Kelch-Like ECH-Associated Protein 1

An adaptor protein characterized by an N-terminal BTB-POZ DOMAIN and six KELCH REPEATS that functions as a substrate for the E3 UBIQUITIN LIGASE complex. It negatively-regulates NF-E2-RELATED FACTOR 2 by targeting it for ubiquitination and degradation by the PROTEASOME. It also represses genes regulated by ANTIOXIDANT RESPONSE ELEMENTS.

Year introduced: 2017

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Tree Number(s): D12.644.360.024.306, D12.776.157.057.067, D12.776.476.024.387

MeSH Unique ID: D000072019

Entry Terms:

• Kelch Like ECH Associated Protein 1
• KEAP1 Protein
• KEAP-1 Protein
• KEAP 1 Protein

Previous Indexing:

• Adaptor Proteins, Signal Transducing (2005-2016)
• Carrier Proteins (1999-2016)
• Intracellular Signaling Peptides and Proteins (2004-2016)

All MeSH Categories
Chemicals and Drugs Category
Amino Acids, Peptides, and Proteins
Peptides
Intracellular Signaling Peptides and Proteins
Adaptor Proteins, Signal Transducing
Kelch-Like ECH-Associated Protein 1

All MeSH Categories
Chemicals and Drugs Category
Amino Acids, Peptides, and Proteins
Proteins
Carrier Proteins
Adaptor Proteins, Signal Transducing
Kelch-Like ECH-Associated Protein 1

All MeSH Categories
Chemicals and Drugs Category
Amino Acids, Peptides, and Proteins
Proteins
Intracellular Signaling Peptides and Proteins
Adaptor Proteins, Signal Transducing
Kelch-Like ECH-Associated Protein 1