Triggering Receptor Expressed on Myeloid Cells-1
An approximately 230 amino acid membrane glycoprotein characterized by an IMMUNOGLOBULIN V-SET DOMAIN in its N-terminal half. It is expressed by MONOCYTES and NEUTROPHILS in response to INFLAMMATION related to bacterial and fungal infections. It triggers the release of pro-inflammatory CHEMOKINES; CYTOKINES, and expression of cell activation markers and is a critical regulator of SEPTIC SHOCK.
Year introduced: 2018
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Subheadings:
Tree Number(s): D09.400.430.890.919, D12.776.395.550.919, D12.776.543.550.919, D12.776.543.750.705.985
MeSH Unique ID: D000073871
Entry Terms:
- Triggering Receptor Expressed on Myeloid Cells 1
- CD354 Antigen
- Antigen, CD354
- TREM-1 Protein
- TREM 1 Protein
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