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Methylprednisolone response

MedGen UID:
981659
•Concept ID:
CN298575
•
Sign or Symptom
Drug:
methylprednisolone
MedGen UID:
7608
•Concept ID:
C0025815
•
Pharmacologic Substance
A synthetic corticosteroid with anti-inflammatory and immunomodulating properties. Methylprednisolone binds to and activates specific nuclear receptors, resulting in altered gene expression and inhibition of proinflammatory cytokine production. This agent also decreases the number of circulating lymphocytes, induces cell differentiation, and stimulates apoptosis in sensitive tumor cell populations. [from NCI]
methylprednisolone

Professional guidelines

PubMed

The 2021 European Group on Graves' orbitopathy (EUGOGO) clinical practice guidelines for the medical management of Graves' orbitopathy.
Bartalena L, Kahaly GJ, Baldeschi L, Dayan CM, Eckstein A, Marcocci C, Marinò M, Vaidya B, Wiersinga WM; EUGOGO †
Eur J Endocrinol 2021 Aug 27;185(4):G43-G67. doi: 10.1530/EJE-21-0479. PMID: 34297684
British Society of Gastroenterology consensus guidelines on the management of inflammatory bowel disease in adults.
Lamb CA, Kennedy NA, Raine T, Hendy PA, Smith PJ, Limdi JK, Hayee B, Lomer MCE, Parkes GC, Selinger C, Barrett KJ, Davies RJ, Bennett C, Gittens S, Dunlop MG, Faiz O, Fraser A, Garrick V, Johnston PD, Parkes M, Sanderson J, Terry H; IBD guidelines eDelphi consensus group, Gaya DR, Iqbal TH, Taylor SA, Smith M, Brookes M, Hansen R, Hawthorne AB
Gut 2019 Dec;68(Suppl 3):s1-s106. Epub 2019 Sep 27 doi: 10.1136/gutjnl-2019-318484. PMID: 31562236Free PMC Article
Management of Immune-Related Adverse Events in Patients Treated With Immune Checkpoint Inhibitor Therapy: American Society of Clinical Oncology Clinical Practice Guideline.
Brahmer JR, Lacchetti C, Schneider BJ, Atkins MB, Brassil KJ, Caterino JM, Chau I, Ernstoff MS, Gardner JM, Ginex P, Hallmeyer S, Holter Chakrabarty J, Leighl NB, Mammen JS, McDermott DF, Naing A, Nastoupil LJ, Phillips T, Porter LD, Puzanov I, Reichner CA, Santomasso BD, Seigel C, Spira A, Suarez-Almazor ME, Wang Y, Weber JS, Wolchok JD, Thompson JA; National Comprehensive Cancer Network
J Clin Oncol 2018 Jun 10;36(17):1714-1768. Epub 2018 Feb 14 doi: 10.1200/JCO.2017.77.6385. PMID: 29442540Free PMC Article

Curated

DailyMed Drug Label, methylprednisolone, 2012

Recent clinical studies

Etiology

Efficacy and safety of iguratimod combined with methylprednisolone for primary Sjögren's syndrome: a meta-analysis and trial sequential analysis.
Hu G, Yu YF, Yin S, Yang XY, Xu Q, You H
Eur Rev Med Pharmacol Sci 2023 Aug;27(16):7544-7556. doi: 10.26355/eurrev_202308_33406. PMID: 37667931
Effectiveness and safety profile of greater occipital nerve blockade in cluster headache: a systematic review.
Gordon A, Roe T, Villar-Martínez MD, Moreno-Ajona D, Goadsby PJ, Hoffmann J
J Neurol Neurosurg Psychiatry 2023 Dec 14;95(1):73-85. doi: 10.1136/jnnp-2023-331066. PMID: 36948579
Comparing efficacy and safety of tocilizumab and methylprednisolone in the treatment of patients with severe COVID-19.
Abbasian L, Toroghi N, Rahmani H, Khalili H, Hasannezhad M, Ghiasvand F, Jafari S, Salehi M, Salahshour F, Azadbakhsh Kanaf Gorabi M, Alizade F, Ghaderkhani S, Nakhostin M
Int Immunopharmacol 2022 Jun;107:108689. Epub 2022 Mar 17 doi: 10.1016/j.intimp.2022.108689. PMID: 35313272Free PMC Article
Racial/ethnic disparities on inflammation and response to methylprednisolone in severe COVID-19 pneumonia.
Go RC, Nyirenda T, Bojarian M, Hosseini DK, Kim K, Rahim M, Paleoudis EG, Go AC, Han Z, Sperber SJ, Gupta A
BMC Infect Dis 2022 Mar 14;22(1):254. doi: 10.1186/s12879-022-07237-1. PMID: 35287602Free PMC Article
Corticosteroids in airway management.
Hawkins DB, Crockett DM, Shum TK
Otolaryngol Head Neck Surg 1983 Dec;91(6):593-6. doi: 10.1177/019459988309100601. PMID: 6198612

Diagnosis

Effectiveness and safety profile of greater occipital nerve blockade in cluster headache: a systematic review.
Gordon A, Roe T, Villar-Martínez MD, Moreno-Ajona D, Goadsby PJ, Hoffmann J
J Neurol Neurosurg Psychiatry 2023 Dec 14;95(1):73-85. doi: 10.1136/jnnp-2023-331066. PMID: 36948579
Dysthyroid optic neuropathy: emerging treatment strategies.
Pelewicz-Sowa M, Miśkiewicz P
J Endocrinol Invest 2023 Jul;46(7):1305-1316. Epub 2023 Feb 18 doi: 10.1007/s40618-023-02036-0. PMID: 36802028Free PMC Article
Efficacy and safety of obinutuzumab in systemic lupus erythematosus patients with secondary non-response to rituximab.
Arnold J, Dass S, Twigg S, Jones CH, Rhodes B, Hewins P, Chakravorty M, Courtney P, Ehrenstein M, Md Yusof MY, Vital EM
Rheumatology (Oxford) 2022 Nov 28;61(12):4905-4909. doi: 10.1093/rheumatology/keac150. PMID: 35266512
Demyelinating steroid-responsive neurobrucellosis.
Ata F, Yousaf Z, Sharif MK, Abdallah A
BMJ Case Rep 2020 Mar 8;13(3) doi: 10.1136/bcr-2019-233798. PMID: 32152068Free PMC Article
Eosinophilic fasciitis.
Lamback EB, Resende FS, Lenzi TC
An Bras Dermatol 2016 Sep-Oct;91(5 suppl 1):57-59. doi: 10.1590/abd1806-4841.20164683. PMID: 28300895Free PMC Article

Therapy

Patient With Rigidity and Fasciculations: Steroid-Responsive Presentation of Anti-IgLON5 Disease.
Bellucci M, Castellano C, Marinelli L, Garbarino L, Gastaldi M, Franciotta D, Benedetti L
Neurology 2024 Feb 13;102(3):e208110. Epub 2024 Jan 11 doi: 10.1212/WNL.0000000000208110. PMID: 38207275
Treatments for chronic inflammatory demyelinating polyradiculoneuropathy (CIDP): an overview of systematic reviews.
Oaklander AL, Lunn MP, Hughes RA, van Schaik IN, Frost C, Chalk CH
Cochrane Database Syst Rev 2017 Jan 13;1(1):CD010369. doi: 10.1002/14651858.CD010369.pub2. PMID: 28084646Free PMC Article
Hypereosinophilic Syndrome: Hacettepe Experience.
Tavil B, Aytaç S, Unal S, Kuskonmaz B, Gumruk F, Cetin M
J Pediatr Hematol Oncol 2016 Oct;38(7):539-43. doi: 10.1097/MPH.0000000000000668. PMID: 27548336
Pulse steroid therapy.
Sinha A, Bagga A
Indian J Pediatr 2008 Oct;75(10):1057-66. Epub 2008 Nov 21 doi: 10.1007/s12098-008-0210-7. PMID: 19023530
Pulse methylprednisolone in SLE.
Kimberly RP
Clin Rheum Dis 1982 Apr;8(1):261-78. PMID: 6749399

Prognosis

Efficacy and safety of obinutuzumab in systemic lupus erythematosus patients with secondary non-response to rituximab.
Arnold J, Dass S, Twigg S, Jones CH, Rhodes B, Hewins P, Chakravorty M, Courtney P, Ehrenstein M, Md Yusof MY, Vital EM
Rheumatology (Oxford) 2022 Nov 28;61(12):4905-4909. doi: 10.1093/rheumatology/keac150. PMID: 35266512
Dexamethasone vs methylprednisolone high dose for Covid-19 pneumonia.
Pinzón MA, Ortiz S, Holguín H, Betancur JF, Cardona Arango D, Laniado H, Arias Arias C, Muñoz B, Quiceno J, Jaramillo D, Ramirez Z
PLoS One 2021;16(5):e0252057. Epub 2021 May 25 doi: 10.1371/journal.pone.0252057. PMID: 34033648Free PMC Article
Effect of corticosteroids on treatment failure among hospitalized patients with severe community-acquired pneumonia and high inflammatory response: a randomized clinical trial.
Torres A, Sibila O, Ferrer M, Polverino E, Menendez R, Mensa J, Gabarrús A, Sellarés J, Restrepo MI, Anzueto A, Niederman MS, Agustí C
JAMA 2015 Feb 17;313(7):677-86. doi: 10.1001/jama.2015.88. PMID: 25688779
Methylprednisolone infusion in early severe ARDS: results of a randomized controlled trial.
Meduri GU, Golden E, Freire AX, Taylor E, Zaman M, Carson SJ, Gibson M, Umberger R
Chest 2007 Apr;131(4):954-63. doi: 10.1378/chest.06-2100. PMID: 17426195
Pulse methylprednisolone in SLE.
Kimberly RP
Clin Rheum Dis 1982 Apr;8(1):261-78. PMID: 6749399

Clinical prediction guides

Efficacy and safety of iguratimod combined with methylprednisolone for primary Sjögren's syndrome: a meta-analysis and trial sequential analysis.
Hu G, Yu YF, Yin S, Yang XY, Xu Q, You H
Eur Rev Med Pharmacol Sci 2023 Aug;27(16):7544-7556. doi: 10.26355/eurrev_202308_33406. PMID: 37667931
Corticosteroids: A boon or bane for COVID-19 patients?
Sen S, Singh B, Biswas G
Steroids 2022 Dec;188:109102. Epub 2022 Aug 24 doi: 10.1016/j.steroids.2022.109102. PMID: 36029810Free PMC Article
Racial/ethnic disparities on inflammation and response to methylprednisolone in severe COVID-19 pneumonia.
Go RC, Nyirenda T, Bojarian M, Hosseini DK, Kim K, Rahim M, Paleoudis EG, Go AC, Han Z, Sperber SJ, Gupta A
BMC Infect Dis 2022 Mar 14;22(1):254. doi: 10.1186/s12879-022-07237-1. PMID: 35287602Free PMC Article
Efficacy and safety of obinutuzumab in systemic lupus erythematosus patients with secondary non-response to rituximab.
Arnold J, Dass S, Twigg S, Jones CH, Rhodes B, Hewins P, Chakravorty M, Courtney P, Ehrenstein M, Md Yusof MY, Vital EM
Rheumatology (Oxford) 2022 Nov 28;61(12):4905-4909. doi: 10.1093/rheumatology/keac150. PMID: 35266512
Pulse methylprednisolone in SLE.
Kimberly RP
Clin Rheum Dis 1982 Apr;8(1):261-78. PMID: 6749399

Recent systematic reviews

Effectiveness and safety profile of greater occipital nerve blockade in cluster headache: a systematic review.
Gordon A, Roe T, Villar-Martínez MD, Moreno-Ajona D, Goadsby PJ, Hoffmann J
J Neurol Neurosurg Psychiatry 2023 Dec 14;95(1):73-85. doi: 10.1136/jnnp-2023-331066. PMID: 36948579
Interventions for minimal change disease in adults with nephrotic syndrome.
Azukaitis K, Palmer SC, Strippoli GF, Hodson EM
Cochrane Database Syst Rev 2022 Mar 1;3(3):CD001537. doi: 10.1002/14651858.CD001537.pub5. PMID: 35230699Free PMC Article
Drugs for preventing postoperative nausea and vomiting in adults after general anaesthesia: a network meta-analysis.
Weibel S, Rücker G, Eberhart LH, Pace NL, Hartl HM, Jordan OL, Mayer D, Riemer M, Schaefer MS, Raj D, Backhaus I, Helf A, Schlesinger T, Kienbaum P, Kranke P
Cochrane Database Syst Rev 2020 Oct 19;10(10):CD012859. doi: 10.1002/14651858.CD012859.pub2. PMID: 33075160Free PMC Article
Guidelines for the diagnosis and management of critical illness-related corticosteroid insufficiency (CIRCI) in critically ill patients (Part I): Society of Critical Care Medicine (SCCM) and European Society of Intensive Care Medicine (ESICM) 2017.
Annane D, Pastores SM, Rochwerg B, Arlt W, Balk RA, Beishuizen A, Briegel J, Carcillo J, Christ-Crain M, Cooper MS, Marik PE, Umberto Meduri G, Olsen KM, Rodgers S, Russell JA, Van den Berghe G
Intensive Care Med 2017 Dec;43(12):1751-1763. Epub 2017 Sep 21 doi: 10.1007/s00134-017-4919-5. PMID: 28940011
Treatments for chronic inflammatory demyelinating polyradiculoneuropathy (CIDP): an overview of systematic reviews.
Oaklander AL, Lunn MP, Hughes RA, van Schaik IN, Frost C, Chalk CH
Cochrane Database Syst Rev 2017 Jan 13;1(1):CD010369. doi: 10.1002/14651858.CD010369.pub2. PMID: 28084646Free PMC Article

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