Lumican

A small leucine-rich proteoglycan that contains 10 tandem leucine repeats and four N-linked sites within the leucine repeat region that may be substituted with KERATAN SULFATE. These properties and its horseshoe shape allow it to mediate interactions among COLLAGEN molecules within fibrils. It is expressed in most mesenchymal tissues as well as the CORNEA, where it functions to maintain transparency.

Year introduced: 2017 (1978)

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Tree Number(s): D09.400.430.930.875.750, D09.698.735.700.875, D12.776.395.650.875.750, D12.776.860.300.806.875

MeSH Unique ID: D000071234

Entry Terms:

• Lumican Proteoglycan

All MeSH Categories
Chemicals and Drugs Category
Carbohydrates
Glycoconjugates
Glycoproteins
Proteoglycans
Small Leucine-Rich Proteoglycans
Lumican

All MeSH Categories
Chemicals and Drugs Category
Carbohydrates
Polysaccharides
Proteoglycans
Small Leucine-Rich Proteoglycans
Lumican

All MeSH Categories
Chemicals and Drugs Category
Amino Acids, Peptides, and Proteins
Proteins
Glycoproteins
Proteoglycans
Small Leucine-Rich Proteoglycans
Lumican

All MeSH Categories
Chemicals and Drugs Category
Amino Acids, Peptides, and Proteins
Proteins
Scleroproteins
Extracellular Matrix Proteins
Small Leucine-Rich Proteoglycans
Lumican