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Leukemia/lymphoma, T-cell

MedGen UID:
1051178
•Concept ID:
CN375895
•
Disease or Syndrome
Genes (locations): TCL4 (2q34); TCL6 (14q32.13)

Professional guidelines

PubMed

Identifying highly active anti-CCR4 CAR T cells for the treatment of T-cell lymphoma.
Watanabe K, Gomez AM, Kuramitsu S, Siurala M, Da T, Agarwal S, Song D, Scholler J, Rotolo A, Posey AD, Rook AH, Haun PL, Ruella M, Young RM, June CH
Blood Adv 2023 Jul 25;7(14):3416-3430. doi: 10.1182/bloodadvances.2022008327. PMID: 37058474Free PMC Article
T cell lymphoma: time to make discoveries and advance treatment.
Ishitsuka K
Int J Hematol 2023 Apr;117(4):473-474. Epub 2023 Mar 14 doi: 10.1007/s12185-023-03573-3. PMID: 36918503
Revised Adult T-Cell Leukemia-Lymphoma International Consensus Meeting Report.
Cook LB, Fuji S, Hermine O, Bazarbachi A, Ramos JC, Ratner L, Horwitz S, Fields P, Tanase A, Bumbea H, Cwynarski K, Taylor G, Waldmann TA, Bittencourt A, Marcais A, Suarez F, Sibon D, Phillips A, Lunning M, Farid R, Imaizumi Y, Choi I, Ishida T, Ishitsuka K, Fukushima T, Uchimaru K, Takaori-Kondo A, Tokura Y, Utsunomiya A, Matsuoka M, Tsukasaki K, Watanabe T
J Clin Oncol 2019 Mar 10;37(8):677-687. Epub 2019 Jan 18 doi: 10.1200/JCO.18.00501. PMID: 30657736Free PMC Article

Recent clinical studies

Etiology

The expression of CD26 and CD40 ligand is mutually exclusive in human T-cell non-Hodgkin's lymphomas/leukemias.
Carbone A, Gloghini A, Zagonel V, Aldinucci D, Gattei V, Degan M, Improta S, Sorio R, Monfardini S, Pinto A
Blood 1995 Dec 15;86(12):4617-26. PMID: 8541553
On the expression of HMG I protein in quiescent and proliferating human T lymphocytes.
Jyranoja BD, Lund T, Lea T, Laland SG
Biochem Int 1991 May;24(2):217-23. PMID: 1930245

Diagnosis

CD26 expression correlates with a reduced sensitivity to 2'-deoxycoformycin-induced growth inhibition and apoptosis in T-cell leukemia/lymphomas.
Aldinucci D, Poletto D, Lorenzon D, Nanni P, Degan M, Olivo K, Rapanà B, Pinto A, Gattei V
Clin Cancer Res 2004 Jan 15;10(2):508-20. doi: 10.1158/1078-0432.ccr-0755-03. PMID: 14760072
Detection of cytoplasmic and surface membrane markers in cells of some human hematopoietic cell lines.
Koníková E, Babusíková O, Kusenda J, Glasová M
Neoplasma 1992;39(6):337-42. PMID: 1491722

Prognosis

CD26 expression correlates with a reduced sensitivity to 2'-deoxycoformycin-induced growth inhibition and apoptosis in T-cell leukemia/lymphomas.
Aldinucci D, Poletto D, Lorenzon D, Nanni P, Degan M, Olivo K, Rapanà B, Pinto A, Gattei V
Clin Cancer Res 2004 Jan 15;10(2):508-20. doi: 10.1158/1078-0432.ccr-0755-03. PMID: 14760072
The expression of CD26 and CD40 ligand is mutually exclusive in human T-cell non-Hodgkin's lymphomas/leukemias.
Carbone A, Gloghini A, Zagonel V, Aldinucci D, Gattei V, Degan M, Improta S, Sorio R, Monfardini S, Pinto A
Blood 1995 Dec 15;86(12):4617-26. PMID: 8541553

Clinical prediction guides

CD26 expression correlates with a reduced sensitivity to 2'-deoxycoformycin-induced growth inhibition and apoptosis in T-cell leukemia/lymphomas.
Aldinucci D, Poletto D, Lorenzon D, Nanni P, Degan M, Olivo K, Rapanà B, Pinto A, Gattei V
Clin Cancer Res 2004 Jan 15;10(2):508-20. doi: 10.1158/1078-0432.ccr-0755-03. PMID: 14760072

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