Phosphatidylinositol-3,4,5-Trisphosphate 5-Phosphatases
Phosphoinositide phosphatases that catalyze the dephosphorylation (hydrolysis) of phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P(3)) to produce PtdIns(3,4)P(2), which negatively regulates the PI3K ( 3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASES) pathways. They contain an SH2 DOMAIN and STERILE ALPHA MOTIF and have important functions in regulating the immune response and other cellular processes in vertebrates.
Year introduced: 2017
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Subheadings:
Tree Number(s): D08.811.277.352.650.624.750
MeSH Unique ID: D000072183
Registry Number: EC 3.1.3.86
Entry Terms:
- SHIP Phosphatases
- Phosphatases, SHIP
- Src Homology 2 Domain-Containing Inositol Phosphatases
- Src Homology 2 Domain Containing Inositol Phosphatases
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