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salmeterol response - Efficacy

MedGen UID:
1003453
•Concept ID:
CN322739
•
Sign or Symptom

Professional guidelines

PubMed

How can the findings of the EMAX trial on long-acting bronchodilation in chronic obstructive pulmonary disease be applied in the primary care setting?
Kerwin EM, Jones PW, Bjermer LH, Maltais F, Boucot IH, Naya IP, Lipson DA, Compton C, Tombs L, Vogelmeier CF
Chron Respir Dis 2023 Jan-Dec;20:14799731231202257. doi: 10.1177/14799731231202257. PMID: 37800633Free PMC Article
Genetic effects on efficacy to fluticasone propionate/salmeterol treatment in COPD.
Condreay LD, Qu XA, Anderson J, Compton C, Ghosh S
Respir Med 2019 Aug;155:51-53. Epub 2019 Jun 29 doi: 10.1016/j.rmed.2019.06.023. PMID: 31299468
Clinical utility and development of the fluticasone/formoterol combination formulation (Flutiform(®)) for the treatment of asthma.
Tan RA, Corren J
Drug Des Devel Ther 2014;8:1555-61. Epub 2014 Sep 30 doi: 10.2147/DDDT.S36556. PMID: 25328383Free PMC Article

Recent clinical studies

Etiology

How can the findings of the EMAX trial on long-acting bronchodilation in chronic obstructive pulmonary disease be applied in the primary care setting?
Kerwin EM, Jones PW, Bjermer LH, Maltais F, Boucot IH, Naya IP, Lipson DA, Compton C, Tombs L, Vogelmeier CF
Chron Respir Dis 2023 Jan-Dec;20:14799731231202257. doi: 10.1177/14799731231202257. PMID: 37800633Free PMC Article
Once-daily, single-inhaler mometasone-indacaterol-glycopyrronium versus mometasone-indacaterol or twice-daily fluticasone-salmeterol in patients with inadequately controlled asthma (IRIDIUM): a randomised, double-blind, controlled phase 3 study.
Kerstjens HAM, Maspero J, Chapman KR, van Zyl-Smit RN, Hosoe M, Tanase AM, Lavecchia C, Pethe A, Shu X, D'Andrea P; IRIDIUM trial investigators
Lancet Respir Med 2020 Oct;8(10):1000-1012. Epub 2020 Jul 9 doi: 10.1016/S2213-2600(20)30190-9. PMID: 32653074
Pharmacogenetics: implications of race and ethnicity on defining genetic profiles for personalized medicine.
Ortega VE, Meyers DA
J Allergy Clin Immunol 2014 Jan;133(1):16-26. doi: 10.1016/j.jaci.2013.10.040. PMID: 24369795Free PMC Article
Inhaled bronchodilators for cystic fibrosis.
Halfhide C, Evans HJ, Couriel J
Cochrane Database Syst Rev 2005 Oct 19;(4):CD003428. doi: 10.1002/14651858.CD003428.pub2. PMID: 16235319
Gender does not influence the response to the combination of salmeterol and fluticasone propionate in COPD.
Vestbo J, Soriano JB, Anderson JA, Calverley P, Pauwels R, Jones P; TRISTAN Study Group
Respir Med 2004 Nov;98(11):1045-50. doi: 10.1016/j.rmed.2004.03.017. PMID: 15526804

Diagnosis

Bronchodilator reversibility testing in morbidly obese non-smokers: fluticasone/salmeterol efficacy versus salbutamol bronchodilator.
Ahmed MI, Ahmed RI, Osama H, Khalifa AK, Alshehri AA, El-Saber Batiha G, Negm WA, Kamal M
BMC Pulm Med 2023 Oct 9;23(1):381. doi: 10.1186/s12890-023-02682-3. PMID: 37814253Free PMC Article
Comparative efficacy of long-acting β2-agonists as monotherapy for chronic obstructive pulmonary disease: a network meta-analysis.
Donohue JF, Betts KA, Du EX, Altman P, Goyal P, Keininger DL, Gruenberger JB, Signorovitch JE
Int J Chron Obstruct Pulmon Dis 2017;12:367-381. Epub 2017 Jan 19 doi: 10.2147/COPD.S119908. PMID: 28176892Free PMC Article
Controversies regarding long-acting β2-agonists.
Khianey R, Oppenheimer J
Curr Opin Allergy Clin Immunol 2011 Aug;11(4):345-54. doi: 10.1097/ACI.0b013e328348a82e. PMID: 21659855
Inhaled bronchodilators for cystic fibrosis.
Halfhide C, Evans HJ, Couriel J
Cochrane Database Syst Rev 2005 Oct 19;(4):CD003428. doi: 10.1002/14651858.CD003428.pub2. PMID: 16235319
Gender does not influence the response to the combination of salmeterol and fluticasone propionate in COPD.
Vestbo J, Soriano JB, Anderson JA, Calverley P, Pauwels R, Jones P; TRISTAN Study Group
Respir Med 2004 Nov;98(11):1045-50. doi: 10.1016/j.rmed.2004.03.017. PMID: 15526804

Therapy

How can the findings of the EMAX trial on long-acting bronchodilation in chronic obstructive pulmonary disease be applied in the primary care setting?
Kerwin EM, Jones PW, Bjermer LH, Maltais F, Boucot IH, Naya IP, Lipson DA, Compton C, Tombs L, Vogelmeier CF
Chron Respir Dis 2023 Jan-Dec;20:14799731231202257. doi: 10.1177/14799731231202257. PMID: 37800633Free PMC Article
The efficacy and mechanism of salmeterol against influenza A virus in vitro and in vivo.
Zhao J, Xu L, Bai Y, Wang C, Guo P, Wang Z, Du G, Liu A
Int Immunopharmacol 2023 Jun;119:110226. Epub 2023 May 7 doi: 10.1016/j.intimp.2023.110226. PMID: 37159964
Once-daily, single-inhaler mometasone-indacaterol-glycopyrronium versus mometasone-indacaterol or twice-daily fluticasone-salmeterol in patients with inadequately controlled asthma (IRIDIUM): a randomised, double-blind, controlled phase 3 study.
Kerstjens HAM, Maspero J, Chapman KR, van Zyl-Smit RN, Hosoe M, Tanase AM, Lavecchia C, Pethe A, Shu X, D'Andrea P; IRIDIUM trial investigators
Lancet Respir Med 2020 Oct;8(10):1000-1012. Epub 2020 Jul 9 doi: 10.1016/S2213-2600(20)30190-9. PMID: 32653074
Repurposing drugs as inhaled therapies in asthma.
Anderson SD
Adv Drug Deliv Rev 2018 Aug;133:19-33. Epub 2018 Jun 12 doi: 10.1016/j.addr.2018.06.006. PMID: 29906501
Controversies regarding long-acting β2-agonists.
Khianey R, Oppenheimer J
Curr Opin Allergy Clin Immunol 2011 Aug;11(4):345-54. doi: 10.1097/ACI.0b013e328348a82e. PMID: 21659855

Prognosis

Bronchodilator reversibility testing in morbidly obese non-smokers: fluticasone/salmeterol efficacy versus salbutamol bronchodilator.
Ahmed MI, Ahmed RI, Osama H, Khalifa AK, Alshehri AA, El-Saber Batiha G, Negm WA, Kamal M
BMC Pulm Med 2023 Oct 9;23(1):381. doi: 10.1186/s12890-023-02682-3. PMID: 37814253Free PMC Article
Once-daily, single-inhaler mometasone-indacaterol-glycopyrronium versus mometasone-indacaterol or twice-daily fluticasone-salmeterol in patients with inadequately controlled asthma (IRIDIUM): a randomised, double-blind, controlled phase 3 study.
Kerstjens HAM, Maspero J, Chapman KR, van Zyl-Smit RN, Hosoe M, Tanase AM, Lavecchia C, Pethe A, Shu X, D'Andrea P; IRIDIUM trial investigators
Lancet Respir Med 2020 Oct;8(10):1000-1012. Epub 2020 Jul 9 doi: 10.1016/S2213-2600(20)30190-9. PMID: 32653074
The use of long acting β₂-agonists, alone or in combination with inhaled corticosteroids, in chronic obstructive pulmonary disease (COPD): a risk-benefit analysis.
Cave AC, Hurst MM
Pharmacol Ther 2011 May;130(2):114-43. Epub 2011 Jan 27 doi: 10.1016/j.pharmthera.2010.12.008. PMID: 21276815
Comparison of the efficacy of salmeterol/fluticasone propionate combination in Japanese and Caucasian asthmatics.
Kawai M, Kempsford R, Pullerits T, Takaori S, Hashimoto K, Takemoto Y, Lötvall J
Respir Med 2007 Dec;101(12):2488-94. Epub 2007 Sep 27 doi: 10.1016/j.rmed.2007.07.001. PMID: 17900887
Efficacy and safety of salmeterol in childhood asthma.
Lenney W, Pedersen S, Boner AL, Ebbutt A, Jenkins MM
Eur J Pediatr 1995 Dec;154(12):983-90. doi: 10.1007/BF01958642. PMID: 8801107

Clinical prediction guides

Bronchodilator reversibility testing in morbidly obese non-smokers: fluticasone/salmeterol efficacy versus salbutamol bronchodilator.
Ahmed MI, Ahmed RI, Osama H, Khalifa AK, Alshehri AA, El-Saber Batiha G, Negm WA, Kamal M
BMC Pulm Med 2023 Oct 9;23(1):381. doi: 10.1186/s12890-023-02682-3. PMID: 37814253Free PMC Article
How can the findings of the EMAX trial on long-acting bronchodilation in chronic obstructive pulmonary disease be applied in the primary care setting?
Kerwin EM, Jones PW, Bjermer LH, Maltais F, Boucot IH, Naya IP, Lipson DA, Compton C, Tombs L, Vogelmeier CF
Chron Respir Dis 2023 Jan-Dec;20:14799731231202257. doi: 10.1177/14799731231202257. PMID: 37800633Free PMC Article
Once-daily, single-inhaler mometasone-indacaterol-glycopyrronium versus mometasone-indacaterol or twice-daily fluticasone-salmeterol in patients with inadequately controlled asthma (IRIDIUM): a randomised, double-blind, controlled phase 3 study.
Kerstjens HAM, Maspero J, Chapman KR, van Zyl-Smit RN, Hosoe M, Tanase AM, Lavecchia C, Pethe A, Shu X, D'Andrea P; IRIDIUM trial investigators
Lancet Respir Med 2020 Oct;8(10):1000-1012. Epub 2020 Jul 9 doi: 10.1016/S2213-2600(20)30190-9. PMID: 32653074
Comparative efficacy of long-acting β2-agonists as monotherapy for chronic obstructive pulmonary disease: a network meta-analysis.
Donohue JF, Betts KA, Du EX, Altman P, Goyal P, Keininger DL, Gruenberger JB, Signorovitch JE
Int J Chron Obstruct Pulmon Dis 2017;12:367-381. Epub 2017 Jan 19 doi: 10.2147/COPD.S119908. PMID: 28176892Free PMC Article
Zafirlukast: an update of its pharmacology and therapeutic efficacy in asthma.
Dunn CJ, Goa KL
Drugs 2001;61(2):285-315. doi: 10.2165/00003495-200161020-00012. PMID: 11270943

Recent systematic reviews

Comparing the efficacy and safety of formoterol/budesonide pMDI versus its mono-components and other LABA/ICS in patients with asthma.
Mukhopadhyay A, Waked M, Gogtay J, Gaur V
Respir Med 2020 Aug-Sep;170:106055. Epub 2020 Jun 1 doi: 10.1016/j.rmed.2020.106055. PMID: 32843176
Comparative efficacy of long-acting β2-agonists as monotherapy for chronic obstructive pulmonary disease: a network meta-analysis.
Donohue JF, Betts KA, Du EX, Altman P, Goyal P, Keininger DL, Gruenberger JB, Signorovitch JE
Int J Chron Obstruct Pulmon Dis 2017;12:367-381. Epub 2017 Jan 19 doi: 10.2147/COPD.S119908. PMID: 28176892Free PMC Article
Efficacy of once-daily indacaterol 75 μg relative to alternative bronchodilators in COPD: a study level and a patient level network meta-analysis.
Cope S, Zhang J, Williams J, Jansen JP
BMC Pulm Med 2012 Jun 25;12:29. doi: 10.1186/1471-2466-12-29. PMID: 22732017Free PMC Article
Combined corticosteroid and long-acting beta-agonist in one inhaler versus inhaled steroids for chronic obstructive pulmonary disease.
Nannini LJ, Cates CJ, Lasserson TJ, Poole P
Cochrane Database Syst Rev 2007 Oct 17;(4):CD006826. doi: 10.1002/14651858.CD006826. PMID: 17943917Free PMC Article
Inhaled bronchodilators for cystic fibrosis.
Halfhide C, Evans HJ, Couriel J
Cochrane Database Syst Rev 2005 Oct 19;(4):CD003428. doi: 10.1002/14651858.CD003428.pub2. PMID: 16235319

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