ADAMTS13 Protein
An ADAMTS protease that contains eight thrombospondin (TS) motifs. It cleaves VON WILLEBRAND FACTOR to control vWF-mediated THROMBOSIS. Mutations in the ADAMTS13 gene have been identified in familial cases of PURPURA, THROMBOTIC THROMBOCYTOPENIC and defects in ADAMTS13 activity are associated with MYOCARDIAL INFARCTION; BRAIN ISCHEMIA; PRE-ECLAMPSIA; and MALARIA.
Year introduced: 2017
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Subheadings:
Tree Number(s): D08.811.277.656.675.374.102.500.813, D09.400.430.500.500.813, D12.776.395.033.500.813, D12.776.860.300.085.813
MeSH Unique ID: D000071120
Registry Number: EC 3.4.24.87
Entry Terms:
- ADAMTS-13 Protein
- ADAMTS 13 Protein
- A Disintegrin and Metalloproteinase with Thrombospondin Motifs 13 Protein
- ADAMTS13 Protease
- vWF-Cleaving Protease
- vWF Cleaving Protease
- von Willebrand Factor-Cleaving Protease
- von Willebrand Factor Cleaving Protease
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