24-6. Epub 2010 Oct 28 PMID: 21044429

Clinical prediction guides

Efficacy of Methotrexate Alone vs Methotrexate Plus Low-Dose Prednisone in Patients With Alopecia Areata Totalis or Universalis: A 2-Step Double-Blind Randomized Clinical Trial.
Joly P, Lafon A, Houivet E, Donnadieu N, Richard MA, Dupuy A, Delaporte E, Bernard P, Machet L, Tosti A, Del Marmol V, Grimalt R, de Viragh PA, Benichou J, Chosidow O, Assouly P, Reygagne P
JAMA Dermatol 2023 Apr 1;159(4):403-410. doi: 10.1001/jamadermatol.2022.6687. PMID: 36884234Free PMC Article
Comparative efficacy and safety of JAK inhibitors as monotherapy and in combination with methotrexate in patients with active rheumatoid arthritis: A systematic review and meta-analysis.
Liu L, Yan YD, Shi FH, Lin HW, Gu ZC, Li J
Front Immunol 2022;13:977265. Epub 2022 Sep 29 doi: 10.3389/fimmu.2022.977265. PMID: 36248913Free PMC Article
Upadacitinib as monotherapy in patients with active rheumatoid arthritis and inadequate response to methotrexate (SELECT-MONOTHERAPY): a randomised, placebo-controlled, double-blind phase 3 study.
Smolen JS, Pangan AL, Emery P, Rigby W, Tanaka Y, Vargas JI, Zhang Y, Damjanov N, Friedman A, Othman AA, Camp HS, Cohen S
Lancet 2019 Jun 8;393(10188):2303-2311. Epub 2019 May 23 doi: 10.1016/S0140-6736(19)30419-2. PMID: 31130260
Etanercept and Methotrexate as Monotherapy or in Combination for Psoriatic Arthritis: Primary Results From a Randomized, Controlled Phase III Trial.
Mease PJ, Gladman DD, Collier DH, Ritchlin CT, Helliwell PS, Liu L, Kricorian G, Chung JB
Arthritis Rheumatol 2019 Jul;71(7):1112-1124. Epub 2019 May 28 doi: 10.1002/art.40851. PMID: 30747501Free PMC Article
Comparison of the clinical efficacy and safety of subcutaneous versus oral administration of methotrexate in patients with active rheumatoid arthritis: results of a six-month, multicenter, randomized, double-blind, controlled, phase IV trial.
Braun J, Kästner P, Flaxenberg P, Währisch J, Hanke P, Demary W, von Hinüber U, Rockwitz K, Heitz W, Pichlmeier U, Guimbal-Schmolck C, Brandt A; MC-MTX.6/RH Study Group
Arthritis Rheum 2008 Jan;58(1):73-81. doi: 10.1002/art.23144. PMID: 18163521

Recent systematic reviews

Evaluating the efficacy of biologics with and without methotrexate in the treatment of psoriatic arthritis: a network meta-analysis.
Mease PJ, Reddy S, Ross S, Lisse JR, Reis P, Griffing K, Sapin C, Vadhariya A, Furst DE
RMD Open 2024 Jan 31;10(1) doi: 10.1136/rmdopen-2023-003423. PMID: 38296801Free PMC Article
Efficacy of synthetic and biological DMARDs: a systematic literature review informing the 2022 update of the EULAR recommendations for the management of rheumatoid arthritis.
Kerschbaumer A, Sepriano A, Bergstra SA, Smolen JS, van der Heijde D, Caporali R, Edwards CJ, Verschueren P, de Souza S, Pope JE, Takeuchi T, Hyrich KL, Winthrop KL, Aletaha D, Stamm TA, Schoones JW, Landewé RBM
Ann Rheum Dis 2023 Jan;82(1):95-106. Epub 2022 Nov 11 doi: 10.1136/ard-2022-223365. PMID: 36368906
Comparative efficacy and safety of JAK inhibitors as monotherapy and in combination with methotrexate in patients with active rheumatoid arthritis: A systematic review and meta-analysis.
Liu L, Yan YD, Shi FH, Lin HW, Gu ZC, Li J
Front Immunol 2022;13:977265. Epub 2022 Sep 29 doi: 10.3389/fimmu.2022.977265. PMID: 36248913Free PMC Article
Treatment of relapsing polychondritis: a systematic review.
Petitdemange A, Sztejkowski C, Damian L, Martin T, Mouthon L, Amoura Z, Cutolo M, Burmester GR, Fonseca JE, Rednic S, Arnaud L
Clin Exp Rheumatol 2022 May;40 Suppl 134(5):81-85. Epub 2022 Jan 28 doi: 10.55563/clinexprheumatol/h9gq1o. PMID: 35238756
Interventions for cutaneous disease in systemic lupus erythematosus.
Hannon CW, McCourt C, Lima HC, Chen S, Bennett C
Cochrane Database Syst Rev 2021 Mar 9;3(3):CD007478. doi: 10.1002/14651858.CD007478.pub2. PMID: 33687069Free PMC Article

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