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Hyperemesis gravidarum, susceptibility to(HG)

MedGen UID:
1054599
Concept ID:
CN376898
Disease or Syndrome
Synonym: HG
 
Gene (location): GDF15 (19p13.11)
 
Monarch Initiative: MONDO:0958238
OMIM®: 620730

Definition

Hyperemesis gravidarum (HG) is characterized by severe nausea and vomiting in pregnancy. It occurs in up to 2% of pregnancies and results in significant weight loss, dehydration, electrolyte imbalance, and ketonuria. It is associated with both maternal and fetal morbidity (Fejzo et al., 2019). [from OMIM]

Recent clinical studies

Therapy

Liu X, Zhou X, Wang J, Cai A, Zhang Y, Zhang J, Wu Z, Zhu B
J Matern Fetal Neonatal Med 2024 Dec;37(1):2397722. Epub 2024 Sep 16 doi: 10.1080/14767058.2024.2397722. PMID: 39284761
Fejzo MS, Romero R, Goodwin TM
Fertil Steril 2010 Jan;93(1):267.e9-11. Epub 2009 Oct 29 doi: 10.1016/j.fertnstert.2009.09.022. PMID: 19878938Free PMC Article

Prognosis

Liu X, Zhou X, Wang J, Cai A, Zhang Y, Zhang J, Wu Z, Zhu B
J Matern Fetal Neonatal Med 2024 Dec;37(1):2397722. Epub 2024 Sep 16 doi: 10.1080/14767058.2024.2397722. PMID: 39284761
Changalidis AI, Maksiutenko EM, Barbitoff YA, Tkachenko AA, Vashukova ES, Pachuliia OV, Nasykhova YA, Glotov AS
Genes (Basel) 2022 Nov 30;13(12) doi: 10.3390/genes13122255. PMID: 36553520Free PMC Article

Clinical prediction guides

Liu X, Zhou X, Wang J, Cai A, Zhang Y, Zhang J, Wu Z, Zhu B
J Matern Fetal Neonatal Med 2024 Dec;37(1):2397722. Epub 2024 Sep 16 doi: 10.1080/14767058.2024.2397722. PMID: 39284761
Changalidis AI, Maksiutenko EM, Barbitoff YA, Tkachenko AA, Vashukova ES, Pachuliia OV, Nasykhova YA, Glotov AS
Genes (Basel) 2022 Nov 30;13(12) doi: 10.3390/genes13122255. PMID: 36553520Free PMC Article
Black FO
Am J Obstet Gynecol 2002 May;186(5 Suppl Understanding):S204-9. doi: 10.1067/mob.2002.122602. PMID: 12011887

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