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T-CELL LEUKEMIA/LYMPHOMA 1A

MedGen UID:
444029
•Concept ID:
C2931321
•
Neoplastic Process
Synonym: T-cell lymphoma 1A
 
Cytogenetic location: 14q32.13
 
OMIM®: 186960

Professional guidelines

PubMed

Treatment outcomes of childhood PICALM::MLLT10 acute leukaemias.
Mark C, Meshinchi S, Joyce B, Gibson B, Harrison C, Bergmann AK, Goemans BF, Pronk CJH, Lapillonne H, Leverger G, Antoniou E, Schneider M, Attarbaschi A, Dworzak M, Stary J, Tomizawa D, Ebert S, Lejman M, Kolb EA, Schmiegelow K, Hasle H, Abla O
Br J Haematol 2024 Feb;204(2):576-584. Epub 2023 Sep 24 doi: 10.1111/bjh.19067. PMID: 37743097
Inhibition of the NOTCH and mTOR pathways by nelfinavir as a novel treatment for T cell acute lymphoblastic leukemia.
Chang YS, Gills JJ, Kawabata S, Onozawa M, Della Gatta G, Ferrando AA, Aplan PD, Dennis PA
Int J Oncol 2023 Nov;63(5) Epub 2023 Oct 6 doi: 10.3892/ijo.2023.5576. PMID: 37800623Free PMC Article
Pharmacologic interception in T-cell leukemia 1A associated pathways as a treatment rationale for chronic lymphocytic leukemia.
Popal W, Boucas J, Peer-Zada AA, Herling M
Leuk Lymphoma 2010 Aug;51(8):1375-8. doi: 10.3109/10428194.2010.505064. PMID: 20687795

Recent clinical studies

Etiology

Comparative transcriptome analysis of peripheral blood mononuclear cells in renal transplant recipients in everolimus- and tacrolimus-based immunosuppressive therapy.
Granata S, Santoro G, Signorini L, Malerba G, Patuzzo C, Gambaro G, Stallone G, Zaza G
Eur J Pharmacol 2019 Sep 15;859:172494. Epub 2019 Jun 22 doi: 10.1016/j.ejphar.2019.172494. PMID: 31238062
Genomic profiling reveals the potential role of TCL1A and MDR1 deficiency in chemotherapy-induced cardiotoxicity.
McCaffrey TA, Tziros C, Lewis J, Katz R, Siegel R, Weglicki W, Kramer J, Mak IT, Toma I, Chen L, Benas E, Lowitt A, Rao S, Witkin L, Lian Y, Lai Y, Yang Z, Fu SW
Int J Biol Sci 2013;9(4):350-60. Epub 2013 Apr 22 doi: 10.7150/ijbs.6058. PMID: 23630447Free PMC Article

Diagnosis

T-cell lymphoblastic leukemia/lymphoma with t(7;14)(p15;q32) [TCRγ-TCL1A translocation]: a case report and a review of the literature.
Sugimoto KJ, Shimada A, Wakabayashi M, Sekiguchi Y, Izumi H, Ota Y, Komatsu N, Noguchi M
Int J Clin Exp Pathol 2014;7(5):2615-23. Epub 2014 Apr 15 PMID: 24966976Free PMC Article
Genomic profiling reveals the potential role of TCL1A and MDR1 deficiency in chemotherapy-induced cardiotoxicity.
McCaffrey TA, Tziros C, Lewis J, Katz R, Siegel R, Weglicki W, Kramer J, Mak IT, Toma I, Chen L, Benas E, Lowitt A, Rao S, Witkin L, Lian Y, Lai Y, Yang Z, Fu SW
Int J Biol Sci 2013;9(4):350-60. Epub 2013 Apr 22 doi: 10.7150/ijbs.6058. PMID: 23630447Free PMC Article
Identification of TCL1A as an immunohistochemical marker of adverse outcome in diffuse large B-cell lymphomas.
Ramuz O, Bouabdallah R, Devilard E, Borie N, Groulet-Martinec A, Bardou VJ, Brousset P, Bertucci F, Birg F, Birnbaum D, Xerri L
Int J Oncol 2005 Jan;26(1):151-7. PMID: 15586235

Therapy

Comparative transcriptome analysis of peripheral blood mononuclear cells in renal transplant recipients in everolimus- and tacrolimus-based immunosuppressive therapy.
Granata S, Santoro G, Signorini L, Malerba G, Patuzzo C, Gambaro G, Stallone G, Zaza G
Eur J Pharmacol 2019 Sep 15;859:172494. Epub 2019 Jun 22 doi: 10.1016/j.ejphar.2019.172494. PMID: 31238062
Genomic profiling reveals the potential role of TCL1A and MDR1 deficiency in chemotherapy-induced cardiotoxicity.
McCaffrey TA, Tziros C, Lewis J, Katz R, Siegel R, Weglicki W, Kramer J, Mak IT, Toma I, Chen L, Benas E, Lowitt A, Rao S, Witkin L, Lian Y, Lai Y, Yang Z, Fu SW
Int J Biol Sci 2013;9(4):350-60. Epub 2013 Apr 22 doi: 10.7150/ijbs.6058. PMID: 23630447Free PMC Article

Prognosis

T-cell leukemia/lymphoma-1A predicts the clinical outcome for patients with stage II/III colorectal cancer.
Li H, Yan X, Liu L, Huang L, Yin M, Pan C, Zhang P, Qin H
Biomed Pharmacother 2017 Apr;88:924-930. Epub 2017 Feb 6 doi: 10.1016/j.biopha.2017.01.128. PMID: 28178623
The regulatory interaction of EVI1 with the TCL1A oncogene impacts cell survival and clinical outcome in CLL.
Vasyutina E, Boucas JM, Bloehdorn J, Aszyk C, Crispatzu G, Stiefelhagen M, Breuer A, Mayer P, Lengerke C, Döhner H, Beutner D, Rosenwald A, Stilgenbauer S, Hallek M, Benner A, Herling M
Leukemia 2015 Oct;29(10):2003-14. Epub 2015 May 4 doi: 10.1038/leu.2015.114. PMID: 25936528
TCL1A expression delineates biological and clinical variability in B-cell lymphoma.
Aggarwal M, Villuendas R, Gomez G, Rodriguez-Pinilla SM, Sanchez-Beato M, Alvarez D, Martinez N, Rodriguez A, Castillo ME, Camacho FI, Montes-Moreno S, Garcia-Marco JA, Kimby E, Pisano DG, Piris MA
Mod Pathol 2009 Feb;22(2):206-15. Epub 2008 Sep 26 doi: 10.1038/modpathol.2008.148. PMID: 18820675
Identification of TCL1A as an immunohistochemical marker of adverse outcome in diffuse large B-cell lymphomas.
Ramuz O, Bouabdallah R, Devilard E, Borie N, Groulet-Martinec A, Bardou VJ, Brousset P, Bertucci F, Birg F, Birnbaum D, Xerri L
Int J Oncol 2005 Jan;26(1):151-7. PMID: 15586235

Clinical prediction guides

T-cell leukemia/lymphoma-1A predicts the clinical outcome for patients with stage II/III colorectal cancer.
Li H, Yan X, Liu L, Huang L, Yin M, Pan C, Zhang P, Qin H
Biomed Pharmacother 2017 Apr;88:924-930. Epub 2017 Feb 6 doi: 10.1016/j.biopha.2017.01.128. PMID: 28178623
Estrogen, SNP-Dependent Chemokine Expression and Selective Estrogen Receptor Modulator Regulation.
Ho MF, Bongartz T, Liu M, Kalari KR, Goss PE, Shepherd LE, Goetz MP, Kubo M, Ingle JN, Wang L, Weinshilboum RM
Mol Endocrinol 2016 Mar;30(3):382-98. Epub 2016 Feb 11 doi: 10.1210/me.2015-1267. PMID: 26866883Free PMC Article
The regulatory interaction of EVI1 with the TCL1A oncogene impacts cell survival and clinical outcome in CLL.
Vasyutina E, Boucas JM, Bloehdorn J, Aszyk C, Crispatzu G, Stiefelhagen M, Breuer A, Mayer P, Lengerke C, Döhner H, Beutner D, Rosenwald A, Stilgenbauer S, Hallek M, Benner A, Herling M
Leukemia 2015 Oct;29(10):2003-14. Epub 2015 May 4 doi: 10.1038/leu.2015.114. PMID: 25936528
Identification of TCL1A as an immunohistochemical marker of adverse outcome in diffuse large B-cell lymphomas.
Ramuz O, Bouabdallah R, Devilard E, Borie N, Groulet-Martinec A, Bardou VJ, Brousset P, Bertucci F, Birg F, Birnbaum D, Xerri L
Int J Oncol 2005 Jan;26(1):151-7. PMID: 15586235

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