Beclin-1
An autophagy related protein which functions as a core subunit of PHOSPHATIDYLINOSITOL 3-KINASE MULTIPROTEIN COMPLEXES. It mediates the formation of phosphatidylinositol 3-phosphate and functions in AUTOPHAGY, where it is required for maturation of the AUTOPHAGOSOME. It also functions in ENDOCYTOSIS and CYTOKINESIS as part of a separate complex. Beclin-1 associates with INTRACELLULAR MEMBRANES and interacts with the PROTO-ONCOGENE PROTEINS C-BCL-2 and BCL-X PROTEIN.
Year introduced: 2017
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Subheadings:
Tree Number(s): D12.644.360.075.335, D12.776.094.500, D12.776.476.075.335
MeSH Unique ID: D000071186
Entry Terms:
- Beclin 1
- Beclin-1 Protein
- Beclin 1 Protein
- ATG6 Protein
- ATG-6 Protein
- ATG 6 Protein
- Coiled-coil Myosin-like Bcl2-interacting Protein
- Coiled coil Myosin like Bcl2 interacting Protein
- GT197 Protein
- Beclin1
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