U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from PMC

Heparin-induced thrombocytopenia(HIT)

MedGen UID:
124423
•Concept ID:
C0272285
•
Disease or Syndrome
Synonym: HIT
SNOMED CT: Heparin-induced thrombocytopenia (73397007); Heparin induced thrombocytopenia (73397007)
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
•Concept ID:
CN307044
•
Finding
Source: Orphanet
clinical entity without genetic inheritance.
See: This record
Not genetically inherited (Orphanet)
 
HPO: HP:0011874
Monarch Initiative: MONDO:0018048
Orphanet: ORPHA3325

Definition

Low platelet count following administration of unfractionated or (less commonly) low-molecular weight heparin. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVHeparin-induced thrombocytopenia
Follow this link to review classifications for Heparin-induced thrombocytopenia in Orphanet.

Professional guidelines

PubMed

Thrombocytopenia: Evaluation and Management.
Gauer RL, Whitaker DJ
Am Fam Physician 2022 Sep;106(3):288-298. PMID: 36126009
Heparin-induced thrombocytopenia: pathophysiology, diagnosis and treatment.
Hvas AM, Favaloro EJ, Hellfritzsch M
Expert Rev Hematol 2021 Apr;14(4):335-346. Epub 2021 Mar 30 doi: 10.1080/17474086.2021.1905512. PMID: 33736552
Heparin-induced thrombocytopenia (HIT): Review of incidence, diagnosis, and management.
Hogan M, Berger JS
Vasc Med 2020 Apr;25(2):160-173. Epub 2020 Mar 20 doi: 10.1177/1358863X19898253. PMID: 32195628

Recent clinical studies

Etiology

Thrombocytopenia: Evaluation and Management.
Gauer RL, Whitaker DJ
Am Fam Physician 2022 Sep;106(3):288-298. PMID: 36126009
Heparin-induced thrombocytopenia (HIT): Review of incidence, diagnosis, and management.
Hogan M, Berger JS
Vasc Med 2020 Apr;25(2):160-173. Epub 2020 Mar 20 doi: 10.1177/1358863X19898253. PMID: 32195628
Heparin-Induced Thrombocytopenia.
Frazer CA
J Infus Nurs 2017 Mar/Apr;40(2):98-100. doi: 10.1097/NAN.0000000000000215. PMID: 28248809
Heparin-induced thrombocytopenia.
Lovecchio F
Clin Toxicol (Phila) 2014 Jul;52(6):579-83. Epub 2014 May 20 doi: 10.3109/15563650.2014.917181. PMID: 24844576
Heparin-induced thrombocytopenia.
Bambrah RK, Pham DC, Zaiden R, Vu H, Tai S
Clin Adv Hematol Oncol 2011 Aug;9(8):594-9. PMID: 22236986

Diagnosis

Heparin-induced thrombocytopenia: pathophysiology, diagnosis and treatment.
Hvas AM, Favaloro EJ, Hellfritzsch M
Expert Rev Hematol 2021 Apr;14(4):335-346. Epub 2021 Mar 30 doi: 10.1080/17474086.2021.1905512. PMID: 33736552
Heparin-induced thrombocytopenia (HIT): Review of incidence, diagnosis, and management.
Hogan M, Berger JS
Vasc Med 2020 Apr;25(2):160-173. Epub 2020 Mar 20 doi: 10.1177/1358863X19898253. PMID: 32195628
How Can I Manage Thrombocytopenia in Hemodialysis Patient? A Review.
Guo Q, Lou Y, Liu L, Luo P
Ther Apher Dial 2020 Aug;24(4):352-360. Epub 2019 Dec 2 doi: 10.1111/1744-9987.13448. PMID: 31661590
Thrombocytopenia.
Lee EJ, Lee AI
Prim Care 2016 Dec;43(4):543-557. doi: 10.1016/j.pop.2016.07.008. PMID: 27866576
Heparin-induced thrombocytopenia.
Lovecchio F
Clin Toxicol (Phila) 2014 Jul;52(6):579-83. Epub 2014 May 20 doi: 10.3109/15563650.2014.917181. PMID: 24844576

Therapy

An Update on the Pathogenesis of COVID-19 and the Reportedly Rare Thrombotic Events Following Vaccination.
Kantarcioglu B, Iqbal O, Walenga JM, Lewis B, Lewis J, Carter CA, Singh M, Lievano F, Tafur A, Ramacciotti E, Gerotziafas GT, Jeske W, Fareed J
Clin Appl Thromb Hemost 2021 Jan-Dec;27:10760296211021498. doi: 10.1177/10760296211021498. PMID: 34060379Free PMC Article
Heparin-induced thrombocytopenia.
Jevtic SD, Morris AM, Warkentin TE, Pai M
CMAJ 2021 May 17;193(20):E736. Epub 2021 Apr 27 doi: 10.1503/cmaj.210637. PMID: 33906965Free PMC Article
Heparin-induced thrombocytopenia: pathophysiology, diagnosis and treatment.
Hvas AM, Favaloro EJ, Hellfritzsch M
Expert Rev Hematol 2021 Apr;14(4):335-346. Epub 2021 Mar 30 doi: 10.1080/17474086.2021.1905512. PMID: 33736552
Heparin-induced thrombocytopenia (HIT): Review of incidence, diagnosis, and management.
Hogan M, Berger JS
Vasc Med 2020 Apr;25(2):160-173. Epub 2020 Mar 20 doi: 10.1177/1358863X19898253. PMID: 32195628
Heparin-induced thrombocytopenia.
Lovecchio F
Clin Toxicol (Phila) 2014 Jul;52(6):579-83. Epub 2014 May 20 doi: 10.3109/15563650.2014.917181. PMID: 24844576

Prognosis

Thrombotic Thrombocytopenia after ChAdOx1 nCov-19 Vaccination.
Greinacher A, Thiele T, Warkentin TE, Weisser K, Kyrle PA, Eichinger S
N Engl J Med 2021 Jun 3;384(22):2092-2101. Epub 2021 Apr 9 doi: 10.1056/NEJMoa2104840. PMID: 33835769Free PMC Article
Thrombosis and Thrombocytopenia after ChAdOx1 nCoV-19 Vaccination.
Schultz NH, Sørvoll IH, Michelsen AE, Munthe LA, Lund-Johansen F, Ahlen MT, Wiedmann M, Aamodt AH, Skattør TH, Tjønnfjord GE, Holme PA
N Engl J Med 2021 Jun 3;384(22):2124-2130. Epub 2021 Apr 9 doi: 10.1056/NEJMoa2104882. PMID: 33835768Free PMC Article
Heparin-induced thrombocytopenia (HIT): Review of incidence, diagnosis, and management.
Hogan M, Berger JS
Vasc Med 2020 Apr;25(2):160-173. Epub 2020 Mar 20 doi: 10.1177/1358863X19898253. PMID: 32195628
Heparin-induced thrombocytopenia.
Greinacher A, Fürll B, Selleng S
Methods Mol Biol 2013;992:301-18. doi: 10.1007/978-1-62703-339-8_23. PMID: 23546723
Heparin-induced thrombocytopenia.
Greinacher A
J Thromb Haemost 2009 Jul;7 Suppl 1:9-12. doi: 10.1111/j.1538-7836.2009.03385.x. PMID: 19630757

Clinical prediction guides

Heparin-induced thrombocytopenia: pathophysiology, diagnosis and treatment.
Hvas AM, Favaloro EJ, Hellfritzsch M
Expert Rev Hematol 2021 Apr;14(4):335-346. Epub 2021 Mar 30 doi: 10.1080/17474086.2021.1905512. PMID: 33736552
Pathogenesis of heparin-induced thrombocytopenia.
Arepally GM, Cines DB
Transl Res 2020 Nov;225:131-140. Epub 2020 May 15 doi: 10.1016/j.trsl.2020.04.014. PMID: 32417430Free PMC Article
Heparin-induced thrombocytopenia (HIT): Review of incidence, diagnosis, and management.
Hogan M, Berger JS
Vasc Med 2020 Apr;25(2):160-173. Epub 2020 Mar 20 doi: 10.1177/1358863X19898253. PMID: 32195628
Drug-associated thrombocytopenia.
Bakchoul T, Marini I
Hematology Am Soc Hematol Educ Program 2018 Nov 30;2018(1):576-583. doi: 10.1182/asheducation-2018.1.576. PMID: 30504360Free PMC Article
American Society of Hematology 2018 guidelines for management of venous thromboembolism: heparin-induced thrombocytopenia.
Cuker A, Arepally GM, Chong BH, Cines DB, Greinacher A, Gruel Y, Linkins LA, Rodner SB, Selleng S, Warkentin TE, Wex A, Mustafa RA, Morgan RL, Santesso N
Blood Adv 2018 Nov 27;2(22):3360-3392. doi: 10.1182/bloodadvances.2018024489. PMID: 30482768Free PMC Article

Recent systematic reviews

Cardiac transplantation after heparin-induced thrombocytopenia: A systematic review.
Jimenez DC, Warner ED, Ahmad D, Rosen JL, Al-Rawas N, Morris RJ, Alvarez R, Rame JE, Entwistle JW, Massey HT, Tchantchaleishvili V
Clin Transplant 2022 Feb;36(2):e14567. Epub 2022 Jan 6 doi: 10.1111/ctr.14567. PMID: 34927287
COVID-19 Vaccine-Related Thrombosis: A Systematic Review and Exploratory Analysis.
Bilotta C, Perrone G, Adelfio V, Spatola GF, Uzzo ML, Argo A, Zerbo S
Front Immunol 2021;12:729251. Epub 2021 Nov 29 doi: 10.3389/fimmu.2021.729251. PMID: 34912330Free PMC Article
Comparative effectiveness and safety of anticoagulants for the treatment of heparin-induced thrombocytopenia.
Nilius H, Kaufmann J, Cuker A, Nagler M
Am J Hematol 2021 Jul 1;96(7):805-815. Epub 2021 May 3 doi: 10.1002/ajh.26194. PMID: 33857342Free PMC Article
Aspirin or heparin or both for improving pregnancy outcomes in women with persistent antiphospholipid antibodies and recurrent pregnancy loss.
Hamulyák EN, Scheres LJ, Marijnen MC, Goddijn M, Middeldorp S
Cochrane Database Syst Rev 2020 May 2;5(5):CD012852. doi: 10.1002/14651858.CD012852.pub2. PMID: 32358837Free PMC Article
Normal saline versus heparin for patency of central venous catheters in adult patients - a systematic review and meta-analysis.
Zhong L, Wang HL, Xu B, Yuan Y, Wang X, Zhang YY, Ji L, Pan ZM, Hu ZS
Crit Care 2017 Jan 8;21(1):5. doi: 10.1186/s13054-016-1585-x. PMID: 28063456Free PMC Article

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Reviews

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...