U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Pioglitazone response

MedGen UID:
1093607
•Concept ID:
CN427422
•
Sign or Symptom
Drug:
Pioglitazone
MedGen UID:
20220
•Concept ID:
C0071097
•
Pharmacologic Substance
An orally-active thiazolidinedione with antidiabetic properties and potential antineoplastic activity. Pioglitazone activates peroxisome proliferator-activated receptor gamma (PPAR-gamma), a ligand-activated transcription factor, thereby inducing cell differentiation and inhibiting cell growth and angiogenesis. This agent also modulates the transcription of insulin-responsive genes, inhibits macrophage and monocyte activation, and stimulates adipocyte differentiation. [from NCI]
Pioglitazone
 
Gene (location): CYP2C8 (10q23.33)

Professional guidelines

PubMed

Current treatment of non-alcoholic fatty liver disease.
Paternostro R, Trauner M
J Intern Med 2022 Aug;292(2):190-204. Epub 2022 Jul 7 doi: 10.1111/joim.13531. PMID: 35796150Free PMC Article
American Association of Clinical Endocrinology Clinical Practice Guideline for the Diagnosis and Management of Nonalcoholic Fatty Liver Disease in Primary Care and Endocrinology Clinical Settings: Co-Sponsored by the American Association for the Study of Liver Diseases (AASLD).
Cusi K, Isaacs S, Barb D, Basu R, Caprio S, Garvey WT, Kashyap S, Mechanick JI, Mouzaki M, Nadolsky K, Rinella ME, Vos MB, Younossi Z
Endocr Pract 2022 May;28(5):528-562. doi: 10.1016/j.eprac.2022.03.010. PMID: 35569886
Non-alcoholic fatty liver disease (NAFLD): a review of pathophysiology, clinical management and effects of weight loss.
Pouwels S, Sakran N, Graham Y, Leal A, Pintar T, Yang W, Kassir R, Singhal R, Mahawar K, Ramnarain D
BMC Endocr Disord 2022 Mar 14;22(1):63. doi: 10.1186/s12902-022-00980-1. PMID: 35287643Free PMC Article

Curated

DailyMed Drug Label, pioglitazone, 2021

DailyMed Drug Label, PIOGLITAZONE HYDROCHLORIDE, 2019

Recent clinical studies

Etiology

Factors associated with treatment responses to pioglitazone in patients with steatotic liver disease: A 3-year prospective cohort study.
Chang ML, Tai J, Cheng JS, Chen WT, Yang SS, Chiu CH, Chien RN
Diabetes Obes Metab 2024 Jul;26(7):2969-2978. Epub 2024 Apr 29 doi: 10.1111/dom.15622. PMID: 38685616
Polymorphism of peroxisome proliferator-activated receptor γ (PPARγ) Pro12Ala in the Iranian population: relation with insulin resistance and response to treatment with pioglitazone in type 2 diabetes.
Namvaran F, Azarpira N, Rahimi-Moghaddam P, Dabbaghmanesh MH
Eur J Pharmacol 2011 Dec 5;671(1-3):1-6. Epub 2011 Sep 24 doi: 10.1016/j.ejphar.2011.09.158. PMID: 21968139
Glimepiride versus pioglitazone combination therapy in subjects with type 2 diabetes inadequately controlled on metformin monotherapy: results of a randomized clinical trial.
Umpierrez G, Issa M, Vlajnic A
Curr Med Res Opin 2006 Apr;22(4):751-9. doi: 10.1185/030079906X104786. PMID: 16684436

Diagnosis

Polymorphism of peroxisome proliferator-activated receptor γ (PPARγ) Pro12Ala in the Iranian population: relation with insulin resistance and response to treatment with pioglitazone in type 2 diabetes.
Namvaran F, Azarpira N, Rahimi-Moghaddam P, Dabbaghmanesh MH
Eur J Pharmacol 2011 Dec 5;671(1-3):1-6. Epub 2011 Sep 24 doi: 10.1016/j.ejphar.2011.09.158. PMID: 21968139

Therapy

Factors associated with treatment responses to pioglitazone in patients with steatotic liver disease: A 3-year prospective cohort study.
Chang ML, Tai J, Cheng JS, Chen WT, Yang SS, Chiu CH, Chien RN
Diabetes Obes Metab 2024 Jul;26(7):2969-2978. Epub 2024 Apr 29 doi: 10.1111/dom.15622. PMID: 38685616
CYP2C8 and SLCO1B1 Variants and Therapeutic Response to Thiazolidinediones in Patients With Type 2 Diabetes.
Dawed AY, Donnelly L, Tavendale R, Carr F, Leese G, Palmer CN, Pearson ER, Zhou K
Diabetes Care 2016 Nov;39(11):1902-1908. Epub 2016 Jun 6 doi: 10.2337/dc15-2464. PMID: 27271184
The effect of IGF2BP2 gene polymorphisms on pioglitazone response in Chinese type 2 diabetes patients.
Zhang LF, Pei Q, Yang GP, Zhao YC, Mu YF, Huang Q, Zhu YL
Pharmacology 2014;94(3-4):115-22. Epub 2014 Sep 18 doi: 10.1159/000363414. PMID: 25247335
Polymorphism of peroxisome proliferator-activated receptor γ (PPARγ) Pro12Ala in the Iranian population: relation with insulin resistance and response to treatment with pioglitazone in type 2 diabetes.
Namvaran F, Azarpira N, Rahimi-Moghaddam P, Dabbaghmanesh MH
Eur J Pharmacol 2011 Dec 5;671(1-3):1-6. Epub 2011 Sep 24 doi: 10.1016/j.ejphar.2011.09.158. PMID: 21968139
Glimepiride versus pioglitazone combination therapy in subjects with type 2 diabetes inadequately controlled on metformin monotherapy: results of a randomized clinical trial.
Umpierrez G, Issa M, Vlajnic A
Curr Med Res Opin 2006 Apr;22(4):751-9. doi: 10.1185/030079906X104786. PMID: 16684436

Prognosis

Factors associated with treatment responses to pioglitazone in patients with steatotic liver disease: A 3-year prospective cohort study.
Chang ML, Tai J, Cheng JS, Chen WT, Yang SS, Chiu CH, Chien RN
Diabetes Obes Metab 2024 Jul;26(7):2969-2978. Epub 2024 Apr 29 doi: 10.1111/dom.15622. PMID: 38685616
Glimepiride versus pioglitazone combination therapy in subjects with type 2 diabetes inadequately controlled on metformin monotherapy: results of a randomized clinical trial.
Umpierrez G, Issa M, Vlajnic A
Curr Med Res Opin 2006 Apr;22(4):751-9. doi: 10.1185/030079906X104786. PMID: 16684436

Clinical prediction guides

Factors associated with treatment responses to pioglitazone in patients with steatotic liver disease: A 3-year prospective cohort study.
Chang ML, Tai J, Cheng JS, Chen WT, Yang SS, Chiu CH, Chien RN
Diabetes Obes Metab 2024 Jul;26(7):2969-2978. Epub 2024 Apr 29 doi: 10.1111/dom.15622. PMID: 38685616

Supplemental Content

Table of contents

    Genetic Testing Registry

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Curated

    Consumer resources

    Reviews

    Related information

    • Gene
      Related information in NCBI Gene
    • GTR
      Related information in GTR
    • GTR(Clinical)
      Clinical tests in GTR
    • OMIM(Genes)
      OMIM records containing genes associated with phenotypes registered in MedGen
    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...