Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha
A transcriptional co-activator for NUCLEAR RECEPTORS. It is characterized by an N-terminal LxxLL sequence, a region that interacts with PPAR GAMMA, and a C-terminal RNA RECOGNITION MOTIF. It increases expression of MITOCHONDRIAL UNCOUPLING PROTEIN to regulate genes involved in metabolic reprogramming in response to dietary restriction and the integration of CIRCADIAN RHYTHMS with ENERGY METABOLISM.
Year introduced: 2017
PubMed search builder options
Subheadings:
Tree Number(s): D12.644.360.024.314.650, D12.776.157.057.080.650, D12.776.157.725.813.875, D12.776.476.024.394.650, D12.776.660.675.650, D12.776.664.962.813.875, D12.776.930.617.650
MeSH Unique ID: D000071248
Entry Terms:
- Peroxisome Proliferator Activated Receptor Gamma Coactivator 1 alpha
- PPARGC-1-alpha Protein
- PPARGC 1 alpha Protein
- PGC-1-alpha Protein
- PGC 1 alpha Protein
- PPARGC1a Protein
Previous Indexing: