MutL Proteins

DNA repair proteins that include the bacterial MutL protein and its eukaryotic homologs. They consist of a conserved N-terminal region with weak ATPase activity, an endonuclease motif, and a C-terminal domain that forms MutL homodimers or heterodimers between MLH1 and the PMS1, MISMATCH REPAIR ENDONUCLEASE PMS2; or MLH3 proteins. These complexes function in DNA repair pathways, primarily DNA MISMATCH REPAIR, where MutL/MLH1 and the MUTS DNA MISMATCH-BINDING PROTEIN are targeted to damaged DNA.

Year introduced: 2017

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Tree Number(s): D08.811.074.766, D08.811.277.040.025.215, D12.776.260.540

MeSH Unique ID: D000070956

Registry Number: EC 3.6.1.3

Entry Terms:

• MutL Homologs

Previous Indexing:

• Adenosine Triphosphatases (1992-2016)
• DNA Repair (1982-2016)

All MeSH Categories
Chemicals and Drugs Category
Enzymes and Coenzymes
Enzymes
DNA Repair Enzymes
MutL Proteins
Mismatch Repair Endonuclease PMS2
MutL Protein Homolog 1

All MeSH Categories
Chemicals and Drugs Category
Enzymes and Coenzymes
Enzymes
Hydrolases
Acid Anhydride Hydrolases
Adenosine Triphosphatases
MutL Proteins
Mismatch Repair Endonuclease PMS2
MutL Protein Homolog 1

All MeSH Categories
Chemicals and Drugs Category
Amino Acids, Peptides, and Proteins
Proteins
DNA-Binding Proteins
MutL Proteins
Mismatch Repair Endonuclease PMS2
MutL Protein Homolog 1