Protein Phosphatase 2C
One of four major classes of mammalian serine/threonine specific protein phosphatases. Protein phosphatase 2C is a monomeric enzyme about 42 kDa in size. It shows broad substrate specificity dependent on divalent cations (mainly manganese and magnesium). Three isozymes are known in mammals: PP2C -alpha, -beta and -gamma. In yeast, there are four PP2C homologues: phosphatase PTC1 that have weak tyrosine phosphatase activity, phosphatase PTC2, phosphatase PTC3, and PTC4. Isozymes of PP2C also occur in Arabidopsis thaliana where the kinase-associated protein phosphatase (KAPP) containing a C-terminal PP2C domain, dephosphorylates Ser/Thr receptor-like kinase RLK5.
Year introduced: 2017 (2016)
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Subheadings:
Tree Number(s): D08.811.277.352.650.625.716, D12.776.476.559.716
MeSH Unique ID: D000071636
Registry Number: EC 3.1.3.16
Entry Terms:
- 2C, Protein Phosphatase
- Phosphatase 2C, Protein
- PPM1 Protein Phosphatases
- Phosphatases, PPM1 Protein
- Protein Phosphatases, PPM1
- Ptc2 Phosphatase
- Phosphatase, Ptc2
- PPM1 Magnesium-Dependent Protein Phosphatases
- PPM1 Magnesium Dependent Protein Phosphatases
- Protein Phosphatase 2C beta
- PP2C beta
- beta, PP2C
- Ppm1b Phosphatase
- Phosphatase, Ppm1b
- Protein Phosphatase 2C gamma
- PPM1G Phosphatase
- Phosphatase, PPM1G
- PP2Cgamma
- Magnesium-Dependent Protein Phosphatase 2C beta
- Magnesium Dependent Protein Phosphatase 2C beta
- Protein Phosphatase 2C epsilon
- PPM1E Phosphatase
- Phosphatase, PPM1E
- PP2Cepsilon
- Protein Phosphatase 2C delta
- Protein Phosphatase 1D Magnesium-Dependent, delta isoform
- Protein Phosphatase 1D Magnesium Dependent, delta isoform
- PPM1D Phosphatase
- Phosphatase, PPM1D