Alarmins

A structurally diverse group of endogenous molecules that are multifunctional, having physiological functions inside the cell, but when released from dying cells or from cells under stress or certain immune cells, they function to activate INNATE IMMUNITY. Uncontrolled and excessive release of alarmins may contribute to INFLAMMATION; CARCINOGENESIS, and NEOPLASM METASTASIS. Alarmins are also critical for heart and nerve tissue homeostasis.

Year introduced: 2016

PubMed search builder options

Subheadings:

Restrict to MeSH Major Topic.

Do not include MeSH terms found below this term in the MeSH hierarchy.

Tree Number(s): D23.469.025

MeSH Unique ID: D000067531

Entry Terms:

• Alarmin Proteins
• Alarmin
• Danger-Associated Molecular Pattern Molecules
• Danger Associated Molecular Pattern Molecules
• Damage-Associated Molecular Pattern Molecules
• Damage Associated Molecular Pattern Molecules

Previous Indexing:

• HMGB1 Protein (2004-2015)

All MeSH Categories
Chemicals and Drugs Category
Biological Factors
Inflammation Mediators
Alarmins