AlkB Homolog 4, Lysine Demethylase

A dioxygenase and alkylation repair homolog that mediates demethylation of ACTIN monomethylated at 'Lys-84' (K84me1). Demethylation of actin LYSINE 84 (K84me1) is required for maintaining actin and MYOSIN dynamics to support normal cleavage furrow ingression during CYTOKINESIS and CELL MIGRATION. It may also be involved in transcription regulation.

Year introduced: 2017

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Tree Number(s): D08.811.682.662.582.138, D08.811.682.690.416.139.937

MeSH Unique ID: D000071501

Registry Number: EC 1.14.11.27

Entry Terms:

• Alpha-Ketoglutarate-Dependent Dioxygenase Alkb Homolog 4
• Alpha Ketoglutarate Dependent Dioxygenase Alkb Homolog 4
• Alkylated DNA Repair Protein AlkB Homolog 4

Previous Indexing:

• Dioxygenases (2014-2016)

All MeSH Categories
Chemicals and Drugs Category
Enzymes and Coenzymes
Enzymes
Oxidoreductases
Oxidoreductases Acting on CH-NH Group Donors
Oxidoreductases, N-Demethylating
AlkB Homolog 4, Lysine Demethylase

All MeSH Categories
Chemicals and Drugs Category
Enzymes and Coenzymes
Enzymes
Oxidoreductases
Oxygenases
Dioxygenases
AlkB Enzymes
AlkB Homolog 4, Lysine Demethylase