Protein Kinase C-theta

A calcium-independent, phospholipid- and diacylglycerol-dependent, protein kinase C subtype that contains an N-terminal C2 DOMAIN and two diacylglycerol-binding ZINC FINGERS. It is expressed primarily by T-LYMPHOCYTES and localizes to IMMUNOLOGICAL SYNAPSES where it regulates downstream signaling for the activation, proliferation, and survival of mature T-cells. It plays a critical role in allergic, autoimmune, and alloimmune responses of TH2 CELLS and TH17 CELLS.

Year introduced: 2018

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Tree Number(s): D08.811.913.696.620.682.700.725.075, D12.776.476.563.725.075

MeSH Unique ID: D000074121

Registry Number: EC 2.7.11.13

Entry Terms:

• Protein Kinase C theta
• Protein Kinase C, theta
• PKC-theta
• PKC theta
• PRKCQ

Previous Indexing:

• Isoenzymes (1992-2017)
• Protein Kinase C (1992-2017)

All MeSH Categories
Chemicals and Drugs Category
Enzymes and Coenzymes
Enzymes
Transferases
Phosphotransferases
Phosphotransferases (Alcohol Group Acceptor)
Protein Kinases
Protein Serine-Threonine Kinases
Protein Kinase C
Protein Kinase C-theta

All MeSH Categories
Chemicals and Drugs Category
Amino Acids, Peptides, and Proteins
Proteins
Intracellular Signaling Peptides and Proteins
Protein Serine-Threonine Kinases
Protein Kinase C
Protein Kinase C-theta