Enhancer of Zeste Homolog 2 Protein
A histone-lysine N-methyltransferase and catalytic subunit of Polycomb Repressive Complex 2. It methylates LYSINE 9 (H3K9me) and LYSINE 27 (H3K27me) of HISTONE H3, leading to transcriptional repression of the affected target gene. EZH2 also methylates non-histone proteins such as GATA4 TRANSCRIPTION FACTOR and the nuclear receptor RORA. It regulates CIRCADIAN CLOCKS via histone methylation of circadian protein gene PROMOTER REGIONS, and its repressive activity is also important for the identity and differentiation of EMBRYONIC STEM CELLS.
Year introduced: 2017 (2005)
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Subheadings:
Tree Number(s): D05.500.781.750.250, D08.811.913.555.500.800.200.500.500.500, D12.776.660.235.600.200.250, D12.776.664.235.800.200.250, D12.776.930.780.890.200.250
MeSH Unique ID: D000071221
Registry Number: EC 2.1.1.43
Entry Terms:
- Enhancer of Zeste Homolog 2
- Lysine N-Methyltransferase-6
- Lysine N Methyltransferase 6
- Histone-Lysine N-Methyltransferase EZH2
- EZH2, Histone-Lysine N-Methyltransferase
- Histone Lysine N Methyltransferase EZH2