Zinc Finger E-box-Binding Homeobox 1
A transcription factor characterized by N-terminal and C-terminal CYS2-HIS2 ZINC FINGERS separated by a homeobox. It represses the expression of E-CADHERIN to induce the EPITHELIAL-MESENCHYMAL TRANSITION. It also represses PROTO-ONCOGENE PROTEINS C-BCL-6; regulates the cell type-specific expression of SODIUM-POTASSIUM-EXCHANGING ATPASE; and promotes neuronal differentiation.
Year introduced: 2017
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Subheadings:
Tree Number(s): D12.776.260.400.906, D12.776.260.703.800, D12.776.930.780.945
MeSH Unique ID: D000071799
Entry Terms:
- Zinc Finger E box Binding Homeobox 1
- Zeb1 Transcription Factor
- Transcription Factor, Zeb1
- NIL-2-A Zinc Finger Protein
- NIL 2 A Zinc Finger Protein
- Transcription Factor 8
- TCF8 Protein
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