Leucine-Rich Repeat Serine-Threonine Protein Kinase-2

A serine/threonine protein kinase with GTPase activity that contains 12 LEUCINE-rich repeats in its central region and 7 WD repeats C-terminal to its kinase and GTPase domains. It localizes to TRANSPORT VESICLES; the OUTER MITOCHONDRIAL MEMBRANE; and the GOLGI APPARATUS. It functions in PROTEIN TRANSPORT; regulates neuron morphology in the central nervous system, and also functions in the trafficking of SYNAPTIC VESICLES. Mutations in the LRRK2 gene have been identified in autosomal dominant cases of PARKINSON DISEASE (PARK8).

Year introduced: 2017

PubMed search builder options

Subheadings:

Restrict to MeSH Major Topic.

Do not include MeSH terms found below this term in the MeSH hierarchy.

Tree Number(s): D08.811.913.696.620.682.700.534, D12.776.476.563.534, D12.776.705.750

MeSH Unique ID: D000071158

Registry Number: EC 2.7.11.1

Entry Terms:

• Leucine Rich Repeat Serine Threonine Protein Kinase 2
• LRRK2 Protein
• PARK8 Protein
• Dardarin Protein

Previous Indexing:

• Protein-Serine-Threonine Kinases (2005-2016)

All MeSH Categories
Chemicals and Drugs Category
Enzymes and Coenzymes
Enzymes
Transferases
Phosphotransferases
Phosphotransferases (Alcohol Group Acceptor)
Protein Kinases
Protein Serine-Threonine Kinases
Leucine-Rich Repeat Serine-Threonine Protein Kinase-2

All MeSH Categories
Chemicals and Drugs Category
Amino Acids, Peptides, and Proteins
Proteins
Intracellular Signaling Peptides and Proteins
Protein Serine-Threonine Kinases
Leucine-Rich Repeat Serine-Threonine Protein Kinase-2

All MeSH Categories
Chemicals and Drugs Category
Amino Acids, Peptides, and Proteins
Proteins
Parkinson Disease Associated Proteins
Leucine-Rich Repeat Serine-Threonine Protein Kinase-2