Dishevelled Proteins
A family of proteins that are key components of the WNT SIGNALING PATHWAY, where they function downstream of FRIZZLED RECEPTORS. They contain an N-terminal dishevelled-AXIN PROTEIN (DIX) domain, which mediates oligomerization; a central PDZ DOMAIN which binds to the frizzled receptor; and a C-terminal DEP domain which facilitates binding to the CELL MEMBRANE. Dishevelled proteins have important functions in CELL DIFFERENTIATION and establishing CELL POLARITY.
Year introduced: 2017 (1994)
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Subheadings:
Tree Number(s): D12.644.360.024.288, D12.776.157.057.028, D12.776.476.024.330
MeSH Unique ID: D000072261
Entry Terms:
- Dishevelled Protein
- Dishevelled-1 Protein
- Dishevelled 1 Protein
- Dishevelled-2 Protein
- Dishevelled 2 Protein
- Dishevelled-3 Protein
- Dishevelled 3 Protein