Copper-Transporting ATPases
P-type ATPases which transport copper ions across membranes in prokaryotic and eukaryotic cells. They possess a conserved CYSTEINE-HISTIDINE-SERINE (CPx) amino acid motif within their transmembrane helices that functions in cation translocation and catalytic activation, and an N-terminal copper-binding CxxC motif that regulates enzyme activity. They play essential roles in intracellular copper homeostasis through regulating the uptake, efflux and storage of copper ions, and in cuproprotein biosynthesis.
Year introduced: 2018 (1994)
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Subheadings:
Tree Number(s): D08.811.277.040.025.314.500, D12.776.157.530.450.250.578.750, D12.776.157.530.813.500, D12.776.543.585.450.250.578.750, D12.776.543.585.813.500
MeSH Unique ID: D000073840
Registry Number: EC 7.2.2.8
Entry Terms:
- ATPases, Copper-Transporting
- Copper Transporting ATPases
- Copper-Transporting ATPase
- ATPase, Copper-Transporting
- Copper Transporting ATPase
- Copper-Transporting Adenosine Triphosphatases
- Adenosine Triphosphatases, Copper-Transporting
- Copper Transporting Adenosine Triphosphatases
- Triphosphatases, Copper-Transporting Adenosine
- Cu(+)-Transporting ATPases
- Cu-Transporting ATPases
- ATPases, Cu-Transporting
- Cu Transporting ATPases
- Pineal Night-Specific ATPase
- ATPase, Pineal Night-Specific
- Night-Specific ATPase, Pineal
- Pineal Night Specific ATPase
- PINA Enzyme
- Wilson Disease Protein
- Copper-Transporting ATPase 2
- ATPase 2, Copper-Transporting
- Copper Transporting ATPase 2
- ATP7B Cu-Binding P Type ATPase
- ATP7B Cu Binding P Type ATPase
- Wilson Disease Cu-Binding P Type ATPase
- Wilson Disease Cu Binding P Type ATPase
- ATPase, Cu++ Transporting, beta Polypeptide (Wilson Disease)
- Copper-Transporting ATPase 1
- ATPase 1, Copper-Transporting
- Copper Transporting ATPase 1
- ATPase Copper Transporting alpha
- Copper Pump 1
- ATP7A Protein
- Menkes Disease-Associated Protein
- Menkes Disease Associated Protein
See Also: