U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from PMC

Resistance to hepatitis C virus(HCV)

MedGen UID:
332112
•Concept ID:
C1836031
•
Finding
Synonyms: HCV; HCV, RESISTANCE TO
 
OMIM®: 601373; 609532

Professional guidelines

PubMed

Primer on Hepatitis C Virus Resistance to Direct-Acting Antiviral Treatment: A Practical Approach for the Treating Physician.
Weisberg IS, Jacobson IM
Clin Liver Dis 2017 Nov;21(4):659-672. Epub 2017 Aug 19 doi: 10.1016/j.cld.2017.06.007. PMID: 28987254
Comprehensive Screening for Naturally Occurring Hepatitis C Virus Resistance to Direct-Acting Antivirals in the NS3, NS5A, and NS5B Genes in Worldwide Isolates of Viral Genotypes 1 to 6.
Patiño-Galindo JÁ, Salvatierra K, González-Candelas F, López-Labrador FX
Antimicrob Agents Chemother 2016 Apr;60(4):2402-16. Epub 2016 Mar 25 doi: 10.1128/AAC.02776-15. PMID: 26856832Free PMC Article
Naturally occurring substitutions conferring resistance to hepatitis C virus polymerase inhibitors in treatment-naive patients infected with genotypes 1-5.
Legrand-Abravanel F, Henquell C, Le Guillou-Guillemette H, Balan V, Mirand A, Dubois M, Lunel-Fabiani F, Payan C, Izopet J
Antivir Ther 2009;14(5):723-30. PMID: 19704176

Recent clinical studies

Etiology

Challenge Inoculum for Hepatitis C Virus Controlled Human Infection Model.
Liang TJ, Law JLM, Pietschmann T, Ray SC, Bukh J, Bull R, Chung RT, Tyrrell DL, Houghton M, Rice CM
Clin Infect Dis 2023 Aug 14;77(Suppl 3):S257-S261. doi: 10.1093/cid/ciad336. PMID: 37579208Free PMC Article
A Review on Extrahepatic Manifestations of Chronic Hepatitis C Virus Infection and the Impact of Direct-Acting Antiviral Therapy.
Mazzaro C, Quartuccio L, Adinolfi LE, Roccatello D, Pozzato G, Nevola R, Tonizzo M, Gitto S, Andreone P, Gattei V
Viruses 2021 Nov 9;13(11) doi: 10.3390/v13112249. PMID: 34835054Free PMC Article
Therapy Implications of Hepatitis C Virus Genetic Diversity.
Martinez MA, Franco S
Viruses 2020 Dec 29;13(1) doi: 10.3390/v13010041. PMID: 33383891Free PMC Article
New approaches in the treatment of hepatitis C.
González-Grande R, Jiménez-Pérez M, González Arjona C, Mostazo Torres J
World J Gastroenterol 2016 Jan 28;22(4):1421-32. doi: 10.3748/wjg.v22.i4.1421. PMID: 26819511Free PMC Article
Hepatitis C virus in the new era: perspectives in epidemiology, prevention, diagnostics and predictors of response to therapy.
Ansaldi F, Orsi A, Sticchi L, Bruzzone B, Icardi G
World J Gastroenterol 2014 Aug 7;20(29):9633-52. doi: 10.3748/wjg.v20.i29.9633. PMID: 25110404Free PMC Article

Diagnosis

Viral hepatitis update: Progress and perspectives.
Pisano MB, Giadans CG, Flichman DM, Ré VE, Preciado MV, Valva P
World J Gastroenterol 2021 Jul 14;27(26):4018-4044. doi: 10.3748/wjg.v27.i26.4018. PMID: 34326611Free PMC Article
Resistance to DAAs: When to Look and When It Matters.
Wyles DL
Curr HIV/AIDS Rep 2017 Dec;14(6):229-237. doi: 10.1007/s11904-017-0369-5. PMID: 29116550
New approaches in the treatment of hepatitis C.
González-Grande R, Jiménez-Pérez M, González Arjona C, Mostazo Torres J
World J Gastroenterol 2016 Jan 28;22(4):1421-32. doi: 10.3748/wjg.v22.i4.1421. PMID: 26819511Free PMC Article
Hepatitis C virus molecular evolution: transmission, disease progression and antiviral therapy.
Preciado MV, Valva P, Escobar-Gutierrez A, Rahal P, Ruiz-Tovar K, Yamasaki L, Vazquez-Chacon C, Martinez-Guarneros A, Carpio-Pedroza JC, Fonseca-Coronado S, Cruz-Rivera M
World J Gastroenterol 2014 Nov 21;20(43):15992-6013. doi: 10.3748/wjg.v20.i43.15992. PMID: 25473152Free PMC Article
Hepatitis C virus in the new era: perspectives in epidemiology, prevention, diagnostics and predictors of response to therapy.
Ansaldi F, Orsi A, Sticchi L, Bruzzone B, Icardi G
World J Gastroenterol 2014 Aug 7;20(29):9633-52. doi: 10.3748/wjg.v20.i29.9633. PMID: 25110404Free PMC Article

Therapy

Therapy Implications of Hepatitis C Virus Genetic Diversity.
Martinez MA, Franco S
Viruses 2020 Dec 29;13(1) doi: 10.3390/v13010041. PMID: 33383891Free PMC Article
Clinical Pharmacokinetics of Paritaprevir.
Menon RM, Polepally AR, Khatri A, Awni WM, Dutta S
Clin Pharmacokinet 2017 Oct;56(10):1125-1137. doi: 10.1007/s40262-017-0520-x. PMID: 28236252
New approaches in the treatment of hepatitis C.
González-Grande R, Jiménez-Pérez M, González Arjona C, Mostazo Torres J
World J Gastroenterol 2016 Jan 28;22(4):1421-32. doi: 10.3748/wjg.v22.i4.1421. PMID: 26819511Free PMC Article
Hepatitis C virus molecular evolution: transmission, disease progression and antiviral therapy.
Preciado MV, Valva P, Escobar-Gutierrez A, Rahal P, Ruiz-Tovar K, Yamasaki L, Vazquez-Chacon C, Martinez-Guarneros A, Carpio-Pedroza JC, Fonseca-Coronado S, Cruz-Rivera M
World J Gastroenterol 2014 Nov 21;20(43):15992-6013. doi: 10.3748/wjg.v20.i43.15992. PMID: 25473152Free PMC Article
Hepatitis C virus in the new era: perspectives in epidemiology, prevention, diagnostics and predictors of response to therapy.
Ansaldi F, Orsi A, Sticchi L, Bruzzone B, Icardi G
World J Gastroenterol 2014 Aug 7;20(29):9633-52. doi: 10.3748/wjg.v20.i29.9633. PMID: 25110404Free PMC Article

Prognosis

An Insight into Hepatitis C Virus: In Search of Promising Drug Targets.
Dwivedi M, Dwivedi A, Mukherjee D
Curr Drug Targets 2023;24(14):1127-1138. doi: 10.2174/0113894501265769231020031857. PMID: 37907492
A Review on Extrahepatic Manifestations of Chronic Hepatitis C Virus Infection and the Impact of Direct-Acting Antiviral Therapy.
Mazzaro C, Quartuccio L, Adinolfi LE, Roccatello D, Pozzato G, Nevola R, Tonizzo M, Gitto S, Andreone P, Gattei V
Viruses 2021 Nov 9;13(11) doi: 10.3390/v13112249. PMID: 34835054Free PMC Article
Hepatitis C and Its Metabolic Complications in Kidney Disease.
Fabrizi F, Donato FM, Messa P
Ann Hepatol 2017 November-December,;16(6):851-861. doi: 10.5604/01.3001.0010.5275. PMID: 29055921
Sofosbuvir and velpatasvir for the treatment of hepatitis C.
Jackson WE, Everson GT
Expert Rev Gastroenterol Hepatol 2017 Jun;11(6):501-505. Epub 2017 May 11 doi: 10.1080/17474124.2017.1326817. PMID: 28468532
Hepatitis C virus in the new era: perspectives in epidemiology, prevention, diagnostics and predictors of response to therapy.
Ansaldi F, Orsi A, Sticchi L, Bruzzone B, Icardi G
World J Gastroenterol 2014 Aug 7;20(29):9633-52. doi: 10.3748/wjg.v20.i29.9633. PMID: 25110404Free PMC Article

Clinical prediction guides

Resistance outside the substrate envelope: hepatitis C NS3/4A protease inhibitors.
Özen A, Prachanronarong K, Matthew AN, Soumana DI, Schiffer CA
Crit Rev Biochem Mol Biol 2019 Feb;54(1):11-26. Epub 2019 Mar 1 doi: 10.1080/10409238.2019.1568962. PMID: 30821513Free PMC Article
Hepatitis C and Its Metabolic Complications in Kidney Disease.
Fabrizi F, Donato FM, Messa P
Ann Hepatol 2017 November-December,;16(6):851-861. doi: 10.5604/01.3001.0010.5275. PMID: 29055921
Resistance Mechanisms in Hepatitis C Virus: implications for Direct-Acting Antiviral Use.
Bagaglio S, Uberti-Foppa C, Morsica G
Drugs 2017 Jul;77(10):1043-1055. doi: 10.1007/s40265-017-0753-x. PMID: 28497432
Resistance of Hepatitis C Virus to Inhibitors: Complexity and Clinical Implications.
Perales C, Quer J, Gregori J, Esteban JI, Domingo E
Viruses 2015 Nov 6;7(11):5746-66. doi: 10.3390/v7112902. PMID: 26561827Free PMC Article
Hepatitis C virus in the new era: perspectives in epidemiology, prevention, diagnostics and predictors of response to therapy.
Ansaldi F, Orsi A, Sticchi L, Bruzzone B, Icardi G
World J Gastroenterol 2014 Aug 7;20(29):9633-52. doi: 10.3748/wjg.v20.i29.9633. PMID: 25110404Free PMC Article

Recent systematic reviews

Treatment Outcomes of Sofosbuvir/Velpatasvir/Voxilaprevir in Direct-Acting Antiviral-Experienced Hepatitis C Virus Patients: A Systematic Review and Meta-Analysis.
Devan P, Tiong KLA, Neo JE, Mohan BP, Wijarnpreecha K, Tam YCS, Coppola N, Preda CM, Wong YJ
Viruses 2023 Jun 30;15(7) doi: 10.3390/v15071489. PMID: 37515176Free PMC Article
Hepatitis C in Tunisia from 1991 to 2019: A systematic review.
Khedhiri M, Triki H, Triki H
Tunis Med 2021 Feb;99(2):189-200. PMID: 33899186Free PMC Article
Systematic review: chronic viral hepatitis and metabolic derangement.
Wang CC, Cheng PN, Kao JH
Aliment Pharmacol Ther 2020 Jan;51(2):216-230. Epub 2019 Nov 20 doi: 10.1111/apt.15575. PMID: 31746482
Hepatitis C and Its Metabolic Complications in Kidney Disease.
Fabrizi F, Donato FM, Messa P
Ann Hepatol 2017 November-December,;16(6):851-861. doi: 10.5604/01.3001.0010.5275. PMID: 29055921
Hepatitis C in Children Co-infected With Human Immunodeficiency Virus.
Indolfi G, Bartolini E, Serranti D, Azzari C, Resti M
J Pediatr Gastroenterol Nutr 2015 Oct;61(4):393-9. doi: 10.1097/MPG.0000000000000895. PMID: 26147631

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Reviews

    Related information

    • ClinVar
      Related medical variations
    • OMIM
      Related records in OMIM
    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed
    • PubMed (OMIM)
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...