U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from Gene

Hyperemesis gravidarum, susceptibility to(HG)

MedGen UID:
1054599
•Concept ID:
CN376898
•
Disease or Syndrome
Synonym: HG
 
Gene (location): GDF15 (19p13.11)
 
Monarch Initiative: MONDO:0958238
OMIM®: 620730

Definition

Hyperemesis gravidarum (HG) is characterized by severe nausea and vomiting in pregnancy. It occurs in up to 2% of pregnancies and results in significant weight loss, dehydration, electrolyte imbalance, and ketonuria. It is associated with both maternal and fetal morbidity (Fejzo et al., 2019). [from OMIM]

Recent clinical studies

Etiology

GDF15 linked to maternal risk of nausea and vomiting during pregnancy.
Fejzo M, Rocha N, Cimino I, Lockhart SM, Petry CJ, Kay RG, Burling K, Barker P, George AL, Yasara N, Premawardhena A, Gong S, Cook E, Rimmington D, Rainbow K, Withers DJ, Cortessis V, Mullin PM, MacGibbon KW, Jin E, Kam A, Campbell A, Polasek O, Tzoneva G, Gribble FM, Yeo GSH, Lam BYH, Saudek V, Hughes IA, Ong KK, Perry JRB, Sutton Cole A, Baumgarten M, Welsh P, Sattar N, Smith GCS, Charnock-Jones DS, Coll AP, Meek CL, Mettananda S, Hayward C, Mancuso N, O'Rahilly S
Nature 2024 Jan;625(7996):760-767. Epub 2023 Dec 13 doi: 10.1038/s41586-023-06921-9. PMID: 38092039Free PMC Article
Aggregation of Genome-Wide Association Data from FinnGen and UK Biobank Replicates Multiple Risk Loci for Pregnancy Complications.
Changalidis AI, Maksiutenko EM, Barbitoff YA, Tkachenko AA, Vashukova ES, Pachuliia OV, Nasykhova YA, Glotov AS
Genes (Basel) 2022 Nov 30;13(12) doi: 10.3390/genes13122255. PMID: 36553520Free PMC Article
Hyperemesis gravidarum and long-term health of the offspring.
Ayyavoo A, Derraik JG, Hofman PL, Cutfield WS
Am J Obstet Gynecol 2014 Jun;210(6):521-5. Epub 2013 Nov 23 doi: 10.1016/j.ajog.2013.11.035. PMID: 24280249
Pregnancy outcome in hyperemesis gravidarum--the role of fetal gender.
Peled Y, Melamed N, Hiersch L, Hadar E, Wiznitzer A, Yogev Y
J Matern Fetal Neonatal Med 2013 Nov;26(17):1753-7. Epub 2013 May 24 doi: 10.3109/14767058.2013.798293. PMID: 23611752
Familial aggregation of hyperemesis gravidarum.
Zhang Y, Cantor RM, MacGibbon K, Romero R, Goodwin TM, Mullin PM, Fejzo MS
Am J Obstet Gynecol 2011 Mar;204(3):230.e1-7. Epub 2010 Oct 25 doi: 10.1016/j.ajog.2010.09.018. PMID: 20974461Free PMC Article

Diagnosis

GDF15 linked to maternal risk of nausea and vomiting during pregnancy.
Fejzo M, Rocha N, Cimino I, Lockhart SM, Petry CJ, Kay RG, Burling K, Barker P, George AL, Yasara N, Premawardhena A, Gong S, Cook E, Rimmington D, Rainbow K, Withers DJ, Cortessis V, Mullin PM, MacGibbon KW, Jin E, Kam A, Campbell A, Polasek O, Tzoneva G, Gribble FM, Yeo GSH, Lam BYH, Saudek V, Hughes IA, Ong KK, Perry JRB, Sutton Cole A, Baumgarten M, Welsh P, Sattar N, Smith GCS, Charnock-Jones DS, Coll AP, Meek CL, Mettananda S, Hayward C, Mancuso N, O'Rahilly S
Nature 2024 Jan;625(7996):760-767. Epub 2023 Dec 13 doi: 10.1038/s41586-023-06921-9. PMID: 38092039Free PMC Article
Hyperemesis gravidarum and long-term health of the offspring.
Ayyavoo A, Derraik JG, Hofman PL, Cutfield WS
Am J Obstet Gynecol 2014 Jun;210(6):521-5. Epub 2013 Nov 23 doi: 10.1016/j.ajog.2013.11.035. PMID: 24280249
Pregnancy outcome in hyperemesis gravidarum--the role of fetal gender.
Peled Y, Melamed N, Hiersch L, Hadar E, Wiznitzer A, Yogev Y
J Matern Fetal Neonatal Med 2013 Nov;26(17):1753-7. Epub 2013 May 24 doi: 10.3109/14767058.2013.798293. PMID: 23611752

Therapy

Patients with a history of hyperemesis gravidarum have similar symptoms during egg stimulation and develop ovarian hyperstimulation syndrome: case series.
Fejzo MS, Romero R, Goodwin TM
Fertil Steril 2010 Jan;93(1):267.e9-11. Epub 2009 Oct 29 doi: 10.1016/j.fertnstert.2009.09.022. PMID: 19878938Free PMC Article

Prognosis

Aggregation of Genome-Wide Association Data from FinnGen and UK Biobank Replicates Multiple Risk Loci for Pregnancy Complications.
Changalidis AI, Maksiutenko EM, Barbitoff YA, Tkachenko AA, Vashukova ES, Pachuliia OV, Nasykhova YA, Glotov AS
Genes (Basel) 2022 Nov 30;13(12) doi: 10.3390/genes13122255. PMID: 36553520Free PMC Article

Clinical prediction guides

Aggregation of Genome-Wide Association Data from FinnGen and UK Biobank Replicates Multiple Risk Loci for Pregnancy Complications.
Changalidis AI, Maksiutenko EM, Barbitoff YA, Tkachenko AA, Vashukova ES, Pachuliia OV, Nasykhova YA, Glotov AS
Genes (Basel) 2022 Nov 30;13(12) doi: 10.3390/genes13122255. PMID: 36553520Free PMC Article
Maternal susceptibility to nausea and vomiting of pregnancy: is the vestibular system involved?
Black FO
Am J Obstet Gynecol 2002 May;186(5 Suppl Understanding):S204-9. doi: 10.1067/mob.2002.122602. PMID: 12011887

Supplemental Content

Table of contents

    Clinical resources

    Consumer resources

    Reviews

    Related information

    • ClinVar
      Related medical variations
    • Gene
      Related information in NCBI Gene
    • OMIM
      Related records in OMIM
    • OMIM(Genes)
      OMIM records containing genes associated with phenotypes registered in MedGen
    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...