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Contagious pustular dermatitis

MedGen UID:
41702
•Concept ID:
C0013570
•
Disease or Syndrome
Synonyms: Contagious Ecthyma; Contagious Pustular Dermatitides; Contagious Pustular Dermatitis; Dermatitides, Contagious Pustular; Dermatitis, Contagious Pustular; Ecthyma, Contagious; Infection, Orf Virus; Infections, Orf Virus; Orf Virus Infection; Orf Virus Infections; Pustular Dermatitides, Contagious; Pustular Dermatitis, Contagious; Virus Infection, Orf; Virus Infections, Orf
SNOMED CT: Orf virus disease (74050005); Contagious pustular dermatitis (74050005); Orf (74050005); Contagious ovine ecthyma (74050005); Sore mouth (ovine) (74050005); Ecthyma contagiosum (74050005); Bovine pustular stomatitis (74050005); Contagious pustular stomatitis (74050005); Contagious ecthyma of sheep (74050005)
 
Monarch Initiative: MONDO:0005717

Definition

An infectious dermatitis of sheep and goats, affecting primarily the muzzle and lips. It is caused by a poxvirus and may be transmitted to humans. [from MONDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVContagious pustular dermatitis

Professional guidelines

PubMed

Use of a local anaesthetic and antiseptic wound formulation for the treatment of lambs naturally infected with Orf virus.
Gómez Á, Lacasta D, Teresa Tejedor M, Ruiz de Arcaute M, Ramos JJ, Ruiz H, Ortín A, Villanueva-Saz S, Reina R, Quílez P, Navarro T, Verde M, Borobia M, Windsor PA
Vet Microbiol 2024 May;292:110037. Epub 2024 Mar 3 doi: 10.1016/j.vetmic.2024.110037. PMID: 38479302
Orf Virus Infection in Humans: A Review With a Focus on Advances in Diagnosis and Treatment.
Caravaglio JV, Khachemoune A
J Drugs Dermatol 2017 Jul 1;16(7):684-689. PMID: 28697220
Orf in man--a treatment?
Morgan KL
Vet Rec 1987 May 30;120(22):539. doi: 10.1136/vr.120.22.539-a. PMID: 3672825

Recent clinical studies

Etiology

Human Orf: An Under-recognized Entity.
Santiago L, Oliveira D, Cardoso JC, Figueired A
Acta Dermatovenerol Croat 2019 Dec;27(4):280-281. PMID: 31969245
Comparative and retrospective molecular analysis of Parapoxvirus (PPV) isolates.
Friederichs S, Krebs S, Blum H, Wolf E, Lang H, von Buttlar H, Büttner M
Virus Res 2014 Mar 6;181:11-21. Epub 2013 Dec 27 doi: 10.1016/j.virusres.2013.12.015. PMID: 24373950
A case of orf (ecthyma contagiosum) with multiple lesions.
Turan E, Yesilova Y, Ucmak D
J Pak Med Assoc 2013 Jun;63(6):786-7. PMID: 23901689
Orf (contagious pustular dermatitis) in farmworkers: prevalence and risk factors in three areas of England.
Paiba GA, Thomas DR, Morgan KL, Bennett M, Salmon RL, Chalmers R, Kench SM, Coleman TJ, Meadows D, Morgan-Capner P, Softley P, Sillis M, Green LE
Vet Rec 1999 Jul 3;145(1):7-11. doi: 10.1136/vr.145.1.7. PMID: 10452390

Diagnosis

Human Orf: An Under-recognized Entity.
Santiago L, Oliveira D, Cardoso JC, Figueired A
Acta Dermatovenerol Croat 2019 Dec;27(4):280-281. PMID: 31969245
Extensive orf infection in a toddler with associated id reaction.
Haddock ES, Cheng CE, Bradley JS, Hsu CH, Zhao H, Davidson WB, Barrio VR
Pediatr Dermatol 2017 Nov;34(6):e337-e340. Epub 2017 Sep 21 doi: 10.1111/pde.13259. PMID: 28940500Free PMC Article
Orf (contagious pustular dermatitis) in farmworkers: prevalence and risk factors in three areas of England.
Paiba GA, Thomas DR, Morgan KL, Bennett M, Salmon RL, Chalmers R, Kench SM, Coleman TJ, Meadows D, Morgan-Capner P, Softley P, Sillis M, Green LE
Vet Rec 1999 Jul 3;145(1):7-11. doi: 10.1136/vr.145.1.7. PMID: 10452390
Orf: contagious pustular dermatitis.
Maki A Jr, Hinsberg A, Percheson P, Marshall DG
CMAJ 1988 Nov 15;139(10):971-2. PMID: 3179870Free PMC Article
Ocular infection with orf virus.
Freeman G, Bron AJ, Juel-Jensen B
Am J Ophthalmol 1984 May;97(5):601-4. doi: 10.1016/0002-9394(84)90380-5. PMID: 6539075

Therapy

Extensive orf infection in a toddler with associated id reaction.
Haddock ES, Cheng CE, Bradley JS, Hsu CH, Zhao H, Davidson WB, Barrio VR
Pediatr Dermatol 2017 Nov;34(6):e337-e340. Epub 2017 Sep 21 doi: 10.1111/pde.13259. PMID: 28940500Free PMC Article
Ocular infection with orf virus.
Freeman G, Bron AJ, Juel-Jensen B
Am J Ophthalmol 1984 May;97(5):601-4. doi: 10.1016/0002-9394(84)90380-5. PMID: 6539075

Prognosis

A case of orf (ecthyma contagiosum) with multiple lesions.
Turan E, Yesilova Y, Ucmak D
J Pak Med Assoc 2013 Jun;63(6):786-7. PMID: 23901689

Clinical prediction guides

Human Orf: An Under-recognized Entity.
Santiago L, Oliveira D, Cardoso JC, Figueired A
Acta Dermatovenerol Croat 2019 Dec;27(4):280-281. PMID: 31969245
Regulation of PACT-Mediated Protein Kinase Activation by the OV20.0 Protein of Orf Virus.
Tseng YY, Liao GR, Sen GC, Lin FY, Hsu WL
J Virol 2015 Nov;89(22):11619-29. Epub 2015 Sep 9 doi: 10.1128/JVI.01739-15. PMID: 26355092Free PMC Article
Suppression of influenza virus infection by the orf virus isolated in Taiwan.
Lin FY, Tseng YY, Chan KW, Kuo ST, Yang CH, Wang CY, Takasu M, Hsu WL, Wong ML
J Vet Med Sci 2015 Sep;77(9):1055-62. Epub 2015 Apr 7 doi: 10.1292/jvms.14-0663. PMID: 25855509Free PMC Article
Parapoxviruses: from the lesion to the viral genome.
Büttner M, Rziha HJ
J Vet Med B Infect Dis Vet Public Health 2002 Feb;49(1):7-16. doi: 10.1046/j.1439-0450.2002.00539.x. PMID: 11911596

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