Sequestosome-1 Protein
A multidomain protein that is highly conserved among multicellular organisms. It contains a ZZ-type ZINC FINGER domain, C-terminal UBIQUITIN - associated (UBA) domain, and interacts with many other signaling proteins and enzymes including, atypical PROTEIN KINASE C; TNF RECEPTOR-ASSOCIATED FACTOR 6; subunits of the mTORC1 complex, and CASPASE-8. It functions in AUTOPHAGY as a receptor for the degradation of ubiquitinated substrates, and to co-ordinate signaling in response to OXIDATIVE STRESS.
Year introduced: 2017
PubMed search builder options
Subheadings:
Tree Number(s): D12.644.360.024.329, D12.776.094.750, D12.776.157.057.160, D12.776.476.024.422
MeSH Unique ID: D000071456
Entry Terms:
- Sequestosome 1 Protein
- EBI3-Associated Protein of 60 KDa
- EBI3 Associated Protein of 60 KDa
- EBIAP Protein
- Phosphotyrosine-Independent Ligand For The Lck SH2 Domain Of 62 Kda
- Phosphotyrosine Independent Ligand For The Lck SH2 Domain Of 62 Kda
- Ubiquitin-Binding Protein p62
- Ubiquitin Binding Protein p62
Previous Indexing: