Carbonic Anhydrase IX
A carbonic anhydrase and transmembrane protein that consists of an N-terminal PROTEOGLYCAN-like domain, a catalytic region, a single-pass transmembrane domain, and a short intracellular tail. It functions as a dimer and is expressed primarily by cells of the GASTROINTESTINAL TRACT; BILE DUCT EPITHELIUM; and GALL BLADDER. It is expressed at high levels in many solid tumors, especially CLEAR CELL RENAL CARCINOMA, in response to CELL HYPOXIA.
Year introduced: 2017
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Subheadings:
Tree Number(s): D08.811.520.241.300.150.450, D12.776.543.178, D23.050.285.196
MeSH Unique ID: D000071231
Registry Number: EC 4.2.1.1
Entry Terms:
- Carbonic Anhydrase 9
- CAIX Protein
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