Serine Peptidase Inhibitor Kazal-Type 5

A secreted serine peptidase inhibitor that consists of 15 KAZAL MOTIFS and inhibits KALLIKREINS KLK5, KLK7, and KLK14 as well as TRYPSIN. It plays important roles in protecting MUCOSA against infection and inflammation, and in maintaining the integrity of the skin. Mutations in the SPINK5 gene are associated with NETHERTON SYNDROME.

Year introduced: 2018

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Tree Number(s): D12.644.822.750.250, D12.776.815.688.250

MeSH Unique ID: D000074163

Entry Terms:

• Serine Peptidase Inhibitor Kazal Type 5
• Serine Protease Inhibitor Kazal-Type 5
• Serine Protease Inhibitor Kazal Type 5
• Lympho-Epithelial Kazal-Type Inhibitor
• Inhibitor, Lympho-Epithelial Kazal-Type
• Kazal-Type Inhibitor, Lympho-Epithelial
• Lympho Epithelial Kazal Type Inhibitor
• SPINK5 Protein
• LEKTI Protein

Previous Indexing:

• Carrier Proteins (1999-2017)
• Proteinase Inhibitory Proteins, Secretory (2005-2017)

See Also:

• Netherton Syndrome
• Kazal Motifs

All MeSH Categories
Chemicals and Drugs Category
Amino Acids, Peptides, and Proteins
Peptides
Proteinase Inhibitory Proteins, Secretory
Serine Peptidase Inhibitors, Kazal Type
Serine Peptidase Inhibitor Kazal-Type 5

All MeSH Categories
Chemicals and Drugs Category
Amino Acids, Peptides, and Proteins
Proteins
Proteinase Inhibitory Proteins, Secretory
Serine Peptidase Inhibitors, Kazal Type
Serine Peptidase Inhibitor Kazal-Type 5