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Torsades de pointes

MedGen UID:
21214
Concept ID:
C0040479
Disease or Syndrome
Synonym: Torsade de pointes
SNOMED CT: Ventricular tachycardia, polymorphic with Q-T prolongation (31722008); Torsade de pointes (31722008); Torsades de pointes (31722008); Twisting spikes (31722008)
 
HPO: HP:0001664
Monarch Initiative: MONDO:0005478

Definition

A type of ventricular tachycardia characterized by polymorphioc QRS complexes that change in amplitue and cycle length, and thus have the appearance of oscillating around the baseline in the EKG. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • Torsades de pointes

Conditions with this feature

Professional guidelines

PubMed

Al-Khatib SM, Stevenson WG, Ackerman MJ, Bryant WJ, Callans DJ, Curtis AB, Deal BJ, Dickfeld T, Field ME, Fonarow GC, Gillis AM, Granger CB, Hammill SC, Hlatky MA, Joglar JA, Kay GN, Matlock DD, Myerburg RJ, Page RL
Heart Rhythm 2018 Oct;15(10):e190-e252. Epub 2017 Oct 30 doi: 10.1016/j.hrthm.2017.10.035. PMID: 29097320
Al-Khatib SM, Stevenson WG, Ackerman MJ, Bryant WJ, Callans DJ, Curtis AB, Deal BJ, Dickfeld T, Field ME, Fonarow GC, Gillis AM, Granger CB, Hammill SC, Hlatky MA, Joglar JA, Kay GN, Matlock DD, Myerburg RJ, Page RL
Circulation 2018 Sep 25;138(13):e210-e271. doi: 10.1161/CIR.0000000000000548. PMID: 29084733
Al-Khatib SM, Stevenson WG, Ackerman MJ, Bryant WJ, Callans DJ, Curtis AB, Deal BJ, Dickfeld T, Field ME, Fonarow GC, Gillis AM, Granger CB, Hammill SC, Hlatky MA, Joglar JA, Kay GN, Matlock DD, Myerburg RJ, Page RL
Circulation 2018 Sep 25;138(13):e272-e391. doi: 10.1161/CIR.0000000000000549. PMID: 29084731

Recent clinical studies

Etiology

Beach SR, Celano CM, Sugrue AM, Adams C, Ackerman MJ, Noseworthy PA, Huffman JC
Psychosomatics 2018 Mar-Apr;59(2):105-122. Epub 2017 Nov 3 doi: 10.1016/j.psym.2017.10.009. PMID: 29275963
Drug Ther Bull 2016 Mar;54(3):33-6. doi: 10.1136/dtb.2016.3.0390. PMID: 26966121
Thomas SH, Behr ER
Br J Clin Pharmacol 2016 Mar;81(3):420-7. Epub 2015 Oct 26 doi: 10.1111/bcp.12726. PMID: 26183037Free PMC Article
Heijman J, Voigt N, Carlsson LG, Dobrev D
Curr Opin Pharmacol 2014 Apr;15:16-21. Epub 2013 Nov 27 doi: 10.1016/j.coph.2013.11.004. PMID: 24721649
Beach SR, Celano CM, Noseworthy PA, Januzzi JL, Huffman JC
Psychosomatics 2013 Jan-Feb;54(1):1-13. doi: 10.1016/j.psym.2012.11.001. PMID: 23295003

Diagnosis

Chen Y, Fan Q, Liu Y, Shi Y, Luo H
Psychiatry Res 2023 Aug;326:115300. Epub 2023 Jun 22 doi: 10.1016/j.psychres.2023.115300. PMID: 37364503
Niimi N, Yuki K, Zaleski K
J Cardiothorac Vasc Anesth 2022 Jan;36(1):286-302. Epub 2020 Dec 13 doi: 10.1053/j.jvca.2020.12.011. PMID: 33495078
Adler A, Viskin S, Bhuiyan ZA, Eisenberg E, Rosso R
Heart Rhythm 2011 Dec;8(12):1952-4. Epub 2011 Jul 18 doi: 10.1016/j.hrthm.2011.07.015. PMID: 21763256
Jat KR, Lodha R, Kabra SK
Indian J Pediatr 2011 Feb;78(2):211-8. Epub 2010 Oct 27 doi: 10.1007/s12098-010-0276-x. PMID: 20978872
Agus ZS
J Am Soc Nephrol 1999 Jul;10(7):1616-22. doi: 10.1681/ASN.V1071616. PMID: 10405219

Therapy

Chen Y, Fan Q, Liu Y, Shi Y, Luo H
Psychiatry Res 2023 Aug;326:115300. Epub 2023 Jun 22 doi: 10.1016/j.psychres.2023.115300. PMID: 37364503
Chandrasekhar S, Fradley MG
Curr Treat Options Oncol 2019 May 25;20(7):55. doi: 10.1007/s11864-019-0657-y. PMID: 31129799
Med Lett Drugs Ther 2016 Dec 5;58(1509):153. PMID: 27906148
Thomas SH, Behr ER
Br J Clin Pharmacol 2016 Mar;81(3):420-7. Epub 2015 Oct 26 doi: 10.1111/bcp.12726. PMID: 26183037Free PMC Article
Adler A, Viskin S, Bhuiyan ZA, Eisenberg E, Rosso R
Heart Rhythm 2011 Dec;8(12):1952-4. Epub 2011 Jul 18 doi: 10.1016/j.hrthm.2011.07.015. PMID: 21763256

Prognosis

Strasburger JF, Eckstein G, Butler M, Noffke P, Wacker-Gussmann A
J Clin Pharmacol 2022 Sep;62 Suppl 1(Suppl 1):S53-S66. doi: 10.1002/jcph.2129. PMID: 36106782Free PMC Article
Li S, Xu Z, Guo M, Li M, Wen Z
Drug Discov Today 2022 Mar;27(3):831-837. Epub 2021 Oct 27 doi: 10.1016/j.drudis.2021.10.009. PMID: 34718206
Drug Ther Bull 2016 Mar;54(3):33-6. doi: 10.1136/dtb.2016.3.0390. PMID: 26966121
Bossu A, van der Heyden MA, de Boer TP, Vos MA
Expert Rev Cardiovasc Ther 2016;14(2):245-53. Epub 2015 Nov 26 doi: 10.1586/14779072.2016.1116940. PMID: 26560188
Kramer DB, Zimetbaum PJ
Cardiol Rev 2011 Sep-Oct;19(5):217-25. doi: 10.1097/CRD.0b013e3182203504. PMID: 21808164

Clinical prediction guides

Chen Y, Fan Q, Liu Y, Shi Y, Luo H
Psychiatry Res 2023 Aug;326:115300. Epub 2023 Jun 22 doi: 10.1016/j.psychres.2023.115300. PMID: 37364503
Strasburger JF, Eckstein G, Butler M, Noffke P, Wacker-Gussmann A
J Clin Pharmacol 2022 Sep;62 Suppl 1(Suppl 1):S53-S66. doi: 10.1002/jcph.2129. PMID: 36106782Free PMC Article
Lopez-Medina AI, Chahal CAA, Luzum JA
Pharmacogenomics 2022 Jun;23(9):543-557. Epub 2022 Jun 14 doi: 10.2217/pgs-2022-0027. PMID: 35698903Free PMC Article
Mason JW
J Antimicrob Chemother 2017 May 1;72(5):1272-1274. doi: 10.1093/jac/dkw591. PMID: 28160473
Bossu A, van der Heyden MA, de Boer TP, Vos MA
Expert Rev Cardiovasc Ther 2016;14(2):245-53. Epub 2015 Nov 26 doi: 10.1586/14779072.2016.1116940. PMID: 26560188

Recent systematic reviews

Chivers S, Ovadia C, Regan W, Zidere V, Vigneswaran T, Sharland G, Rosenthal E, Seed PT, Simpson JM, Williamson C
Heart Rhythm 2023 Apr;20(4):596-606. Epub 2022 Dec 22 doi: 10.1016/j.hrthm.2022.12.026. PMID: 36566891
Beach SR, Gross AF, Hartney KE, Taylor JB, Rundell JR
Gen Hosp Psychiatry 2020 Nov-Dec;67:42-50. Epub 2020 Aug 22 doi: 10.1016/j.genhosppsych.2020.08.008. PMID: 32979582
Gorelik E, Masarwa R, Perlman A, Rotshild V, Abbasi M, Muszkat M, Matok I
Drug Saf 2019 Apr;42(4):529-538. doi: 10.1007/s40264-018-0751-2. PMID: 30368737
Tampi RR, Balderas M, Carter KV, Tampi DJ, Moca M, Knudsen A, May J
Psychosomatics 2015 Jan-Feb;56(1):36-43. Epub 2014 Sep 6 doi: 10.1016/j.psym.2014.09.002. PMID: 25619672
Kaye P, O'Sullivan I
Emerg Med J 2002 Jul;19(4):288-91. doi: 10.1136/emj.19.4.288. PMID: 12101132Free PMC Article

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