NADPH Oxidase 2
An NADPH oxidase that is expressed by PHAGOCYTES where it transfers electrons across the plasma membrane from cytosolic NADPH to molecular oxygen on the exterior. It regulates proton (H+) flux into resting phagocytes to control intracellular pH. Mutations in the CYBB gene are associated with X-LINKED CHRONIC GRANULOMATOUS DISEASE.
Year introduced: 2018
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Subheadings:
Tree Number(s): D08.811.682.608.575.875, D12.776.331.894.875, D12.776.543.653.875
MeSH Unique ID: D000074662
Registry Number: EC 1.6.3.-
Entry Terms:
- Oxidase 2, NADPH
- Cytochrome B-245 Beta Chain
- Cytochrome B 245 Beta Chain
- NOX2 Protein
- GP91-PHOX Protein
- GP91 PHOX Protein
- CYBB Protein
- Chronic Granulomatous Disease Protein
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