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Fatty liver disease, protection from(FLDP)

MedGen UID:
1824027
•Concept ID:
C5774254
•
Finding
Synonym: FLDP
 
Gene (location): HSD17B13 (4q22.1)
 
OMIM®: 620116

Definition

Chronic liver disease, including alcoholic and nonalcoholic fatty liver disease, can progress to cirrhosis in some individuals. Patients with FLDP show protection against the progression to chronic liver disease from simple steatosis (summary by Abul-Husn et al., 2018). [from OMIM]

Professional guidelines

PubMed

Diagnosis and Management of Cirrhosis and Its Complications: A Review.
Tapper EB, Parikh ND
JAMA 2023 May 9;329(18):1589-1602. doi: 10.1001/jama.2023.5997. PMID: 37159031Free PMC Article
Non-alcoholic fatty liver disease (NAFLD): a review of pathophysiology, clinical management and effects of weight loss.
Pouwels S, Sakran N, Graham Y, Leal A, Pintar T, Yang W, Kassir R, Singhal R, Mahawar K, Ramnarain D
BMC Endocr Disord 2022 Mar 14;22(1):63. doi: 10.1186/s12902-022-00980-1. PMID: 35287643Free PMC Article
ACG Clinical Guideline: Evaluation of Abnormal Liver Chemistries.
Kwo PY, Cohen SM, Lim JK
Am J Gastroenterol 2017 Jan;112(1):18-35. Epub 2016 Dec 20 doi: 10.1038/ajg.2016.517. PMID: 27995906

Recent clinical studies

Etiology

Treatments for NAFLD: State of Art.
Mantovani A, Dalbeni A
Int J Mol Sci 2021 Feb 26;22(5) doi: 10.3390/ijms22052350. PMID: 33652942Free PMC Article
Diet and Non-Alcoholic Fatty Liver Disease: The Mediterranean Way.
Abenavoli L, Boccuto L, Federico A, Dallio M, Loguercio C, Di Renzo L, De Lorenzo A
Int J Environ Res Public Health 2019 Aug 21;16(17) doi: 10.3390/ijerph16173011. PMID: 31438482Free PMC Article
Non-alcoholic fatty liver disease: causes, diagnosis, cardiometabolic consequences, and treatment strategies.
Stefan N, Häring HU, Cusi K
Lancet Diabetes Endocrinol 2019 Apr;7(4):313-324. Epub 2018 Aug 30 doi: 10.1016/S2213-8587(18)30154-2. PMID: 30174213
Treatment options for alcoholic and non-alcoholic fatty liver disease: A review.
Singh S, Osna NA, Kharbanda KK
World J Gastroenterol 2017 Sep 28;23(36):6549-6570. doi: 10.3748/wjg.v23.i36.6549. PMID: 29085205Free PMC Article
Nonalcoholic fatty liver disease: a systematic review.
Rinella ME
JAMA 2015 Jun 9;313(22):2263-73. doi: 10.1001/jama.2015.5370. PMID: 26057287

Diagnosis

Mitochondrial pyruvate carrier 1 regulates fatty acid synthase lactylation and mediates treatment of nonalcoholic fatty liver disease.
Gao R, Li Y, Xu Z, Zhang F, Xu J, Hu Y, Yin J, Yang K, Sun L, Wang Q, He X, Huang K
Hepatology 2023 Dec 1;78(6):1800-1815. Epub 2023 Jan 19 doi: 10.1097/HEP.0000000000000279. PMID: 36651176
Non-alcoholic fatty liver disease (NAFLD): a review of pathophysiology, clinical management and effects of weight loss.
Pouwels S, Sakran N, Graham Y, Leal A, Pintar T, Yang W, Kassir R, Singhal R, Mahawar K, Ramnarain D
BMC Endocr Disord 2022 Mar 14;22(1):63. doi: 10.1186/s12902-022-00980-1. PMID: 35287643Free PMC Article
Nonalcoholic Fatty Liver Disease and Obesity Treatment.
Brunner KT, Henneberg CJ, Wilechansky RM, Long MT
Curr Obes Rep 2019 Sep;8(3):220-228. doi: 10.1007/s13679-019-00345-1. PMID: 30945129Free PMC Article
Non-alcoholic fatty liver disease: causes, diagnosis, cardiometabolic consequences, and treatment strategies.
Stefan N, Häring HU, Cusi K
Lancet Diabetes Endocrinol 2019 Apr;7(4):313-324. Epub 2018 Aug 30 doi: 10.1016/S2213-8587(18)30154-2. PMID: 30174213
Nonalcoholic fatty liver disease: a systematic review.
Rinella ME
JAMA 2015 Jun 9;313(22):2263-73. doi: 10.1001/jama.2015.5370. PMID: 26057287

Therapy

Non-alcoholic fatty liver disease (NAFLD): a review of pathophysiology, clinical management and effects of weight loss.
Pouwels S, Sakran N, Graham Y, Leal A, Pintar T, Yang W, Kassir R, Singhal R, Mahawar K, Ramnarain D
BMC Endocr Disord 2022 Mar 14;22(1):63. doi: 10.1186/s12902-022-00980-1. PMID: 35287643Free PMC Article
Treatments for NAFLD: State of Art.
Mantovani A, Dalbeni A
Int J Mol Sci 2021 Feb 26;22(5) doi: 10.3390/ijms22052350. PMID: 33652942Free PMC Article
Cordycepin Ameliorates Nonalcoholic Steatohepatitis by Activation of the AMP-Activated Protein Kinase Signaling Pathway.
Lan T, Yu Y, Zhang J, Li H, Weng Q, Jiang S, Tian S, Xu T, Hu S, Yang G, Zhang Y, Wang W, Wang L, Zhu Q, Rong X, Guo J
Hepatology 2021 Aug;74(2):686-703. doi: 10.1002/hep.31749. PMID: 33576035Free PMC Article
Silymarin as Supportive Treatment in Liver Diseases: A Narrative Review.
Gillessen A, Schmidt HH
Adv Ther 2020 Apr;37(4):1279-1301. Epub 2020 Feb 17 doi: 10.1007/s12325-020-01251-y. PMID: 32065376Free PMC Article
Nonalcoholic fatty liver disease: a systematic review.
Rinella ME
JAMA 2015 Jun 9;313(22):2263-73. doi: 10.1001/jama.2015.5370. PMID: 26057287

Prognosis

Multiomics study of nonalcoholic fatty liver disease.
Sveinbjornsson G, Ulfarsson MO, Thorolfsdottir RB, Jonsson BA, Einarsson E, Gunnlaugsson G, Rognvaldsson S, Arnar DO, Baldvinsson M, Bjarnason RG; DBDS Genomic consortium, Eiriksdottir T, Erikstrup C, Ferkingstad E, Halldorsson GH, Helgason H, Helgadottir A, Hindhede L, Hjorleifsson G, Jones D, Knowlton KU, Lund SH, Melsted P, Norland K, Olafsson I, Olafsson S, Oskarsson GR, Ostrowski SR, Pedersen OB, Snaebjarnarson AS, Sigurdsson E, Steinthorsdottir V, Schwinn M, Thorgeirsson G, Thorleifsson G, Jonsdottir I, Bundgaard H, Nadauld L, Bjornsson ES, Rulifson IC, Rafnar T, Norddahl GL, Thorsteinsdottir U, Sulem P, Gudbjartsson DF, Holm H, Stefansson K
Nat Genet 2022 Nov;54(11):1652-1663. Epub 2022 Oct 24 doi: 10.1038/s41588-022-01199-5. PMID: 36280732Free PMC Article
Non-alcoholic fatty liver disease (NAFLD): a review of pathophysiology, clinical management and effects of weight loss.
Pouwels S, Sakran N, Graham Y, Leal A, Pintar T, Yang W, Kassir R, Singhal R, Mahawar K, Ramnarain D
BMC Endocr Disord 2022 Mar 14;22(1):63. doi: 10.1186/s12902-022-00980-1. PMID: 35287643Free PMC Article
Gut microbiota and its mysteries.
Pushpanathan P, Mathew GS, Selvarajan S, Seshadri KG, Srikanth P
Indian J Med Microbiol 2019 Apr-Jun;37(2):268-277. doi: 10.4103/ijmm.IJMM_19_373. PMID: 31745030
Non-alcoholic fatty liver disease: causes, diagnosis, cardiometabolic consequences, and treatment strategies.
Stefan N, Häring HU, Cusi K
Lancet Diabetes Endocrinol 2019 Apr;7(4):313-324. Epub 2018 Aug 30 doi: 10.1016/S2213-8587(18)30154-2. PMID: 30174213
Nonalcoholic fatty liver disease: a systematic review.
Rinella ME
JAMA 2015 Jun 9;313(22):2263-73. doi: 10.1001/jama.2015.5370. PMID: 26057287

Clinical prediction guides

Non-alcoholic fatty liver disease (NAFLD): a review of pathophysiology, clinical management and effects of weight loss.
Pouwels S, Sakran N, Graham Y, Leal A, Pintar T, Yang W, Kassir R, Singhal R, Mahawar K, Ramnarain D
BMC Endocr Disord 2022 Mar 14;22(1):63. doi: 10.1186/s12902-022-00980-1. PMID: 35287643Free PMC Article
Silymarin as Supportive Treatment in Liver Diseases: A Narrative Review.
Gillessen A, Schmidt HH
Adv Ther 2020 Apr;37(4):1279-1301. Epub 2020 Feb 17 doi: 10.1007/s12325-020-01251-y. PMID: 32065376Free PMC Article
Nonalcoholic Fatty Liver Disease and Obesity Treatment.
Brunner KT, Henneberg CJ, Wilechansky RM, Long MT
Curr Obes Rep 2019 Sep;8(3):220-228. doi: 10.1007/s13679-019-00345-1. PMID: 30945129Free PMC Article
Preclinical models of non-alcoholic fatty liver disease.
Santhekadur PK, Kumar DP, Sanyal AJ
J Hepatol 2018 Feb;68(2):230-237. Epub 2017 Nov 9 doi: 10.1016/j.jhep.2017.10.031. PMID: 29128391Free PMC Article
Nonalcoholic fatty liver disease: a systematic review.
Rinella ME
JAMA 2015 Jun 9;313(22):2263-73. doi: 10.1001/jama.2015.5370. PMID: 26057287

Recent systematic reviews

Treatment of periodontitis for glycaemic control in people with diabetes mellitus.
Simpson TC, Clarkson JE, Worthington HV, MacDonald L, Weldon JC, Needleman I, Iheozor-Ejiofor Z, Wild SH, Qureshi A, Walker A, Patel VA, Boyers D, Twigg J
Cochrane Database Syst Rev 2022 Apr 14;4(4):CD004714. doi: 10.1002/14651858.CD004714.pub4. PMID: 35420698Free PMC Article
Regulation of Intestinal Inflammation by Dietary Fats.
Basson AR, Chen C, Sagl F, Trotter A, Bederman I, Gomez-Nguyen A, Sundrud MS, Ilic S, Cominelli F, Rodriguez-Palacios A
Front Immunol 2020;11:604989. Epub 2021 Feb 2 doi: 10.3389/fimmu.2020.604989. PMID: 33603741Free PMC Article
Silymarin as Supportive Treatment in Liver Diseases: A Narrative Review.
Gillessen A, Schmidt HH
Adv Ther 2020 Apr;37(4):1279-1301. Epub 2020 Feb 17 doi: 10.1007/s12325-020-01251-y. PMID: 32065376Free PMC Article
Current guidelines for the management of non-alcoholic fatty liver disease: A systematic review with comparative analysis.
Leoni S, Tovoli F, Napoli L, Serio I, Ferri S, Bolondi L
World J Gastroenterol 2018 Aug 14;24(30):3361-3373. doi: 10.3748/wjg.v24.i30.3361. PMID: 30122876Free PMC Article
Nonalcoholic fatty liver disease: a systematic review.
Rinella ME
JAMA 2015 Jun 9;313(22):2263-73. doi: 10.1001/jama.2015.5370. PMID: 26057287

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